alt a 1
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Alternaria tenuis | Alt a 1-29A | Recombinant Alternaria tenuis allergen Alt a 1 Protein | E.coli |
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Q&As (10)
Ask a questionAlt a 1 can induce airway epithelial cell responses, including increased production of cytokines, chemokines, and activation of pattern recognition receptors, triggering immune responses.
Alt a 1 exhibits enzymatic activity as a protease, contributing to its allergenicity and its potential to disrupt epithelial barriers or cleave immune-related proteins.
Alt a 1 interacts with IgE antibodies, triggering the activation of immune cells, including mast cells and basophils, which release inflammatory mediators upon binding to Alt a 1.
The three-dimensional structure of Alt a 1 reveals a compact fold with distinct regions that contribute to its allergenic properties, such as its IgE-binding sites or regions involved in protein-protein interactions.
Epitope mapping studies have identified specific regions of Alt a 1 that are recognized by IgE antibodies, providing insights into the molecular basis of allergic responses.
Immunotherapy approaches, such as allergen-specific immunotherapy or peptide-based vaccines targeting Alt a 1, hold promise for desensitizing allergic individuals and reducing allergic symptoms by inducing tolerance or modifying immune responses to Alt a 1.
Genetic variations or polymorphisms in Alt a 1 may influence the susceptibility to allergic sensitization or the severity of allergic reactions, potentially modulating disease outcomes.
Alt a 1 exhibits moderate stability under physiological conditions, with some susceptibility to denaturation or aggregation under certain environmental or biochemical conditions.
Environmental factors, such as temperature, humidity, and exposure to fungal spores, can influence the expression and release of Alt a 1, potentially enhancing allergic sensitization.
Alt a 1 activates mast cells and basophils, leading to the release of histamine, leukotrienes, and cytokines, which contribute to the characteristic symptoms of allergic reactions.
Customer Reviews (3)
Write a reviewLong-lasting and reliable assay performance.
Highly sensitive detection of protein modifications.
Comprehensive characterization of protein structure and function.
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