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  • Official Full Name

    Atrial natriuretic peptide

  • Overview

    Atrial natriuretic peptide (ANP), atrial natriuretic factor (ANF), atrial natriuretic hormone (ANH), or atriopeptin is a powerful vasodilator, and a protein (polypeptide) hormone secreted by heart muscle cells.[1][2] It is involved in the homeostatic control of body water, sodium, potassium and fat (adipose tissue). It is released by muscle cells in the upper chambers (atria) of the heart (atrial myocytes) in response to high blood pressure. ANP acts to reduce the water, sodium and adipose loads on the circulatory system, thereby reducing blood pressure.
  • Synonyms

    ANF; ANP; ANH, Atrial natriuretic factor; Atrial natriuretic peptide; CDD ANF; CDD-ANF; CDP; Natriuretic Peptide Precursor A; NPPA; PND; Prepronatriodilatin; Pronatriodilatin; Pro-ANP; Pro-Atrial Natriuretic Peptide (a.a. 1-30); Atrial natriuretic peptide;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ANP-3768H Recombinant Human ANP, His-tagged, GST-tagged E.coli His/GST 151
Rabbit ANP-3343R Recombinant Rabbit ANP protein, His-SUMO-tagged E.coli His-SUMO Ser124~Tyr151
Rabbit ANP-3344R Recombinant Rabbit ANP protein, His-tagged E.coli His Ser124~Tyr151

ANP involved in several pathways and played different roles in them. We selected most pathways ANP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ANP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ANP has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ANP itself. We selected most functions ANP had, and list some proteins which have the same functions with ANP. You can find most of the proteins on our site.

Function Related Protein

ANP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANP here. Most of them are supplied by our site. Hope this information will be useful for your research of ANP.

  • Q&As
  • Reviews

Q&As (8)

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Are there any genetic variations or mutations associated with ANP protein? 02/17/2022

Yes, certain genetic variations in the ANP gene have been identified. These variations can affect the expression or function of ANP protein and have been implicated in cardiovascular diseases like hypertension and heart failure. However, more studies are needed to fully understand the impact of these genetic variations on ANP physiology.

How is ANP protein cleared from the body? 11/28/2020

ANP protein is primarily cleared by the kidneys. It is filtered through the glomeruli and then partially reabsorbed in the proximal tubules. The remaining ANP is excreted in the urine.

How is ANP protein synthesized and secreted? 11/15/2020

ANP protein is synthesized and secreted primarily by the atrial myocytes in the heart. The synthesis process involves the translation of the ANP mRNA, which is transcribed from the ANP gene. The pre-proANP molecule is then produced, which undergoes post-translational modifications, including cleavage of the signal peptide to form pro-ANP. Pro-ANP is further processed in secretory granules within the atrial myocytes, resulting in the formation of the mature ANP peptide.

How is ANP protein released? 09/16/2020

ANP protein is released in response to increased pressure and stretching of the heart's atria, usually caused by excess blood volume. When the heart senses this stretching, it secretes ANP into the bloodstream. ANP production is regulated by various factors like atrial filling, sympathetic nervous system activity, and hormonal influences.

Can ANP levels be used as a diagnostic marker? 05/17/2019

Yes, ANP levels can be used as a diagnostic marker in certain clinical situations. Elevated levels of ANP may indicate conditions such as heart failure, atrial fibrillation, atrial enlargement, or renal dysfunction. Conversely, low levels of ANP can be seen in conditions associated with low blood volume, such as dehydration or hypovolemia.

Are there any clinical implications of ANP protein? 09/04/2017

Yes, ANP protein is clinically relevant. It is often measured as a biomarker in conditions like heart failure, where ANP levels are elevated due to increased cardiac strain. ANP tests can assist in diagnosing and monitoring heart-related disorders. Additionally, ANP-based medications (such as Nesiritide) have been used in managing acute decompensated heart failure.

Is ANP protein involved in blood pressure regulation? 01/07/2017

Yes, ANP protein plays a crucial role in blood pressure regulation. By promoting sodium excretion, ANP reduces blood volume, which in turn decreases blood pressure. ANP also acts as a vasodilator, relaxing and widening blood vessels, further contributing to the lowering of blood pressure.

What factors influence ANP protein secretion? 02/22/2016

ANP protein secretion is primarily influenced by the stretching of the atria. Increased atrial pressure, caused by factors like volume overload or hypertension, stimulates the release of ANP. Other factors that can affect ANP secretion include sympathetic nervous system activity, atrial distention, atrial stretch receptors, and hormonal influences.

Customer Reviews (4)

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    The ANP protein is of exceptional quality, making it an ideal choice to meet my experimental needs.


      The ANP protein is highly recommended for researchers conducting protein studies, especially in Western blotting (WB) experiments.


        This protein demonstrates great performance in WB assays, providing accurate and reliable results that are crucial for protein analysis.


          the ANP protein has proven to be an invaluable tool in protein electron microscopy (EM) structure analysis.

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