acoc
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Bacillus subtilis | ACOC-1822B | Recombinant Bacillus subtilis ACOC protein, His-tagged | E. coli or Yeast | His |
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Ask a questionThere is limited information available about the effects of ACOC deficiency in humans, but studies in mice suggest that it may cause alterations in lipid metabolism, oxidative stress, and inflammation. It may also contribute to the development of insulin resistance.
NAFLD is characterized by the accumulation of fat in the liver, which can lead to inflammation, fibrosis, and hepatocellular carcinoma. ACOC has been shown to play a role in the regulation of lipid metabolism in the liver, and its deficiency has been associated with the development of NAFLD in rodent models. Targeting ACOC may therefore have potential therapeutic value in the treatment of NAFLD.
ACOC has been implicated in the regulation of insulin sensitivity, which refers to the ability of cells to respond to insulin and take up glucose from the bloodstream. Studies have shown that ACOC deficiency may impair insulin signaling and contribute to the development of insulin resistance, which is a key risk factor for metabolic diseases such as obesity and type 2 diabetes.
ACOC is part of a larger family of enzymes involved in fatty acid metabolism, including acyl-CoA dehydrogenases, enoyl-CoA hydratases, and beta-oxidation enzymes. Together, these enzymes work to break down long-chain fatty acids into smaller molecules that can be used for energy production.
ACOC expression can be regulated by a range of factors, including transcription factors, hormones, and dietary factors. For example, the high-fat diet has been shown to increase ACOC expression in the liver.
ACOC has been suggested as a potential target for the treatment of metabolic disorders such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD). Inhibitors of ACOC have been developed and tested in preclinical studies, although their potential as therapeutic agents is still under investigation.
ACOC inhibitors are still in the early stages of development, and their safety profile is not yet fully understood. However, potential side effects may include hepatotoxicity (liver toxicity), inflammation, and dyslipidemia (abnormal lipid levels). Further research is needed to determine the safety and efficacy of ACOC inhibitors as potential therapeutic agents.
ACOC is a peroxisomal enzyme consisting of four subunits, each containing one flavin adenine dinucleotide (FAD) cofactor. The enzyme catalyzes the oxidation of acyl-CoA molecules in a multi-step process involving the transfer of electrons from FAD to molecular oxygen.
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