ARMC5

  • Official Full Name

    armadillo repeat containing 5

  • Synonyms

    ARMC5;armadillo repeat containing 5;25781;ENSG00000140691;16p11.2;FLJ00019, FLJ13063;armadillo repeat-containing protein 5;armadillo repeat-containing protein 5;
    • Type:
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E. coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • Strep
    • No tag
    Species Cat.# Product name Source (Host) Tag Price
    Human ARMC5-790H Recombinant Human ARMC5 protein, GST-tagged E. coli GST
    Human ARMC5-0584H Recombinant Human ARMC5 Protein (A2-A935), Tag Free Insect Cell No tag
    Human ARMC5-0585H Recombinant Human ARMC5 Protein (A2-A935), His/Strep tagged Insect Cell His/Strep
    Mouse ARMC5-1950M Recombinant Mouse ARMC5 Protein Mammalian Cell His
    Mouse ARMC5-736M Recombinant Mouse ARMC5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse ARMC5-736M-B Recombinant Mouse ARMC5 Protein Pre-coupled Magnetic Beads HEK293
    Rat ARMC5-790R Recombinant Rat ARMC5 Protein Mammalian Cell His
    Rat ARMC5-446R Recombinant Rat ARMC5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat ARMC5-446R-B Recombinant Rat ARMC5 Protein Pre-coupled Magnetic Beads HEK293
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • ARMC5 Related Articles

    ARMC5 involved in several pathways and played different roles in them. We selected most pathways ARMC5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ARMC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    ARMC5 has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by ARMC5 itself. We selected most functions ARMC5 had, and list some proteins which have the same functions with ARMC5. You can find most of the proteins on our site.

    Function Related Protein
    molecular_functionNOMO1;RMI2;FBXO24;ZNF24;INO80DB;DESI1B;FLOT2B;TMEM252;HMCES

    ARMC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARMC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARMC5.

    Duan, K; Hernandez, KG; et al. Clinicopathological correlates of adrenal Cushing's syndrome. JOURNAL OF CLINICAL PATHOLOGY 68:175-186(2015).
    Berthon, A; Stratakis, CA; et al. From beta-Catenin to ARM-Repeat Proteins in Adrenocortical Disorders. HORMONE AND METABOLIC RESEARCH 46:889-896(2014).
    • Q&As
    • Reviews

    Q&As (29)

    Ask a question
    Can ARMC5 mutations be inherited? 08/26/2022

    Yes, ARMC5 mutations can be inherited in an autosomal dominant pattern, meaning that individuals with a mutated copy of ARMC5 have a 50% chance of passing the mutation on to their offspring.

    Is ARMC5 expression regulated by any external factors or hormones? 04/06/2022

    The regulation of ARMC5 expression is not well understood. However, studies suggest that ACTH (adrenocorticotropic hormone), which stimulates cortisol production, may influence ARMC5 expression levels.

    Are there any other diseases or conditions associated with ARMC5 mutations? 03/15/2022

    ARMC5 mutations are primarily associated with PBMAH. However, recent studies have suggested potential links between ARMC5 mutations and other adrenal disorders, such as adrenal adenomas and hyperplasia. Further research is needed to establish these associations conclusively.

    Can individuals with ARMC5-related disorders lead a normal life? 02/05/2022

    With appropriate management and treatment, individuals with ARMC5-related disorders can lead fulfilling lives. However, the specific impact on daily life may vary depending on the severity and progression of the disorder.

    Are there any clinical trials currently investigating potential treatments for ARMC5-related disorders? 07/13/2021

    As of now, there are no known clinical trials specifically focused on investigating potential treatments for ARMC5-related disorders. However, ongoing research may uncover new therapeutic approaches in the future.

    Can ARMC5 protein be used as a diagnostic marker for PBMAH? 05/18/2021

    Yes, ARMC5 mutations or loss of expression can be used as diagnostic markers for PBMAH. Genetic testing for ARMC5 mutations can help confirm the diagnosis of this rare adrenal disorder.

    Are there any ongoing research efforts focused on ARMC5 and its related disorders? 04/10/2021

    Yes, ongoing research is focused on understanding the cellular mechanisms of ARMC5, exploring potential therapeutic targets, and improving diagnostic methods for ARMC5-related disorders.

    What happens when ARMC5 protein is mutated or dysfunctional? 10/04/2020

    Mutations or dysfunction in ARMC5 protein can lead to a rare genetic disorder called primary bilateral macronodular adrenal hyperplasia (PBMAH). This condition results in the formation of abnormal nodules in the adrenal glands, leading to overproduction of cortisol and potentially causing Cushing's syndrome.

    Can ARMC5 mutations be detected through genetic testing in adults without symptoms? 09/10/2020

    Yes, genetic testing can detect ARMC5 mutations in adults without symptoms, particularly those with a known family history of ARMC5-related disorders. Testing can help identify carriers and individuals at risk of developing the disorder in the future.

    Are there any known interacting partners of ARMC5 protein? 07/30/2020

    Yes, ARMC5 has been found to interact with several other proteins, including MEN1 (Multiple Endocrine Neoplasia Type 1), a tumor suppressor gene associated with a variety of endocrine tumors.

    Are there any targeted therapies or medications available for treating ARMC5-related disorders? 12/07/2019

    Currently, there are no targeted therapies or specific medications available for treating ARMC5-related disorders. Management typically involves surgery to remove tumors or nodules causing symptoms and may also involve hormone replacement therapy to normalize hormone levels.

    Can ARMC5 mutations be detected through genetic testing in individuals without symptoms? 09/24/2019

    Yes, genetic testing can detect ARMC5 mutations in individuals without symptoms, particularly those with a known family history of ARMC5-related disorders. This testing can help identify carriers and at-risk individuals.

    Are there any other known functions of ARMC5 protein? 04/07/2019

    Besides its role in cortisol regulation, ARMC5 protein may have additional functions that are yet to be fully understood. Research suggests its involvement in cell cycle regulation and potentially in DNA repair processes.

    Can ARMC5 mutations be detected through newborn screening? 01/18/2019

    Currently, ARMC5 mutations are not part of routine newborn screening programs. However, if there is a known family history of ARMC5-related disorders, genetic testing can be performed on newborns to determine if they have inherited the mutation.

    Are there any known therapeutic interventions targeting ARMC5 for PBMAH? 12/31/2018

    Currently, there are no specific therapeutic interventions targeting ARMC5 protein for PBMAH. Treatment options for PBMAH typically involve surgical removal of the affected adrenal glands or pharmacological management of cortisol levels.

    Can ARMC5-related disorders affect both children and adults? 10/01/2018

    Yes, ARMC5-related disorders can affect both children and adults. Manifestation of symptoms can occur at any age depending on the specific disorder and the presence of tumors or nodules in the endocrine glands.

    How common are ARMC5-related disorders? 09/22/2018

    ARMC5-related disorders are considered rare. The exact prevalence is not well known, but they are thought to be quite rare, with only a small number of reported cases in medical literature.

    Are there any known environmental factors that can contribute to ARMC5-related disorders? 09/19/2018

    While the exact causes of ARMC5-related disorders are not completely understood, there is no strong evidence suggesting specific environmental factors that contribute to the development of these disorders. The primary cause is believed to be genetic mutations.

    Are there any known risk factors for developing ARMC5-related disorders? 09/08/2018

    The primary risk factor for developing ARMC5-related disorders is inheriting a mutation in the ARMC5 gene. It is usually inherited in an autosomal dominant manner, meaning that individuals who have one affected parent have a 50% chance of inheriting the mutation.

    What are the long-term complications or risks associated with ARMC5-related disorders? 07/12/2018

    Some long-term complications or risks associated with ARMC5-related disorders include the development of adrenal insufficiency after tumor removal, recurrence of tumors, and the potential for other endocrine gland abnormalities due to the involvement of ARMC5 in multiple endocrine tissues.

    Are there any specific guidelines for surveillance or screening of ARMC5-related disorders? 05/07/2018

    Currently, there are no specific guidelines for surveillance or screening for ARMC5-related disorders. However, individuals with a known family history may benefit from regular medical check-ups and screening for endocrine abnormalities.

    Are there any animal models available for studying ARMC5 function? 04/30/2018

    Yes, researchers have developed mouse models with ARMC5 gene knockout, which helps in studying its role in adrenal gland development and cortisol regulation.

    Can ARMC5-related disorders be cured? 02/03/2018

    At present, there is no cure for ARMC5-related disorders. Treatment mainly focuses on managing symptoms and preventing complications through surgical interventions and hormone replacement therapy.

    What are the common symptoms of PBMAH? 02/01/2018

    Common symptoms of PBMAH include weight gain, abdominal obesity, high blood pressure, easy bruising, muscle weakness, fatigue, and menstrual irregularities in women.

    Are there support groups or resources available for individuals with ARMC5-related disorders? 09/02/2017

    Yes, there are support groups and organizations that provide resources, information, and support for individuals and families affected by ARMC5-related disorders. Examples include the Pituitary Network Association and the MAGIC Foundation.

    How do ARMC5 mutations contribute to the development of PBMAH? 03/21/2017

    Mutations in ARMC5 disrupt its tumor suppressor activity, leading to the formation of abnormal nodules in the adrenal glands. These nodules secrete excess cortisol, resulting in the development of PBMAH.

    How is ARMC5 protein involved in cortisol regulation? 09/06/2016

    ARMC5 protein acts as a tumor suppressor and regulates adrenal steroidogenesis by inhibiting the production of cortisol. Loss of ARMC5 function can disrupt this control mechanism, leading to excessive cortisol production.

    Can lifestyle modifications help manage symptoms of PBMAH? 07/26/2016

    While lifestyle modifications alone may not be sufficient to manage PBMAH, adopting a healthy lifestyle can help improve overall health and well-being for individuals with the condition. This may include regular exercise, a balanced diet, and stress management techniques.

    Can ARMC5 mutations be detected prenatally? 04/04/2016

    Yes, genetic testing can detect ARMC5 mutations prenatally through chorionic villus sampling (CVS) or amniocentesis, if there is a known family history or suspicion of the disorder.

    Customer Reviews (6)

    Write a review
    Reviews
    03/22/2023

      the manufacturer can play a vital role in supporting and optimizing the research process. -

      02/25/2023

        In WB experiments, the ARMC4 Protein consistently delivers exceptional performance. -

        08/20/2022

          Its exceptional purity and integrity ensure clear and reliable bands, enabling accurate detection and quantification of target proteins. -

          09/07/2019

            The manufacturer can offer technical support and expertise to guide researchers through the experimental process. -

            05/19/2018

              manufacturers offer customization options, such as alternative conjugation methods or tailored formulations, allowing researchers to optimize ARMC5 protein to their specific experimental needs. -

              04/21/2017

                This protein has consistently demonstrated outstanding results, making it an indispensable tool in my research endeavors. -

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