AKR1B15
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Synonyms
AKR1B10L;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | AKR1B15-3267H | Recombinant Human AKR1B15, His-tagged | E.Coli or Yeast | His | 344 |
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- Involved Pathway
- Protein Function
- Interacting Protein
AKR1B15 involved in several pathways and played different roles in them. We selected most pathways AKR1B15 participated on our site, such as Estrogen biosynthesis, Metabolism, Metabolism of lipids and lipoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1B15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Estrogen biosynthesis | AKR1B15;HSD17B11;CYP19A1 |
| Metabolism | HAS1;PNP5B;HPSE;NFYBA;ATP5S;FABP11B;YY2;ARSE;CKBA |
| Metabolism of lipids and lipoproteins | SLC25A20;MED10;ACAD11;CETP;FAAH2B;BCHE;ALOX5AP;SGMS2;NFYBA |
| Metabolism of steroid hormones and vitamin D | CYP2R1;CYP24A1;HSD17B11;CYP27B1;GC;STARD5;AKR1B15;PPP1R2 |
AKR1B15 has several biochemical functions, for example, estradiol 17-beta-dehydrogenase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1B15 itself. We selected most functions AKR1B15 had, and list some proteins which have the same functions with AKR1B15. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| estradiol 17-beta-dehydrogenase activity | HSD17B12A;HSD17B10;HSD17B7;HSD17B8;RDH8B;H2-KE6;HSD17B1;HSD17B2;HSD17B12 |
| oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | CTBP2;GPD1B;LDHBB;UEVLD;GRHPRB;GPD1C;MDH1B;SDR42E1;LDHBA |
AKR1B15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1B15 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1B15.
- Reviews
- Q&As
Customer Reviews (4)
Write a reviewAKR1B15 has similar activity to the native protein and is able to perform the expected biological functions.
This protein is highly expressed and can efficiently synthesize a large number of target proteins in host cells.
AKR1B15 was stable in solution and not easily aggregated or inactivated.
Highly purified and was not doped with other proteins or impurities.
Q&As (11)
Ask a questionKetose reductase is overexpressed in some cancer types, such as lung and breast cancer. There may be potential for ketose reductase as a cancer therapeutic target, although more research is still needed to determine its feasibility for clinical use.
While the exact role of AKR1B15 in disease is not well understood, altered expression or activity of AKR1B15 has been associated with certain types of cancers, such as hepatocellular carcinoma.
AKR1B15 refers to Aldo-keto reductase family 1 member B15, which is a protein encoded by the AKR1B15 gene. AKR1B15 belongs to the aldo-keto reductase (AKR) superfamily and is involved in the metabolism of various endogenous compounds and xenobiotics.
It is primarily expressed in the liver, but can also be found in other tissues such as the kidney and lung.
AKR1B15 is involved in the regulation of glucose metabolism in humans. It is capable of converting glucose to glucuronic acid and reducing glucuronic acid to glucose. This process is important for maintaining normal blood sugar levels.AKR1B15 also has antioxidant stress effects. It can protect cells from oxidative stress by scavenging free radicals and alleviating oxidative damage.
KR1B15 shares common structural features with other members of the AKR family, including a conserved NADPH-binding site and a catalytic domain responsible for its enzymatic activity.
The AKR1B15 protein, a member of the aldo-keto reductase (AKR) family, has not been extensively studied, and its involvement in cell signaling pathways is currently not well-defined. As of my knowledge, there are no specific cell signaling pathways reported to involve AKR1B15. However, it's worth noting that other members of the AKR family, such as AKR1B1 and AKR1B10, have been implicated in various cellular processes and signaling pathways, including those related to glucose metabolism, lipid metabolism, inflammation, and oxidative stress. Further research is necessary to determine the exact signaling pathways associated with AKR1B15.
Ketose reductase may be involved in the regulation of some inflammatory processes. The researchers believe that this gene may be involved in the development of diseases such as inflammatory bowel disease.
There is a link between AKR1B15 and diabetes. The study found that this enzyme may be involved in metabolic disorders caused by hyperglycemia and is associated with the occurrence and development of diabetic complications such as retinopathy and neuropathy.In addition, AKR1B15 is also involved in the metabolism and detoxification of certain drugs. It is involved in the metabolism of several endogenous and exogenous compounds, including hormones, ketone bodies, and environmental toxins.
KR1B15 has been shown to have broad substrate specificity, including the reduction of carbonyl compounds like steroids, prostaglandins, and xenobiotics.
There may be an association between ketose reductase and the development of diabetes mellitus. Studies have shown that ketose reductase is involved in the regulation of intracellular glucose metabolism and insulin secretion. Further studies may reveal the role of this gene in the pathogenesis of diabetes.
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