wdr45
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  • Official Full Name
  • WD repeat domain 45
  • Background
  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined.
  • Synonyms
  • WDR45; WD repeat domain 45; WD repeat domain, X linked 1 , WDRX1; WD repeat domain phosphoinositide-interacting protein 4; JM5; WIPI4; WD repeat containing protein 45; WD repeat domain phosphoinositide interacting protein 4; WD repeat domain, X linked 1; WD45 repeat protein interacting with phosphoinositides 4; WDRX1; WDRXI4; WIPI 4; WD repeat domain, X-linked 1; WD repeat-containing protein 45; WIPI-4
Cat.#:WDR45-3715HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WDR45, GST-tagged
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Cat.#:WDR45-18475MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse WDR45 Protein
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Cat.#:WDR45-6568RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat WDR45 Protein
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Cat.#:WDR45-5200RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey WDR45 Protein, His-tagged
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Cat.#:WDR45-10571ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish WDR45
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Cat.#:WDR45-346HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human WDR45 293 Cell Lysate
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Involved Pathway

WDR45 involved in several pathways and played different roles in them. We selected most pathways WDR45 participated on our site, such as Cellular responses to stress, Macroautophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with WDR45 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cellular responses to stress
EEF1A1; MAPKAPK2B; BMI1B; AMBRA1; SCMH1; HSBP1B; POT1; HIF1AL; CEBPB; CDKN2D
Macroautophagy
WDR45; AMBRA1B; ATG7; ULK1A; GABARAP; GABARAPL2; AMBRA1; WIPI2; ATG9B; WIPI1

Protein Function

WDR45 has several biochemical functions, for example, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-3-phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WDR45 itself. We selected most functions WDR45 had, and list some proteins which have the same functions with WDR45. You can find most of the proteins on our site.
Function
Related Protein
Function phosphatidylinositol-3,5-bisphosphate binding
Related Protein MAPKAP1; SNX14; WDR45; FAM21C; CLVS1; WDR45L; D6WSU116E; WIPI2; COMMD1; RAG2
Function phosphatidylinositol-3-phosphate binding
Related Protein WDR45B; WDR45; SH3PXD2B; JPH2; ZFYVE19; ZFYVE28; FAM21C; VPS36; BBS5; SNX13

Interacting Protein

WDR45 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WDR45 here. Most of them are supplied by our site. Hope this information will be useful for your research of WDR45.
MDM2; ATG2A; ATG2B; mgtE; ATG2A; Atg2a

WDR45 Related Articles

Saitsu, H; Nishimura, T; et al. De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood. NATURE GENETICS 45:445-449(2013).
Guderian, G; Peter, C; et al. RioK1, a New Interactor of Protein Arginine Methyltransferase 5 (PRMT5), Competes with pICln for Binding and Modulates PRMT5 Complex Composition and Substrate Specificity. JOURNAL OF BIOLOGICAL CHEMISTRY 286:1976-1986(2011).