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Akr1e1

  • Official Full Name

    aldo-keto reductase family 1, member E1

Species Cat.# Product name Source (Host) Tag Protein Length Price
Mouse AKR1E1-1505M Recombinant Mouse AKR1E1 Protein Mammalian Cell His
Mouse AKR1E1-441M Recombinant Mouse AKR1E1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Akr1e1-1584M Recombinant Mouse Akr1e1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse AKR1E1-441M-B Recombinant Mouse AKR1E1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

Akr1e1 involved in several pathways and played different roles in them. We selected most pathways Akr1e1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Akr1e1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

Akr1e1 has several biochemical functions, for example, 1,5-anhydro-D-fructose reductase activity, oxidoreductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Akr1e1 itself. We selected most functions Akr1e1 had, and list some proteins which have the same functions with Akr1e1. You can find most of the proteins on our site.

Function Related Protein
1,5-anhydro-D-fructose reductase activityAKR1E2;AKR1E1
oxidoreductase activityHMGCRB;FDFT1;CYP46A1.2;AOC1;CYP2C39;CYP2P6;ALDH3A2B;CYB561;JMJD1C

Akr1e1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Akr1e1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Akr1e1.

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  • Q&As
  • Reviews

Q&As (14)

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Are there any known genetic mutations or polymorphisms in the AKR1E1 gene? 10/05/2022

There is limited information on specific genetic mutations or polymorphisms in the AKR1E1 gene. However, a study has identified a common single nucleotide polymorphism (SNP) in the AKR1E1 gene that is associated with altered enzyme activity. This SNP results in a missense mutation that changes a single amino acid in the protein sequence, potentially affecting its function. Additionally, alterations or variations in gene expression levels of AKR1E1 have been observed in certain diseases and conditions, suggesting that genetic factors may contribute to its dysregulation.

Are there any known physiological or pathological roles of AKR1E1 protein besides drug metabolism? 03/14/2022

In addition to its involvement in drug metabolism, AKR1E1 has been implicated in the detoxification of lipid-derived aldehydes formed during oxidative stress. It may also play a role in the metabolism of prostaglandins, potentially impacting inflammation and other physiological processes. However, further research is necessary to fully understand the extent of AKR1E1's involvement in these pathways.

Is AKR1E1 protein regulated by any factors? 03/13/2022

Yes, AKR1E1 expression can be regulated by several factors. Studies suggest that transcriptional regulation by nuclear receptors, such as the estrogen receptor alpha (ERα), can influence AKR1E1 expression levels. Additionally, epigenetic modifications, such as DNA methylation, can also impact AKR1E1 gene expression. Further research is needed to fully understand the regulatory mechanisms of AKR1E1.

Are there any inhibitors or activators of AKR1E1 protein? 02/12/2022

Currently, there are no well-established specific inhibitors or activators for AKR1E1 protein. However, some studies have identified compounds that can modulate the activity of AKR1E1, including the natural product resveratrol and the potential AKR inhibitor EP-475. Further research is needed to identify more specific regulators of AKR1E1.

Can AKR1E1 protein be targeted for therapeutic purposes? 01/10/2022

The potential for targeting AKR1E1 protein for therapeutic purposes has not been extensively explored. However, as AKR1E1 has been implicated in various diseases and its dysregulation has been observed in cancers, it may represent a potential target for therapeutic interventions. Modulating AKR1E1 activity or expression could potentially impact the metabolism of endogenous compounds or drug metabolism. Further research is needed to understand its precise role in different diseases and develop specific therapeutic strategies targeting AKR1E1.

Is AKR1E1 protein involved in any other biological pathways? 01/01/2020

Apart from its role in tamoxifen metabolism, AKR1E1 is also implicated in other pathways, such as the biosynthesis of prostaglandins, metabolism of steroids, and detoxification of aldehydes. Its broad substrate specificity suggests potential involvement in various physiological processes, but additional research is required to fully elucidate its functions in these pathways.

Is AKR1E1 protein involved in any metabolic pathways? 12/02/2019

AKR1E1 protein is involved in multiple metabolic pathways, including drug metabolism and lipid metabolism. It functions as an NADPH-dependent reductase, catalyzing the reduction of aldehydes and ketones to their corresponding alcohols. This activity is important in the detoxification of various endogenous and exogenous compounds. AKR1E1 is also believed to play a role in the metabolism of lipid-derived aldehydes and prostaglandins, although the exact mechanisms and pathways are still being investigated.

Are there any diseases associated with AKR1E1 protein dysfunction? 10/10/2019

Currently, there are no known diseases directly associated with AKR1E1 protein dysfunction. However, alterations in AKR1E1 activity or expression may impact the metabolism and effectiveness of tamoxifen, potentially affecting breast cancer treatment outcomes. Further research is necessary to explore the full scope of AKR1E1's role in health and disease.

Are there any diseases or conditions associated with dysregulation of AKR1E1 protein? 09/07/2019

Currently, there is limited information on diseases or conditions directly associated with dysregulation of AKR1E1 protein. However, alterations in AKR1E1 expression or activity have been observed in certain cancers. For example, AKR1E1 has been found to be upregulated in hepatocellular carcinoma and pancreatic cancer, suggesting a potential role in tumor development and progression. Further research is needed to fully understand the implications of AKR1E1 dysregulation in these diseases.

Does AKR1E1 protein have any cellular localization? 06/02/2018

AKR1E1 is predominantly localized in the cytoplasm, although there is some evidence of nuclear localization in certain cell types. The exact cellular localization of AKR1E1 may vary depending on cell type and context.

Are there any known AKR1E1 protein polymorphisms or variants? 05/26/2018

Limited information is available regarding AKR1E1 protein polymorphisms or variants. However, genetic variations in the AKR1E1 gene may potentially influence the efficacy of tamoxifen therapy in breast cancer patients. Further investigation is necessary to determine the specific impact of AKR1E1 genetic variants on drug metabolism and response.

Are there any other proteins that interact with AKR1E1? 09/06/2016

Currently, there is limited information about specific protein-protein interactions involving AKR1E1. However, it is known that AKR1E1 can interact with other enzymes involved in drug metabolism, such as cytochrome P450 enzymes. Future studies may uncover additional protein interactions involving AKR1E1.

How is AKR1E1 gene expression regulated? 06/12/2016

The regulation of AKR1E1 gene expression is not well-characterized. However, various transcription factors and signaling pathways may influence its expression. For example, studies have shown that AKR1E1 expression can be induced by nuclear factor erythroid 2-related factor 2 (Nrf2), a key regulator of oxidative stress response. Other factors, such as hormones and growth factors, may also play a role in AKR1E1 gene regulation, but more research is needed to fully understand the mechanisms involved.

What other proteins interact with AKR1E1 protein? 04/23/2016

The protein-protein interactions of AKR1E1 are not extensively characterized. However, some studies have reported potential interactions with other proteins. For example, AKR1E1 has been found to interact with aldose reductase, an enzyme involved in glucose metabolism. Additionally, AKR1E1 has been shown to interact with thioredoxin, a protein involved in redox signaling and cellular defense mechanisms. These interactions suggest potential roles for AKR1E1 in glucose metabolism and oxidative stress response, but further investigation is needed to confirm and understand the functional significance of these interactions.

Customer Reviews (4)

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Reviews
02/13/2023

    Incorporating this protein into scientific investigations undoubtedly enhances the reliability and effectiveness of research endeavors.

    05/29/2020

      In addition to the remarkable protein quality, the manufacturer provides excellent technical support, proving to be a valuable resource when troubleshooting experimental challenges.

      11/01/2016

        Whether investigating metabolic pathways, studying enzymatic activity, or exploring drug targets, this protein offers versatility and reliability, allowing for accurate and meaningful data collection.

        06/08/2016

          This level of support instills trust and confidence in the product, facilitating smooth and successful experimentation.

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