ADCY4

  • Official Full Name

    adenylate cyclase 4

  • Synonyms

    ADCY4; adenylate cyclase 4; adenylate cyclase type 4; AC4; ADCY4_HUMAN; Adenylate cyclase type IV; Adenylyl cyclase 4; Adenylyl cyclase; ATP pyrophosphate lyase 4; ATP pyrophosphate lyase; ATP pyrophosphate-lyase 4; mKIAA4004;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Mouse Adcy4-6926M Recombinant Mouse Adcy4 protein, His & T7-tagged E.coli His/T7 Ile352~Val541 (Accession # Q91WF3)
Rat Adcy4-3175R Recombinant Rat Adcy4, GST-tagged E.Coli or Yeast GST 1064
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ADCY4 Related Signal Pathway

ADCY4 involved in several pathways and played different roles in them. We selected most pathways ADCY4 participated on our site, such as Purine metabolism, Rap signaling pathway, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADCY4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismAMPD3B;ENTPD8;ENPP1;POLD2;GUCY1A3;GMPR;PAPSS2;PDE1C;GMPS
Rap signaling pathwayGNAO1;PFN2;FGF16;GNAQ;LPAR2;PARD6A;FGF1;MAGI1;NRAS
Calcium signaling pathwayCACNA1BA;EDNRA;PRKACAA;ADRA1D;PPIF;ATP2A2;ADORA2AB;ATP2A1L;NOS2B
cGMP-PKG signaling pathwayNFATC4;ATP2B4;NFATC3;ATP1B2;INSR;CALML5;PLN;MYLK3;INS1
cAMP signaling pathwayAKT2;HCN4;RRAS2;GPR119;MAPK1;PPP1CC;PDE4B;PRKACA;HCAR2
Chemokine signaling pathwayPIK3CD;RAP1B;RHOA;ARRB2;AKT1;CCR1L1;PLCB2;CXCL11;RAC2
Phospholipase D signaling pathwayAVP;GRM5;GRM8;AKT2;RRAS2;MAPK1;PLA2G4C;GNAS;PTGFR
Oocyte meiosisYWHAG1;BTRC;CALM3;YWHAE1;INSB;YWHAZ;PPP3CB;CCNE1;CAMK2G1
Adrenergic signaling in cardiomyocytesCACNG8;SCN1BA;CACNA1SA;PPP2R1B;PLN;KCNQ1;CREB1A;CACNA2D4;CACNB2
Vascular smooth muscle contractionRHOAA;ADRA1BB;PLA2G2F;PPP1CBL;KCNMB1;MYH11;PLA2G4C;CALM3A;CYP4A14
Gap junctionTUBA1B;GNA15.4;PDGFAA;TUBA1A;TUBA8L2;CDK1;HRASB;TUBB2A;TUBA3C
Platelet activationITGB3;APBB1IP;GNAQ;GP6;PIK3R3;RHOA;MYLK4;VASP;MYLK
Circadian entrainmentGRIN2B;GNAQ;PRKACA;CALM2;RYR1;GNAS;CAMK2D;KCNJ6;GNG13
Retrograde endocannabinoid signalingNAPEPLD;GABRB1;SLC17A7;GNB3;GABRD;RIMS1;MAPK9;ITPR1;GABRG1
Glutamatergic synapseGNG11;GNAI1;GNB1;GNAS;GRIK4;SHANK2;HOMER3;PPP3CA;GNGT1
Cholinergic synapseFOS;FYN;CREB3L2;CREB5;GNB4;GNG10;ATF4;KCNJ4;GNG4
GABAergic synapseGABRA2;PLCL1;GNB4;GNB2;GABRA4;GABRR1;GNAI2;GABRB3;GABRR2
Taste transductionAdcy4;TAS2R16;TAS2R136;TAS2R144;ASIC2;TAS2R104;TAS2R120;PDE1A;TAS2R110
Inflammatory mediator regulation of TRP channelsIL1RAP;TRPV4;CAMK2B;PPP1CA;KLK1B4;CALM1;CYP2J2;CYP2C70;ACCN5
Insulin secretionGCG;GPR119;CREB3L1;ATP1A3;PRKCA;ATP1B2;KCNMB1;ATP1B4;SLC2A1
GnRH signaling pathwayPLA2G4AA;MAP2K2;PRKACB;GNA11;CALM3;MMP14B;CALM3B;CACNA1D;MAPK12A
Ovarian steroidogenesisAdcy4;FSHR;GDF9;PRKACB;ALOX5;IGF1;HSD3B1;FSHB;AKR1C3
Progesterone-mediated oocyte maturationPDE3B;CDC25B;CDC25C;INS;GNAI1;PIK3R3;ADCY1A;MAPK8B;RPS6KA6
Estrogen signaling pathwayITPR3;PLCB4;FKBP5;OPRM1;PIK3R5;RAF1;SRC;Adcy4;CALM3
MelanogenesisWNT4;ASIP;CAMK2D;GNAI2A;PRKACBA;WNT2;GNAI2B;PRKACAA;GSK3AA
Thyroid hormone synthesisPRKACA;TPO;CREB5;PRKCB;ATP1B4;PLCB3;GPX7;PRKACG;GPX3
Oxytocin signaling pathwayPLCB3;RYR1;MYLK;KRAS;RCAN1;CACNG8;PRKAA1;CACNB4;MAPK3
Regulation of lipolysis in adipocytesPNPLA2;FABP4;INSR;PIK3CA;PIK3CG;PIK3R5;LOC100328615;PRKG2;PLIN1
Aldosterone synthesis and secretionNR4A1;GNAQ;PRKACA;CAMK2D;PRKCB;ITPR3;ATF4;GNA11;CAMK4
Salivary secretionPRB1;AMY1B;ITPR1;AMY1A;CST5;Slc4a2;DMBT1;SLC9A1;MUC7
Gastric acid secretionCALM1;GAST;Slc4a2;PLCB4;ATP1A4;KCNE2;CALM3;ATP1A1;CAMK2G
Pancreatic secretionTRPC1;PLA2G3;CELA3B;ATP1B3;PLCB4;ATP1B4;SLC4A4;RAB8A;ATP2A1
Bile secretionCA2;CYP3A4;AQP4;SLCO1A2;SLCO1A6;BAAT;SCTR;SLC5A1;ADCY8
HTLV-I infectionCREM;ANAPC7;VDAC3;TBPL2;ANAPC4;GSK3B;AKT1;APC;SMAD2
Pathways in cancerTGFBR2;GSK3B;WNT2B;GNB2;EP300;LPAR3;FZD8;FZD1;CTNNA3
Dilated cardiomyopathyTPM3;ITGA6;Itga10&Itgb1;ADRB1;SGCB;ITGB6;CACNB3;ITGA2B;ITGA5

ADCY4 has several biochemical functions, for example, ATP binding, G-protein beta/gamma-subunit complex binding, adenylate cyclase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADCY4 itself. We selected most functions ADCY4 had, and list some proteins which have the same functions with ADCY4. You can find most of the proteins on our site.

Function Related Protein
ATP bindingATP1A1A.5;CLCN7;CCC2;SLC22A5;NVL;TBK1;CHD8;HSPA4B;EK1
G-protein beta/gamma-subunit complex bindingGNAQ;GNA12A;GNA11B;GNAI2;GNA14;GNAO1B;ADORA1;GNAI2A;GNAIA
adenylate cyclase activityADCY1B;ADCY3;Adcy4;ADCY9;ADCY2B;GNAS;ADCY1;ADCY1A;ADCY8
metal ion bindingKLF7A;AFP;ZFP536;LRP2;ZNF576.2;RPE65A;ACY3.2;FDX1B;PPM1AB
nucleotide bindingATP1A1A.4;RTCB;OASL2;NME2B.2;KITB;HSP70L;APLF;PUF60A;PABPC1L

ADCY4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADCY4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADCY4.

  • Q&As
  • Reviews

Q&As (13)

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Can Adcy4 be used as a biomarker for cancer diagnosis? 09/21/2022

Adcy4 has the potential to be used as a biomarker for some types of cancer. Its overexpression has been linked to several types of cancer, including breast, colorectal, and lung cancer. However, further research is needed to determine its exact role as a biomarker, and more studies are needed to validate its utility as a diagnostic tool.

Are there any potential side effects of targeting Adcy4 with drugs? 08/19/2022

There is always the potential for side effects with any drug targeting Adcy4. However, since this protein is expressed in a variety of tissues and plays a role in many different biological processes, any drug targeting Adcy4 would need to be designed specifically to minimize off-target effects.

Can Adcy4 be used as a therapeutic target in hypertension? 12/19/2020

Yes, Adcy4 is a promising therapeutic target in hypertension. Experimental studies have shown that inhibiting Adcy4 activity can reduce blood pressure in animal models. Developing drugs that specifically target Adcy4 could provide a new and effective treatment option for hypertension.

Is there any therapeutic potential for Adcy4 in neurological disorders? 08/19/2020

Yes, Adcy4 has potential therapeutic targets in neurological disorders such as Alzheimer's and Parkinson's. Studies suggest that Adcy4 plays a role in modulating neuronal excitability and plasticity, and targeting Adcy4 could lead to the development of new drugs for these disorders.

What techniques are used to study Adcy4 protein? 05/26/2020

Several techniques are used to study Adcy4 protein, including gene expression analysis, immunohistochemistry, Western blotting, and proteomic approaches such as mass spectrometry. In addition, animal models and cell culture systems are used to study the functional role of Adcy4 in various biological processes.

Could targeting Adcy4 with drugs have potential side effects? 11/14/2019

Yes, targeting Adcy4 with drugs could potentially have side effects, especially if the target is not selective. Adcy4 has a role in multiple cellular processes, and therefore it is crucial to carefully evaluate the potential drugs and their effects on other cellular processes to lessen unwanted side effects.

How long do researchers expect it will take to develop a drug that targets Adcy4? 03/15/2019

Drug development is a complex and time-consuming process that can take several years or even decades. It depends on many factors, including the availability of funding, the success of preclinical studies, and the safety and efficacy of the drug in clinical trials. However, because Adcy4 is a promising target for several different diseases, there is likely to be ongoing research in this area for years to come.

Can Adcy4 protein be used as a diagnostic marker for diseases? 09/28/2018

Adcy4 protein expression levels could potentially be used as a diagnostic marker for some diseases. For example, increased levels of Adcy4 have been associated with heart failure, and measuring Adcy4 expression may help with early diagnosis and patient monitoring.

Could Adcy4 research lead to the development of new drugs? 04/09/2018

Yes, Adcy4 research could lead to the development of new drugs that target cAMP signaling pathways in a more specific and effective way than currently available treatments. This could lead to improved outcomes for patients with diseases such as hypertension and heart failure.

Could personalized medicine approaches be developed based on Adcy4 expression? 06/09/2017

Yes, personalized medicine approaches could potentially be developed based on Adcy4 expression levels. Measuring Adcy4 expression could help identify patients who are more likely to respond to certain treatments and stratify patients into specific subgroups for more targeted therapies.

Can Adcy4 be used to develop new treatments for heart disease? 03/19/2017

Yes, Adcy4 is a promising target for developing new treatments for heart disease. The protein plays a role in regulating cardiac function and has been linked to heart failure and other cardiovascular diseases. Inhibiting Adcy4 activity could help to improve cardiac function and reduce the risk of heart failure.

What are some potential applications of Adcy4 protein in medicine? 03/10/2017

Adcy4 protein has potential applications in medicine for the treatment of several diseases, such as hypertension, heart failure, and certain types of cancer. Understanding the role of Adcy4 in these diseases could lead to the development of new druggable targets and therapies.

How is Adcy4 protein regulated in the body? 11/07/2016

Adcy4 protein is regulated by a variety of mechanisms in the body. Some regulators of Adcy4 expression include transcription factors, post-translational modifications such as phosphorylation, and various signaling pathways that can either activate or inhibit Adcy4 activity.

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