AKR1C1

  • Official Full Name

    aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)

  • Overview

    This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

  • Synonyms

    AKR1C1;aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1;20-alpha (3-alpha)-hydroxysteroid dehydrogenase);DDH1;aldo-keto reductase family 1 member C1;DD1;DDH;HAKRC;MBAB;2-dihydrobenzene-1;2-diol dehydrogenase;20 alpha (3 alpha) hydroxysteroid dehydrogenase;20 ALPHA HSD;20 alpha hydroxysteroid dehydrogenase;20-alpha-HSD;20-alpha-hydroxysteroid dehydrogenase;20ALPHAHSD;2ALPHAHSD;AK1C1;AK1C1_HUMAN;Aldo keto reductase family 1 member C1;C9;Chlordecone reductase homolog;Chlordecone reductase homolog HAKRC;DD1/DD2;Dihydrodiol dehydrogenase 1;Dihydrodiol dehydrogenase 1/2;dihydrodiol dehydrogenase isoform DD1;H37;HBAB;Hepatic dihydrodiol dehydrogenase;High affinity hepatic bile acid-binding protein;High-affinity hepatic bile acid-binding protein;Indanol dehydrogenase;MGC8954;Trans-1;Trans-1,2 dihydrobenzene 1,2 diol dehydrogenase;Type II 3 alpha hydroxysteroid dehydrogenase;OTTHUMP00000018992;OTTHUMP00000018993;aldo-keto reductase C;20 alp;H-37;2-ALPHA-HSD

Recombinant Proteins

  • Human
  • Cynomolgus
  • Rhesus macaque
  • E.coli
  • Mammalian Cells
  • HEK293
  • In Vitro Cell Free System
  • His
  • Non
  • Avi
  • Fc
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
AKR1C1-2028H Recombinant Human AKR1C1, His-tagged E.coli Human His
AKR1C1-27157TH Recombinant Human AKR1C1, His-tagged E.coli Human His Full L. 1-323 a.a.
AKR1C1-289C Recombinant Cynomolgus AKR1C1 Protein, His-tagged Mammalian Cells Cynomolgus His
AKR1C1-293R Recombinant Rhesus monkey AKR1C1 Protein, His-tagged Mammalian Cells Rhesus macaque His
AKR1C1-48HCL Recombinant Human AKR1C1 cell lysate Human Non
AKR1C1-121R Recombinant Rhesus Macaque AKR1C1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
AKR1C1-121R-B Recombinant Rhesus Macaque AKR1C1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
AKR1C1-1366HF Recombinant Full Length Human AKR1C1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 323 amino acids
AKR1C1-39C Recombinant Cynomolgus Monkey AKR1C1 Protein, His (Fc)-Avi-tagged HEK293 Cynomolgus Avi&Fc&His
AKR1C1-39C-B Recombinant Cynomolgus Monkey AKR1C1 Protein Pre-coupled Magnetic Beads HEK293 Cynomolgus

    Involved Pathway

    AKR1C1 involved in several pathways and played different roles in them. We selected most pathways AKR1C1 participated on our site, such as Adaptive Immune System,Aldosterone synthesis and secretion,Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1C1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Circadian entrainment NOS1AP,GNG11,GUCY1B3,RYR1,PER2,PRKG2,PLCB1,CALM2,GNGT2,KCNJ5
    Calcium signaling pathway ATP2A2A,EDNRB2,PHKG1B,GRIN2D,PRKCB,ADRA1D,CYSLTR2,ATP2B3B,EDNRA,P2RX3B
    Adaptive Immune System ACTR1B,ARF1,ASB2,CD96,LRSAM1,DTX3L,KIF18A,ATG7,CLTC,VPRBP
    Alzheimers disease RYR3,NDUFC2-KCTD14,HSD17B10,APH1C,UQCRC1,APH1B,NDUFA10,GRIN2D,UQCRFS1,NDUFB5
    Antigen activates B Cell Receptor (BCR) leading to generation of second messengers IGLC2,STIM1B,ITPR2,IGHM,BLK,AHCYL1,SRMS,IGKC,IGKV1-5,PIK3AP1
    Calcium Regulation in the Cardiac Cell CX55.5,KCNJ5,RGS7,GNB3B,YWHAQ,CHRM4,KCNB1,RGS14A,CX34.4,ADRB1
    Aldosterone synthesis and secretion CALM4,CAMK4,PRKCE,CREB3L1,LIPE,HSD3B4,CREB5,CAMK1D,PLCB3,ORAI1
    Cholinergic synapse GNAI2,AKT1,GNAO1,KCNJ4,PIK3R3,GNG12,CREB3L3,GNG7,ITPR1,CAMK2D

    Protein Function

    AKR1C1 has several biochemical functions, for example, calcium channel activity,calcium ion binding,inositol 1,3,4,5 tetrakisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1C1 itself. We selected most functions AKR1C1 had, and list some proteins which have the same functions with AKR1C1. You can find most of the proteins on our site.

    Function Related Protein
    intracellular ligand-gated calcium channel activity ITPR3,TRPA1,ITPR1,RYR2
    inositol 1,4,5 trisphosphate binding TRPC7A,TRPC1,TRPC7,RPH3A,TRPC2,TRPC3,TRPC2B,PLCL1,TRPC6A,TRPC5A
    calcium ion binding SYT5,PLCB3,CSN2,MBL2,THBS1,PGS1,PCDHGA2,MMP1,S100A10A,FLG
    protein binding KCND2,TULP3,USH1G,PCGF2,EPRS,ANGPTL4,EHD3,ING2,SGIP1,SKP2
    calcium channel activity GRIN2B,CACNA2D3,CACNG1A,TRPM1,TRPC4B,P2RX1,RYR1B,TRPC2B,TRPC4A,CHRNA9
    inositol 1,3,4,5 tetrakisphosphate binding ADAP1,ADAP2,ITPR3,SYT2
    inositol hexakisphosphate binding ITPR3
    inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity ITPR1,ITPR2,ITPR3
    ion channel activity CLCN6,CLCNK,CATSPER2,P2RX8,KCNC3B,KCNH5A,GRIA2B,KCNC1B,KCNH1B,SCN11A

    Interacting Protein

    AKR1C1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1C1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1C1.

    PTPN3;MAPK3;COMMD8;FN1

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