• Official Full Name
  • zona pellucida glycoprotein 4
  • Background
  • The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4.
  • Synonyms
  • ZP4; zona pellucida glycoprotein 4; zona pellucida sperm-binding protein 4; ZPB; zona pellucida B protein; zona pellucida protein B; ZBP; ZP1; Zp-4
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ZP4 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ZP4

ZP4 Related Articles

Petit, FM; Serres, C; et al. Moonlighting proteins in sperm-egg interactions. BIOCHEMICAL SOCIETY TRANSACTIONS 42:1740-1743(2014).
Avella, MA; Baibakov, B; et al. A single domain of the ZP2 zona pellucida protein mediates gamete recognition in mice and humans. JOURNAL OF CELL BIOLOGY 205:801-809(2014).