• Official Full Name

    aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)

  • Background

    This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
  • Synonyms

    AKR1C1; aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase); DDH1; aldo-keto reductase family 1 member C1; DD1; DDH; HAKRC; MBAB; 2-dihydrobenzene-1; 2-diol dehydrogenase; 20 alpha (3 alpha) hydroxysteroid dehydrogenase; 20 ALPHA HSD; 20 alpha hydroxysteroid dehydrogenase; 20-alpha-HSD; 20-alpha-hydroxysteroid dehydrogenase; 20ALPHAHSD; 2ALPHAHSD; AK1C1; AK1C1_HUMAN; Aldo keto reductase family 1 member C1; C9; Chlordecone reductase homolog; Chlordecone reductase homolog HAKRC; DD1/DD2; Dihydrodiol dehydrogenase 1; Dihydrodiol dehydrogenase 1/2; dihydrodiol dehydrogenase isoform DD1; H37; HBAB; Hepatic dihydrodiol dehydrogenase; High affinity hepatic bile acid-binding protein; High-affinity hepatic bile acid-binding protein; Indanol dehydrogenase; MGC8954; Trans-1; Trans-1,2 dihydrobenzene 1,2 diol dehydrogenase; Type II 3 alpha hydroxysteroid dehydrogenase; OTTHUMP00000018992; OTTHUMP00000018993; aldo-keto reductase C; 20 alp; H-37; 2-ALPHA-HSD;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Cynomolgus Monkey
    • Human
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • In Vitro Cell Free System
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • N/A
    Species Cat.# Product name Source (Host) Tag Price
    Human AKR1C1-27156TH Recombinant Human AKR1C1, His-tagged E.coli His
    Human AKR1C1-411H Recombinant Human AKR1C1 Protein, GST-tagged Wheat Germ GST
    Human AKR1C1-27157TH Recombinant Human AKR1C1, His-tagged E.coli His
    Human AKR1C1-2028H Recombinant Human AKR1C1, His-tagged E.coli His
    Human AKR1C1-48HCL Recombinant Human AKR1C1 cell lysate N/A
    Human AKR1C1-1366HF Recombinant Full Length Human AKR1C1 Protein, GST-tagged In Vitro Cell Free System GST
    Cynomolgus Monkey AKR1C1-289C Recombinant Cynomolgus AKR1C1 Protein, His-tagged Mammalian Cell His
    Cynomolgus Monkey AKR1C1-39C Recombinant Cynomolgus Monkey AKR1C1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Cynomolgus Monkey AKR1C1-39C-B Recombinant Cynomolgus Monkey AKR1C1 Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque AKR1C1-293R Recombinant Rhesus monkey AKR1C1 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque AKR1C1-121R-B Recombinant Rhesus Macaque AKR1C1 Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque AKR1C1-121R Recombinant Rhesus Macaque AKR1C1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    • Involved Pathway
    • Protein Function
    • Interacting Protein

    AKR1C1 involved in several pathways and played different roles in them. We selected most pathways AKR1C1 participated on our site, such as Adaptive Immune System, Aldosterone synthesis and secretion, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1C1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Aldosterone synthesis and secretionPLCB3;CALM4;PLCB2;PRKCA;HSD3B5;PRKCE;ATF6B;PRKACA;PRKCG
    Alzheimers diseaseAPOE;ATP2A3;ATP5G3;NDUFV3;COX7B;COX6C;CASP7;UQCRC2;COX5B
    Antigen activates B Cell Receptor (BCR) leading to generation of second messengersITPR2;SRMS;PIK3AP1;IGLC2;IGHM;IGKC;IGKV1-5;AHCYL1;BLK
    Calcium Regulation in the Cardiac CellANXA6;RGS10;GJB2;RGS5A;PKIG;YWHAQ;RGS5B;CX44.1;GJA10
    Calcium signaling pathwayP2RX1;HTR2C;DRD5;CALM2A;GNA11B;PPP3CC;PTAFR;PPIF;SLC8A2
    Cholinergic synapseCHRNA3;HRAS;PLCB2;ATF4;GNG10;GNB4;GNG7;GNGT2;CREB3L3
    Circadian entrainmentRYR1;GNG8;PLCB3;GNAO1;PRKACA;GNAI3;CALM3;PRKG1;CALML3

    AKR1C1 has several biochemical functions, for example, calcium channel activity, calcium ion binding, inositol 1,3,4,5 tetrakisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1C1 itself. We selected most functions AKR1C1 had, and list some proteins which have the same functions with AKR1C1. You can find most of the proteins on our site.

    Function Related Protein
    calcium channel activitySLC24A2;PKD2L1;RYR2;TRPC2B;TRPC4B;PSEN1;CACNG7A;TRPM2;PKD1
    calcium ion bindingEPD;PCDH2AA15;TNNC1A;ANXA5B;Shh;CAPSLB;SLC25A25A;MELK;SYT2
    inositol 1,3,4,5 tetrakisphosphate bindingSYT2;ITPR3;ADAP1;AKR1C1;ADAP2
    inositol 1,4,5 trisphosphate bindingTRPC1;AKR1C1;TRPC5;TRPC4;TRPC2;TRPC6A;TRPC6;RPH3A;TRPC7A
    inositol 1,4,5-trisphosphate-sensitive calcium-release channel activityITPR2;AKR1C1;ITPR3;ITPR1
    inositol hexakisphosphate bindingAKR1C1;ITPR3
    intracellular ligand-gated calcium channel activityRYR2;ITPR3;ITPR1;TRPA1;AKR1C1
    phosphatidylinositol bindingP2RX2;PXK;HS1BP3;SNX31;SNX1A;HIP1RB;MTM1;NOXO1;HIP1R

    AKR1C1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1C1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1C1.


    • Q&As
    • Reviews

    Q&As (15)

    Ask a question
    Are there any diseases associated with mutations or dysregulation of AKR1C1? 04/14/2023

    Mutations or dysregulation of AKR1C1 have been implicated in several diseases. For example, deficiency in AKR1C1 activity can lead to cortisone reductase deficiency type 1, a rare inherited disorder characterized by cortisol deficiency and excessive androgen production. AKR1C1 dysregulation has also been associated with certain types of cancer, as mentioned earlier. Furthermore, alterations in AKR1C1 expression or activity have been observed in conditions such as endometriosis, prostate hyperplasia, and obesity, suggesting potential roles in these diseases as well.

    What are the physiological functions of AKR1C1? 03/16/2023

    In addition to its role in steroid hormone metabolism, AKR1C1 likely has other physiological functions. It may be involved in maintaining the redox balance within cells by catalyzing the reduction of aldehydes and ketones. Additionally, AKR1C1 has been suggested to play a role in inflammation, oxidative stress, and tissue development, although further investigation is needed to fully understand these functions.

    Are there any therapeutic strategies targeting AKR1C1 in cancer treatment? 10/30/2022

    Yes, targeting AKR1C1 has been explored as a therapeutic strategy in cancer treatment. As mentioned earlier, AKR1C1 inhibitors are being developed to disrupt the balance of steroid hormones in the tumor microenvironment and potentially inhibit tumor growth. In addition, AKR1C1 inhibitors may sensitize cancer cells to hormone therapy or other anticancer drugs. Further research is needed to determine the efficacy and safety of these therapeutic strategies, but they represent a promising approach in cancer therapy.

    Are there any known natural or synthetic compounds that can modulate AKR1C1 activity? 08/14/2022

    Yes, there are several natural and synthetic compounds that have been shown to modulate AKR1C1 activity. For example, some flavonoids and polyphenols found in fruits and vegetables have been identified as AKR1C1 inhibitors. Certain drugs, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and statins, can also affect AKR1C1 activity. In addition, endogenous compounds like retinoic acid and bile acids have been shown to regulate AKR1C1 expression and activity. The identification and characterization of these compounds provide potential avenues for therapeutic interventions targeting AKR1C1.

    Can AKR1C1 be used as a biomarker in disease diagnosis? 11/19/2021

    AKR1C1 has been investigated as a potential biomarker in various diseases. Its altered expression or activity in certain cancers, such as breast and prostate cancer, has shown promise as a diagnostic or prognostic marker. However, further research is needed to validate its utility as a biomarker and determine its specificity and sensitivity in different disease contexts.

    Does AKR1C1 have any interactions with other proteins or signaling pathways? 11/14/2021

    Yes, AKR1C1 has been found to interact with other proteins and participate in various signaling pathways. For example, AKR1C1 has been shown to interact with nuclear receptors, such as the progesterone receptor and androgen receptor, influencing their transcriptional activity. AKR1C1 can also interact with enzymes involved in steroid hormone metabolism and drug metabolism, forming metabolic networks within cells. Understanding these interactions can provide insights into the complex roles of AKR1C1 in cellular processes.

    Are there any inhibitors or activators of AKR1C1? 12/02/2020

    Yes, several inhibitors and activators of AKR1C1 have been identified. Some inhibitors include flufenamic acid, indomethacin, and medroxyprogesterone acetate. These compounds can selectively bind to AKR1C1 and inhibit its enzymatic activity. On the other hand, some activators, such as NADPH and ATP, are required cofactors for the enzymatic function of AKR1C1.

    Is there ongoing research on AKR1C1? 03/02/2020

    Yes, AKR1C1 continues to be an active area of research. Scientists are investigating its role in various diseases, including cancer, and exploring its potential as a therapeutic target or biomarker. The structural and functional characterization of AKR1C1 is also an important focus, as it helps in understanding its enzymatic mechanisms and potential for drug development. Additionally, the identification of genetic polymorphisms and regulatory pathways associated with AKR1C1 is an ongoing area of investigation.

    Are there any known therapeutic applications of AKR1C1 inhibitors or activators? 12/26/2019

    AKR1C1 inhibitors have been explored for their potential therapeutic applications, primarily in the context of cancer treatment. By inhibiting AKR1C1, it is hoped that the balance of steroid hormones within the tumor microenvironment can be disrupted, leading to decreased tumor growth or increased sensitivity to hormone therapy. The use of AKR1C1 inhibitors in combination with other therapeutic agents is also being investigated. However, it is important to note that the development of AKR1C1 inhibitors for clinical use is still in the early stages.

    How is AKR1C1 involved in steroid hormone metabolism? 04/18/2019

    AKR1C1 is a key enzyme involved in the metabolism of steroid hormones. It primarily catalyzes the reduction of 5α-dihydrosteroids and 5β-dihydrosteroids. For example, AKR1C1 converts testosterone to dihydrotestosterone (DHT), a potent androgen. It also participates in the metabolism of progesterone, cortisone, and other steroid hormones. The activity of AKR1C1 in steroid hormone metabolism helps maintain the balance of these hormones and is crucial for normal physiological functions.

    Can AKR1C1 be a potential therapeutic target? 02/25/2019

    AKR1C1 has been considered as a potential therapeutic target in certain diseases, including cancer. Inhibitors of AKR1C1 have been explored for their potential anticancer properties by targeting steroid hormone metabolism or reversing drug resistance. However, further research is needed to fully understand the therapeutic potential and safety of targeting AKR1C1.

    How is AKR1C1 regulated? 09/21/2017

    AKR1C1 expression and activity can be regulated at multiple levels. Transcriptional regulation is one mechanism, where factors such as hormones, cytokines, and growth factors can influence AKR1C1 gene expression. Epigenetic modifications, such as DNA methylation and histone modifications, can also affect AKR1C1 expression. Additionally, post-transcriptional regulation, including alternative splicing, microRNA-mediated regulation, and protein stabilization or degradation, can modulate AKR1C1 activity.

    Is there any known genetic polymorphism in AKR1C1? 08/02/2017

    Yes, several genetic polymorphisms have been identified in the AKR1C1 gene. These polymorphisms can lead to variations in AKR1C1 expression or activity, which may contribute to interindividual differences in steroid hormone metabolism and response to drugs. The functional implications of these polymorphisms are still being studied.

    Are there any known functional variants of AKR1C1? 09/14/2016

    Yes, there are known functional variants of AKR1C1 that have been identified through genetic studies. For example, certain single nucleotide polymorphisms (SNPs) in the AKR1C1 gene have been associated with altered enzyme activity or expression. These functional variants can impact the metabolism of steroid hormones and other substrates of AKR1C1, potentially influencing disease risk or drug response. Understanding the functional implications of these variants is important in personalized medicine and optimizing treatment strategies.

    Can AKR1C1 polymorphisms influence drug response or metabolism? 06/06/2016

    Yes, AKR1C1 polymorphisms have been associated with inter-individual differences in drug response and metabolism. These genetic variations can affect the function and activity of AKR1C1, leading to altered drug metabolism and response. For example, certain AKR1C1 polymorphisms have been linked to variations in the metabolism of drugs such as tamoxifen and nonsteroidal anti-inflammatory drugs (NSAIDs). Understanding the impact of AKR1C1 polymorphisms on drug metabolism can help in optimizing drug therapies and improving patient outcomes.

    Customer Reviews (4)

    Write a review

      Its high purity and integrity provide the necessary assurance for consistent and reliable results, enabling me to achieve precise and meaningful outcomes in my research. -


        I am confident in the manufacturer's ability to deliver outstanding technical support. -


          By incorporating the AKR1C1 protein into my experiments, I am confident that I am utilizing a product that meets the highest standards of quality and performance. -


            The AKR1C1 protein demonstrates exceptional quality, making it an ideal candidate to fulfill my experimental requirements. -

            Ask a Question for All AKR1C1 Products

            Required fields are marked with *

            My Review for All AKR1C1 Products

            Required fields are marked with *


            Stay Updated on the
            Latest Bioscience Trends

            Copyright © 2023 Creative BioMart. All Rights Reserved.

            Terms and Conditions        Privacy Policy