AKR1C1
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Official Full Name
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) -
Overview
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
Recombinant Proteins
- Human
- Cynomolgus
- Rhesus macaque
- E.coli
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- Non
- Avi
- Fc
- GST
Involved Pathway
AKR1C1 involved in several pathways and played different roles in them. We selected most pathways AKR1C1 participated on our site, such as Adaptive Immune System,Aldosterone synthesis and secretion,Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1C1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | CTSD,SIGLEC11,ATG7,PJA1,NCR3LG1,KLHL20,TREML2,UBE2V1,EGF,RACGAP1 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | IGLC2,ITPR2,PIK3AP1,BLK,IGKV1-5,STIM1B,AHCYL1,IGKC,SRMS,IGHM |
| Circadian entrainment | GNGT2,PER3,PLCB4,RPS6KA5,GNGT1,RYR2,PRKACG,PRKG2,FOS,GRIN2A |
| Calcium signaling pathway | RYR1,PLCG1,P2RX5,PHKA2,ADRA1BB,GRIN2A,CACNA1SA,PPP3R1B,TACR1,CCKAR |
| Aldosterone synthesis and secretion | DDX1,AGTR1,GNAS,NR4A2,PRKACA,HSD3B5,CALML3,MC2R,CALML5,PLCB3 |
| Cholinergic synapse | PIK3R5,CHRM5,CHRNB4,KCNQ5,PIK3CA,CHRNA4,GNAQ,CAMK4,PLCB4,KCNQ1 |
| Alzheimers disease | COX6A2,NDUFAB1,SNCA,PLCB1,PSEN2,NDUFS3,IL1B,PSEN1,NDUFB7,UQCRQ |
| Calcium Regulation in the Cardiac Cell | CHRM5,CHRM2,GJC2,GJB3,RGS19,ADRa1A,RGS20,RGS14A,RGS7,YWHAQ |
Protein Function
AKR1C1 has several biochemical functions, for example, calcium channel activity,calcium ion binding,inositol 1,3,4,5 tetrakisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1C1 itself. We selected most functions AKR1C1 had, and list some proteins which have the same functions with AKR1C1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| intracellular ligand-gated calcium channel activity | RYR2,ITPR1,ITPR3,TRPA1 |
| inositol 1,4,5 trisphosphate binding | CYTH2,PLCL1,RPH3A,TRPC2,TRPC2B,TRPC5A,TRPC6,TRPC6A,TRPC5,TRPC3 |
| calcium ion binding | RHOT2,LRP2A,PLCB1,PVALB7,EHD2,CCDC47,FSTL1A,SMOC1,DUOX2,NOX5 |
| inositol 1,3,4,5 tetrakisphosphate binding | ADAP1,ITPR3,SYT2,ADAP2 |
| calcium channel activity | CACNA1SA,TRPN1,P2RX1,CACNG1A,TRPC2B,ORAI1B,TRPM1,CUL5,TRPM2,CACNG2B |
| ion channel activity | CACNA1C,KCNH1B,ASIC4,TRPV2,CHRNB3,FXYD6,KCNK3,HTR3B,GRIA2B,GRIA2A |
| inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity | ITPR3,ITPR1,ITPR2 |
| protein binding | RUFY1,NIPAL1,DPPA4,C18orf1,TRIM28,KIF18B,RAF1,PTPRA,TWIST1,HGD |
| inositol hexakisphosphate binding | ITPR3 |
Interacting Protein
AKR1C1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1C1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1C1.
PTPN3;MAPK3;COMMD8;FN1
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