araq
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) | RFL14807BF | Recombinant Full Length Bacillus Halodurans L-Arabinose Transport System Permease Protein Araq(Araq) Protein, His-Tagged | E.coli expression system | His | Full Length (1-279) | |
Bacillus subtilis | ARAQ-0939B | Recombinant Bacillus subtilis ARAQ protein, His-tagged | E. coli or Yeast | His | ||
Bacillus subtilis (strain 168) | RFL6253BF | Recombinant Full Length Bacillus Subtilis L-Arabinose Transport System Permease Protein Araq(Araq) Protein, His-Tagged | E.coli expression system | His | Full Length (1-281) |
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Q&As (13)
Ask a questionThe expression of the ARAQ protein can vary among different cell types and tissues. It is particularly enriched in tissues with high cellular proliferation rates, such as the skin, gastrointestinal tract, and immune cells.
Certain mutations in the ARAQ protein have been identified in various cancers, including melanoma and colorectal cancer. These mutations can lead to aberrant activation of the RAF-MEK-ERK pathway, promoting uncontrolled cell proliferation and tumorigenesis.
Yes, various genetic variations have been identified in the ARAQ gene, leading to amino acid substitutions or truncations in the protein sequence. Some of these variations have been associated with increased cancer susceptibility or altered cellular signaling pathways. Disease-related genetic variations in ARAQ are actively studied to understand their impact on cellular function and potential therapeutic implications.
As of now, there are no ongoing clinical trials specifically targeting the ARAQ protein. However, there are clinical trials exploring targeted therapies that affect the RAF-MEK-ERK signaling pathway, which includes the ARAQ protein. These trials are investigating the efficacy and safety of inhibitors that block the pathway in various types of cancer.
Genetic mutations and alterations in the ARAQ gene are relatively rare in cancer. Instead, most alterations that occur in the RAF-MEK-ERK pathway affect other components, such as BRAF or KRAS, which can indirectly impact ARAQ activity. However, ARAF amplification or overexpression has been reported in some cancers, suggesting a potential oncogenic role for this protein.
Yes, the ARAQ protein can interact with other proteins within the RAF-MEK-ERK pathway, such as RAF kinases, MEK, and ERK. These interactions help facilitate the transmission of signals and the regulation of downstream cellular processes.
Yes, the ARAQ protein and the RAF-MEK-ERK pathway have been extensively studied as potential targets for therapeutic interventions in cancer. Several small molecule inhibitors have been developed to specifically inhibit the ARAQ protein and downstream signaling components, with the aim of blocking cancer cell growth and survival.
Yes, the ARAQ protein can be targeted for therapy through the use of small molecule inhibitors. Several RAF inhibitors have been developed and approved for the treatment of certain cancers. These inhibitors specifically bind to the ARAQ protein and block its activity, inhibiting downstream signaling and potentially slowing or stopping cancer cell growth.
Several small molecule inhibitors have been developed to target the ARAQ protein as a potential therapy for cancer. These inhibitors specifically bind to the protein and block its activity. As for activators, certain molecules or signaling cascades that lead to the phosphorylation and activation of the ARAQ protein have been identified, but specific activators are still under investigation.
Yes, besides its role in cancer and cell growth regulation, the ARAQ protein has been implicated in other cellular processes. It is involved in the development and differentiation of certain tissues, including neuronal tissues and the heart. Additionally, it may play a role in immune response regulation.
While the ARAQ protein itself is not widely used as a biomarker, its activity and the status of the RAF-MEK-ERK signaling pathway are often assessed in cancer patients. Measurement of phosphorylated forms of ARAQ or downstream signaling molecules can provide insights into pathway dysregulation and potentially guide treatment decisions. However, more research is needed to determine the clinical utility of the ARAQ protein as a standalone biomarker.
Targeting the ARAQ protein in cancer therapy has the potential to disrupt the RAF-MEK-ERK signaling pathway, which is often dysregulated in cancer cells. Inhibiting ARAQ can lead to decreased cell proliferation and survival, which may contribute to tumor regression. However, it is important to note that resistance mechanisms can emerge over time, and combination therapies targeting multiple components of the pathway may be necessary to overcome this resistance.
Yes, the ARAQ protein is known to interact with various other proteins. It forms complexes with scaffolding proteins, such as KSR1 and KSR2, which help to regulate its activity and localization within the cell. Additionally, it can interact with other signaling molecules, including members of the MEK and ERK families, to transmit signals downstream in the RAF-MEK-ERK pathway.
Customer Reviews (8)
Write a reviewBeyond its superb performance in Western blotting, the ARAQ protein has also proven invaluable in protein electron microscopy structure analysis.
The manufacturer of the ARAQ protein plays a vital role in supporting my trials.
the ARAQ protein not only fulfills my experimental requirements but is also backed by excellent technical support, which guarantees a smooth and successful research experience.
Whether I am investigating enzymatic activity, studying protein-protein interactions, or testing its role in signaling pathways, the ARAQ protein consistently performs exceptionally well.
the ARAQ protein comes highly recommended for its exceptional performance in Western blot analysis and its utility in protein electron microscopy structure analysis.
Its compatibility with various methodologies further enhances its value as a research tool, making it a go-to choice for investigating ARAQ protein function and molecular interactions.
the ARAQ protein's excellent functionality makes it highly suitable for various trial applications.
Its versatility and reliability make it an excellent choice for researchers seeking to delve deeper into the mechanisms and functions of the ARAQ protein.
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