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  • Official Full Name

    aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase)

Species Cat.# Product name Source (Host) Tag Protein Length Price
Mouse AKR7A5-1506M Recombinant Mouse AKR7A5 Protein Mammalian Cell His
Mouse AKR7A5-442M-B Recombinant Mouse AKR7A5 Protein Pre-coupled Magnetic Beads HEK293
Mouse AKR7A5-442M Recombinant Mouse AKR7A5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

Akr7a5 involved in several pathways and played different roles in them. We selected most pathways Akr7a5 participated on our site, such as Metabolism of xenobiotics by cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with Akr7a5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Metabolism of xenobiotics by cytochrome PAKR7A2;UGT1A6A;UGT1A6;CBR2;ALDH3A1;DHDH;ALDH3B1;MGST1.2;MGST1

Akr7a5 has several biochemical functions, for example, alditol:NADP+ 1-oxidoreductase activity, oxidoreductase activity, phenanthrene-9,10-epoxide hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Akr7a5 itself. We selected most functions Akr7a5 had, and list some proteins which have the same functions with Akr7a5. You can find most of the proteins on our site.

Function Related Protein
alditol:NADP+ 1-oxidoreductase activityAkr1b3;AKR7A5;AKR1B8;AKR1C2;ADH4;AKR1A1;AKR7A2;AKR1C21;AKR1C3
oxidoreductase activityCYP2D6;CYP2D26;SPRB;DHRS13;HADHAA;IYD;CRYM;RTN4IP1;PCYOX1L
phenanthrene-9,10-epoxide hydrolase activityAKR7A2;AKR7A5;PRKRA

Akr7a5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Akr7a5 here. Most of them are supplied by our site. Hope this information will be useful for your research of Akr7a5.

Ywhae; Hsd3b4; Pgls

  • Q&As
  • Reviews

Q&As (23)

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Where is AKR7A5 primarily expressed? 10/09/2022

AKR7A5 is predominantly expressed in the liver, although lower levels of expression have been detected in other tissues such as the kidney, lung, and small intestine.

What diseases or disorders are associated with AKR7A5 mutations? 05/08/2022

To date, there are no known diseases or disorders directly associated with AKR7A5 mutations. However, given its potential involvement in detoxification processes, it is possible that mutations in AKR7A5 could lead to altered metabolism and potentially contribute to the development or progression of certain diseases. More research is required to clarify this association.

Are there any known regulators of AKR7A5 expression? 02/27/2022

Several factors and signaling pathways have been implicated in the regulation of AKR7A5 expression. For instance, the nuclear factor erythroid 2-related factor 2 (NRF2) pathway plays a crucial role in upregulating AKR7A5 expression in response to oxidative stress. Activation of this pathway leads to increased transcription of AKR7A5. Additionally, certain drugs and chemicals, such as tBHQ and sulforaphane, can also induce AKR7A5 expression through NRF2 activation. However, more research is needed to fully elucidate the regulatory mechanisms governing AKR7A5 expression.

Are there any genetic variations or mutations in AKR7A5 associated with diseases? 10/24/2021

There have been limited studies investigating genetic variations or mutations specifically in AKR7A5 and their association with diseases. However, some genetic variants in the AKR7A5 gene have been identified in certain populations. For example, a single nucleotide polymorphism (SNP) known as rs7199848 has been found to be associated with variations in AKR7A5 expression levels. This SNP has also been linked to increased susceptibility to lung cancer and chronic obstructive pulmonary disease (COPD) in some populations. However, more research is needed to establish the precise impact of AKR7A5 genetic variations on disease susceptibility and progression.

Is AKR7A5 associated with any genetic disorders? 01/28/2021

There is currently no evidence to suggest a direct association between AKR7A5 and any specific genetic disorders. As mentioned earlier, mutations in AKR7A5 have not been linked to any known diseases or disorders so far. However, further research may uncover its potential involvement in certain genetic conditions or disease susceptibility.

Are there any known inhibitors or drugs that target AKR7A5? 10/14/2020

There is limited information available regarding specific inhibitors or drugs that target AKR7A5. Further research is needed to explore the potential of targeting AKR7A5 for therapeutic interventions.

Is AKR7A5 involved in cancer development or progression? 07/16/2020

The role of AKR7A5 in cancer development or progression is not well-established. Some studies have suggested its potential involvement in drug resistance and the detoxification of carcinogenic compounds, but further research is needed to determine its precise role in cancer biology.

Can AKR7A5 influence the response to chemotherapy? 04/06/2020

There is limited information on the direct influence of AKR7A5 on the response to chemotherapy. However, some studies have investigated the relationship between AKR7A5 expression and chemotherapy outcomes in cancer patients. For example, higher levels of AKR7A5 expression have been associated with resistance to certain chemotherapy drugs, such as cisplatin, in ovarian cancer patients. These findings suggest that AKR7A5 may have a potential impact on the response to chemotherapy, but more research is needed to confirm and understand the underlying mechanisms.

Does AKR7A5 have any effect on oxidative stress? 01/04/2020

AKR7A5 has been proposed to play a role in protecting cells against oxidative stress. By metabolizing reactive carbonyl compounds and quenching reactive oxygen species (ROS), AKR7A5 may help maintain cellular redox homeostasis and prevent oxidative damage. Studies have suggested that AKR7A5 expression can be induced by oxidative stress through NRF2 activation. However, the precise mechanisms by which AKR7A5 contributes to oxidative stress defense require further investigation.

How is AKR7A5 related to cancer? 10/26/2019

There is limited information regarding the direct involvement of AKR7A5 in cancer. However, some studies have observed altered expression of AKR7A5 in certain types of cancer, suggesting a possible association. For example, reduced expression of AKR7A5 has been observed in colorectal cancer and hepatocellular carcinoma. The exact role of AKR7A5 in cancer development and progression is still not well understood, and further research is required to determine its significance in the context of different types of cancer.

Are there any known substrates of AKR7A5? 04/07/2019

AKR7A5 has been shown to have enzymatic activity towards a range of substrates, including aldehydes and ketones. Some specific substrates that have been identified for AKR7A5 include 4-hydroxynonenal (4-HNE), a highly reactive lipid peroxidation product, and o-quinones, which are toxic intermediates involved in the metabolism of various compounds.

Can AKR7A5 be targeted for therapeutic purposes? 02/21/2019

The therapeutic targeting of AKR7A5 is currently an area of ongoing research. Its involvement in detoxification processes and potential roles in drug metabolism and oxidative stress response make it an interesting target for therapeutic interventions. However, more studies are needed to fully understand its functions and determine the feasibility of targeting AKR7A5 for therapeutic purposes.

Are there any known inhibitors of AKR7A5? 12/20/2018

Efforts to identify specific inhibitors of AKR7A5 have been limited and there are currently no widely recognized inhibitors available. Further research is needed to discover and develop potential inhibitors that can selectively target AKR7A5, which could be valuable for elucidating its functions and exploring therapeutic applications.

Are there any known alternative splicing variants of AKR7A5? 12/18/2018

To date, there is limited information regarding alternative splicing variants of AKR7A5. However, studies have suggested the presence of alternative isoforms in different tissues and cell types. Further investigation is required to characterize these isoforms and determine their functional significance.

Is AKR7A5 involved in drug metabolism? 10/29/2018

AKR7A5 is thought to be involved in drug metabolism due to its role in detoxification processes in the body. It has been reported to metabolize certain drugs, such as daunorubicin, which is used in cancer treatment. Additionally, studies have suggested that AKR7A5 may play a role in the metabolism of other drugs, including anti-inflammatory drugs and antibiotics. However, the extent of AKR7A5's involvement in drug metabolism and its clinical implications require further investigation.

How is AKR7A5 involved in detoxification processes? 10/26/2018

AKR7A5 plays a crucial role in detoxification processes by catalyzing the reduction of various toxic compounds, including aldehydes and ketones. It helps convert these harmful chemicals into less reactive or more easily excreted forms, thus aiding in the elimination of toxins from the body. This detoxification activity of AKR7A5 contributes to maintaining cellular homeostasis and preventing molecular damage.

Can AKR7A5 metabolize drugs? 08/03/2018

The drug-metabolizing capabilities of AKR7A5 have not been extensively studied. However, some studies have suggested that AKR7A5 may be involved in the metabolism and detoxification of certain drugs. Further research is required to fully understand its drug-metabolizing potential.

Can AKR7A5 be targeted for therapeutic purposes? 04/11/2018

As AKR7A5's function and roles in cellular processes are not fully understood, it is not currently targeted for therapeutic interventions. However, future studies may shed more light on its potential as a therapeutic target for specific diseases or disorders.

What are the physiological substrates of AKR7A5? 04/09/2017

In addition to its detoxification activities, AKR7A5 has been implicated in the metabolism of endogenous compounds. Some known physiological substrates of AKR7A5 include prostaglandin D2 and its metabolite 9α,11β-prostaglandin F2α. These substrates suggest potential roles for AKR7A5 in the regulation of inflammation and other biological processes.

Does AKR7A5 play a role in oxidative stress response? 03/11/2017

AKR7A5 has been implicated in the cellular response to oxidative stress. It has been shown to be upregulated in response to oxidative stress inducers, suggesting its potential role in detoxifying reactive oxygen species and reactive aldehydes generated during oxidative stress. This suggests that AKR7A5 may contribute to the cellular defense against oxidative damage.

Is AKR7A5 expressed in specific tissues or cell types? 04/27/2016

AKR7A5 is widely expressed in various tissues and cell types throughout the body. Studies have detected its expression in the liver, kidney, lung, brain, colon, and skin, among others. However, the exact expression pattern and level of AKR7A5 may vary in different tissues, suggesting potential tissue-specific functions.

How is AKR7A5 regulated? 04/11/2016

The regulatory mechanisms of AKR7A5 expression and activity are not well understood. However, studies have suggested that its expression may be influenced by various factors, including nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor involved in cellular stress response pathways. It has also been shown that AKR7A5 expression can be induced by certain compounds, such as polycyclic aromatic hydrocarbons and oxidative stress inducers.

Is AKR7A5 a potential biomarker for any diseases? 01/18/2016

At present, there is no established biomarker status for AKR7A5 in any diseases or conditions. However, given its potential involvement in detoxification processes and cellular stress response, future studies may evaluate AKR7A5 as a potential biomarker for certain diseases or physiological states.

Customer Reviews (4)

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    Its consistent performance and reproducibility have been praised by scientists who have employed it in their studies, with many reporting outstanding results and a high level of satisfaction.


      This strong track record of excellence further attests to the AKR7A5 protein's capability to meet the rigorous demands of research projects.


        Its exceptional characteristics, coupled with the manufacturer's commitment to customer satisfaction, ensure that I can pursue my scientific investigations with confidence and success.


          Its high quality, reliability, and exceptional performance make it an excellent choice for a wide range of experimental applications.

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