AKR1C1

  • Official Full Name

    aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)

  • Overview

    This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

  • Synonyms

    AKR1C1;aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1;20-alpha (3-alpha)-hydroxysteroid dehydrogenase);DDH1;aldo-keto reductase family 1 member C1;DD1;DDH;HAKRC;MBAB;2-dihydrobenzene-1;2-diol dehydrogenase;20 alpha (3 alpha) hydroxysteroid dehydrogenase;20 ALPHA HSD;20 alpha hydroxysteroid dehydrogenase;20-alpha-HSD;20-alpha-hydroxysteroid dehydrogenase;20ALPHAHSD;2ALPHAHSD;AK1C1;AK1C1_HUMAN;Aldo keto reductase family 1 member C1;C9;Chlordecone reductase homolog;Chlordecone reductase homolog HAKRC;DD1/DD2;Dihydrodiol dehydrogenase 1;Dihydrodiol dehydrogenase 1/2;dihydrodiol dehydrogenase isoform DD1;H37;HBAB;Hepatic dihydrodiol dehydrogenase;High affinity hepatic bile acid-binding protein;High-affinity hepatic bile acid-binding protein;Indanol dehydrogenase;MGC8954;Trans-1;Trans-1,2 dihydrobenzene 1,2 diol dehydrogenase;Type II 3 alpha hydroxysteroid dehydrogenase;OTTHUMP00000018992;OTTHUMP00000018993;aldo-keto reductase C;20 alp;H-37;2-ALPHA-HSD

Recombinant Proteins

  • Human
  • Cynomolgus
  • Rhesus macaque
  • E.coli
  • Mammalian Cells
  • HEK293
  • In Vitro Cell Free System
  • His
  • Non
  • Avi
  • Fc
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
AKR1C1-2028H Recombinant Human AKR1C1, His-tagged E.coli Human His
AKR1C1-27157TH Recombinant Human AKR1C1, His-tagged E.coli Human His Full L. 1-323 a.a.
AKR1C1-289C Recombinant Cynomolgus AKR1C1 Protein, His-tagged Mammalian Cells Cynomolgus His
AKR1C1-293R Recombinant Rhesus monkey AKR1C1 Protein, His-tagged Mammalian Cells Rhesus macaque His
AKR1C1-48HCL Recombinant Human AKR1C1 cell lysate Human Non
AKR1C1-121R Recombinant Rhesus Macaque AKR1C1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
AKR1C1-121R-B Recombinant Rhesus Macaque AKR1C1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
AKR1C1-1366HF Recombinant Full Length Human AKR1C1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 323 amino acids
AKR1C1-39C Recombinant Cynomolgus Monkey AKR1C1 Protein, His (Fc)-Avi-tagged HEK293 Cynomolgus Avi&Fc&His
AKR1C1-39C-B Recombinant Cynomolgus Monkey AKR1C1 Protein Pre-coupled Magnetic Beads HEK293 Cynomolgus

    Involved Pathway

    AKR1C1 involved in several pathways and played different roles in them. We selected most pathways AKR1C1 participated on our site, such as Adaptive Immune System,Aldosterone synthesis and secretion,Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1C1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alzheimers disease BAD,CASP8,GRIN2A,UQCRB,COX7B2,GAPDH,NDUFB6,ATP5O,ATP5D,CALML5
    Calcium signaling pathway ADCY2B,P2RX3B,HTR2C,VDAC3,PPP3CB,PPIFB,PPP3R1,PHKG2,MLCK2,P2RX5
    Adaptive Immune System ITK,LILRB4,HCST,TREM1,EGFR,PTBP3,PPIAL4A,GM11711,KIF15,LILRA1
    Antigen activates B Cell Receptor (BCR) leading to generation of second messengers IGKV1-5,IGHM,PIK3AP1,IGKC,STIM1B,ITPR2,IGLC2,BLK,AHCYL1,SRMS
    Cholinergic synapse CHRM1,GNB3,AKT1,PRKACA,FYN,KCNJ4,GNG3,CHRM5,CAMK4,PLCB2
    Calcium Regulation in the Cardiac Cell RGS20,CASQ1B,RGS18,RGS5A,CX34.4,CHRM3,RGS4,RGS10,CHRM5,GJB4
    Aldosterone synthesis and secretion AGTR1A,CREB3L1,Adcy4,ATF4,GNA11,KCNK9,ATF1,ADCY3,CAMK2A,HSD3B5
    Circadian entrainment PER1,GNGT1,GNG2,GRIN2B,GNAI2,CALM3,MTNR1A,CAMK2B,GUCY1B3,GNG13

    Protein Function

    AKR1C1 has several biochemical functions, for example, calcium channel activity,calcium ion binding,inositol 1,3,4,5 tetrakisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1C1 itself. We selected most functions AKR1C1 had, and list some proteins which have the same functions with AKR1C1. You can find most of the proteins on our site.

    Function Related Protein
    inositol 1,3,4,5 tetrakisphosphate binding ADAP2,SYT2,ADAP1,ITPR3
    phosphatidylinositol binding MYO1E,PLD1A,SNX18A,PXK,TULP4,SNX25,PLD2,GRB7,SNX7,ING2
    inositol 1,4,5 trisphosphate binding TRPC2B,CYTH2,TRPC6A,TRPC3,TRPC7,TRPC4,RPH3A,PLCL1,TRPC5A,TRPC5
    inositol hexakisphosphate binding ITPR3
    intracellular ligand-gated calcium channel activity ITPR1,TRPA1,ITPR3,RYR2
    ion channel activity CHRNB3A,GRIN2A,GRIA4B,KCNK3,TRPC5A,CLCN6,P2RX3A,SCN4AA,KCNC3A,CLCN4-2
    inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity ITPR2,ITPR3,ITPR1
    calcium channel activity CACNG2B,GRIN2B,CACNG8A,SLC24A1,CACNA1SB,TRPV3,SLC24A4,CHRNA9,CACNB2,CACFD1
    protein binding FAM21C,RBM15B,TACR3,COQ7,SUGT1,OLA1,FNTB,IL1RN,KTN1,SF3A1

    Interacting Protein

    AKR1C1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1C1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1C1.

    PTPN3;MAPK3;COMMD8;FN1

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