AKR1C1
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Official Full Name
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) -
Overview
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. -
Synonyms
AKR1C1;aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1;20-alpha (3-alpha)-hydroxysteroid dehydrogenase);DDH1;aldo-keto reductase family 1 member C1;DD1;DDH;HAKRC;MBAB;2-dihydrobenzene-1;2-diol dehydrogenase;20 alpha (3 alpha) hydroxysteroid dehydrogenase;20 ALPHA HSD;20 alpha hydroxysteroid dehydrogenase;20-alpha-HSD;20-alpha-hydroxysteroid dehydrogenase;20ALPHAHSD;2ALPHAHSD;AK1C1;AK1C1_HUMAN;Aldo keto reductase family 1 member C1;C9;Chlordecone reductase homolog;Chlordecone reductase homolog HAKRC;DD1/DD2;Dihydrodiol dehydrogenase 1;Dihydrodiol dehydrogenase 1/2;dihydrodiol dehydrogenase isoform DD1;H37;HBAB;Hepatic dihydrodiol dehydrogenase;High affinity hepatic bile acid-binding protein;High-affinity hepatic bile acid-binding protein;Indanol dehydrogenase;MGC8954;Trans-1;Trans-1,2 dihydrobenzene 1,2 diol dehydrogenase;Type II 3 alpha hydroxysteroid dehydrogenase;OTTHUMP00000018992;OTTHUMP00000018993;aldo-keto reductase C;20 alp;H-37;2-ALPHA-HSD
Recombinant Proteins
- Human
- Cynomolgus
- Rhesus macaque
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Avi
- Fc
Involved Pathway
AKR1C1 involved in several pathways and played different roles in them. We selected most pathways AKR1C1 participated on our site, such as Adaptive Immune System,Aldosterone synthesis and secretion,Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1C1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alzheimers disease | APAF1,COX7C,CASP8,FAS,ATP2A3,APOE,GSK3B,NDUFB7,NDUFC1,COX6C |
| Aldosterone synthesis and secretion | GNA11,CALM3,NETO2,SCARB1,CREB3,SLC14A2,CYP21A2,PRKD2,CALM1,CYP21A1 |
| Calcium signaling pathway | ITPKB,PLCD1B,P2RX5,GRIN1A,PPP3CCA,CHRM2A,CALM3,ATP2A2A,PLCE1,ATP2A3 |
| Circadian entrainment | GNAI1,PLCB2,GRIA4,PRKCA,GNG11,KCNJ6,CALM3,PER2,GNG2,GNB4 |
| Cholinergic synapse | PRKACB,CREB3L3,PRKCG,CHRM4,KCNJ2,CHRNA3,PRKCB,PRKCA,CHRNB4,GNGT1 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | STIM1B,ITPR2,IGLC2,SRMS,IGKV1-5,IGHM,AHCYL1,IGKC,PIK3AP1,BLK |
| Adaptive Immune System | CDKN1B,SIGLEC10,FGF20A,ERAP2,LRSAM1,PJA2,DCTN1,SIGLEC7,FRS2,FCGR1B |
| Calcium Regulation in the Cardiac Cell | GJB4,RGS10,ANXA6,ADRB2,CX35.4,GJA10,KCNJ5,CHRM2,GNB5B,GNG13B |
Protein Function
AKR1C1 has several biochemical functions, for example, calcium channel activity,calcium ion binding,inositol 1,3,4,5 tetrakisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1C1 itself. We selected most functions AKR1C1 had, and list some proteins which have the same functions with AKR1C1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| intracellular ligand-gated calcium channel activity | RYR2,ITPR1,TRPA1,ITPR3 |
| inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity | ITPR2,ITPR3,ITPR1 |
| ion channel activity | SCN8AA,NALCN,GRIN3B,ITPR1,P2RX3A,KCNC2,TPCN1,FXYD6L,GRIN2BB,Chrng |
| calcium channel activity | SLC24A4,CACNG2B,PKD2L1,PANX1,CACNA1DA,PSEN1,TRPV2,TRPC2B,CACNG8A,CACNA2D3 |
| inositol hexakisphosphate binding | ITPR3 |
| phosphatidylinositol binding | SNX9B,SNX29,ESYT2,SNX18A,SNX16,SNX9A,PIK3C2B,TNFAIP8L3,MITD1,MTM1 |
| inositol 1,3,4,5 tetrakisphosphate binding | ITPR3,ADAP1,SYT2,ADAP2 |
| calcium ion binding | C2CD4B,RCV1,ATP2C1,CAPN13,CALM3,MMP28,PCDH2AB3,ASPN,CDH3,THBD |
| protein binding | DDAH2,SOX14,NPHS1,RRM2,ZBTB26,ZNF18,GPATCH8,TXNDC12,ZFP36,INO80 |
Interacting Protein
AKR1C1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1C1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1C1.
PTPN3;MAPK3;COMMD8;FN1
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