AKR1C1 Protein


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Official Full Name aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
Background This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
Synonyms AKR1C1; aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase); DDH1; aldo-keto reductase family 1 member C1; DD1; DDH; HAKRC; MBAB; 2-dihydrobenzene-1; 2-diol dehydrogenase; 20 alpha (3 alpha) hydroxysteroid dehydrogenase; 20 ALPHA HSD; 20 alpha hydroxysteroid dehydrogenase; 20-alpha-HSD; 20-alpha-hydroxysteroid dehydrogenase; 20ALPHAHSD; 2ALPHAHSD; AK1C1; AK1C1_HUMAN; Aldo keto reductase family 1 member C1; C9; Chlordecone reductase homolog; Chlordecone reductase homolog HAKRC; DD1/DD2; Dihydrodiol dehydrogenase 1; Dihydrodiol dehydrogenase 1/2; dihydrodiol dehydrogenase isoform DD1; H37; HBAB; Hepatic dihydrodiol dehydrogenase; High affinity hepatic bile acid-binding protein; High-affinity hepatic bile acid-binding protein; Indanol dehydrogenase; MGC8954; Trans-1; Trans-1,2 dihydrobenzene 1,2 diol dehydrogenase; Type II 3 alpha hydroxysteroid dehydrogenase; OTTHUMP00000018992; OTTHUMP00000018993; aldo-keto reductase C; 20 alp; H-37; 2-ALPHA-HSD
    • Species :
    • Cynomolgus Monkey
    • Human
    • Rhesus Macaque
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AKR1C1-2028H Recombinant Human AKR1C1, His-tagged E.coli His
    Human AKR1C1-27156TH Recombinant Human AKR1C1, His-tagged E.coli His
    Human AKR1C1-27157TH Recombinant Human AKR1C1, His-tagged E.coli His
    Human AKR1C1-411H Recombinant Human AKR1C1 Protein, GST-tagged Wheat Germ GST
    Human AKR1C1-48HCL Recombinant Human AKR1C1 cell lysate N/A
    Cynomolgus Monkey AKR1C1-289C Recombinant Cynomolgus AKR1C1 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque AKR1C1-293R Recombinant Rhesus monkey AKR1C1 Protein, His-tagged Mammalian Cell His

    AKR1C1 involved in several pathways and played different roles in them. We selected most pathways AKR1C1 participated on our site, such as Adaptive Immune System, Aldosterone synthesis and secretion, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1C1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System MAPKAP1; CD200R4; SIGLEC9; RNF138; SPSB1; CD300LH; CTSL1; MICA; CDKN1A; RAET1E
    Aldosterone synthesis and secretion SCARB1; ORAI1; Adcy4; LDLR; CREB3L4; CALM2; KCNK3; HSD3B4; PRKCG; CALM1
    Alzheimers disease NCSTN; SDHD; NDUFB5; NDUFA8; NDUFC1; ERN1; ITPR3; GRIN2A; NDUFAB1; APOE
    Antigen activates B Cell Receptor (BCR) leading to generation of second messengers PIK3AP1; IGLC2; IGKV1-5; IGHM; BLK; ITPR2; AHCYL1; IGKC; SRMS; AKR1C1
    Calcium Regulation in the Cardiac Cell GNB5B; ADRA1B; CX44.1; CCDC102A; RGS4; RGS5B; RGS14A; CASQ1; GJB6; RGS5
    Calcium signaling pathway GNA11B; PLCB4; HTR5AL; PRKACAA; GRIN2C; PLCG1; P2RX4B; SLC8A3; ADRB2; GRIN1B
    Cholinergic synapse GNG13; KCNJ2; PLCB1; GNB1; BCL2; CHRNA6; GNG4; GNB2; MAPK1; PIK3CG
    Circadian entrainment Adcy4; PER1; GRIA2; PLCB3; ADCYAP1R1; GNG2; CACNA1H; CACNA1G; GNG5; GNAO1

    AKR1C1 has several biochemical functions, for example, calcium channel activity, calcium ion binding, inositol 1,3,4,5 tetrakisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1C1 itself. We selected most functions AKR1C1 had, and list some proteins which have the same functions with AKR1C1. You can find most of the proteins on our site.

    Function Related Protein
    calcium channel activity TRPM2; SLC24A1; PKD1; CACNA1SA; RYR1; CATSPER2; TRPV4; CACNA1BA; CACNG1A; TMEM37
    calcium ion binding PLS3; ENPP1; KCNIP3A; LRP2; SYT17; CALRL2; MGP; THBS2; SGCA; PVALB4
    inositol 1,3,4,5 tetrakisphosphate binding AKR1C1; ADAP1; ITPR3; ADAP2; SYT2
    inositol 1,4,5 trisphosphate binding PLCL1; TRPC2B; TRPC7A; TRPC3; TRPC6A; TRPC2; TRPC4; TRPC5A; CYTH2; RPH3A
    inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity AKR1C1; ITPR2; ITPR1; ITPR3
    inositol hexakisphosphate binding AKR1C1; ITPR3
    intracellular ligand-gated calcium channel activity ITPR3; ITPR1; RYR2; AKR1C1; TRPA1
    ion channel activity AKR1C1; TRPM1B; GRIA3A; P2RX3B; CLCNKB; GRIA3B; KCNQ2A; KCNS3A; SCN12AB; P2RX4B
    phosphatidylinositol binding SNX27A; SLC12A9; SNX33; PLD2; SNX10B; ESYT2; SNX15; AKR1C1; SNX13; NISCH
    protein binding SRGAP3; AMBP; DARS2; CDCP1; NDUFAF3; JAG1; NPM1; GATA3; DFFA; SEPT9

    AKR1C1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1C1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1C1.


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