aroe
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Bacillus subtilis | AROE-0557B | Recombinant Bacillus subtilis AROE protein, His-tagged | E. coli or Yeast | His | ||
Staphylococcus epidermidis (strain ATCC 35984 / RP62A) | aroE-1140S | Recombinant Staphylococcus epidermidis (strain ATCC 35984 / RP62A) aroE protein, His&Myc-tagged | E.coli | His&Myc | 1-269aa |
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Q&As (8)
Ask a questionThere may be ongoing research studies investigating the shikimate pathway and potential therapeutic targets within it, but specific clinical trials targeting the AroE protein are not known at this time. To get the most up-to-date information on clinical trials, consulting clinical trial registries or scientific databases is recommended.
The regulation of the AroE protein can vary depending on the organism and cellular conditions. In some bacteria, it is regulated transcriptionally, meaning its expression is controlled by certain regulatory elements or transcription factors. Post-translational modifications and allosteric regulation can also impact the activity of the AroE protein, enabling fine-tuning of its function within the shikimate pathway.
Targeting the AroE protein for therapeutic purposes primarily involves the development of inhibitors that can selectively block its activity. Since the shikimate pathway, including the AroE protein, is absent in humans but present in microorganisms, inhibitors can be designed to selectively inhibit microbial growth without harming human cells. This approach is particularly relevant for the development of antibiotics or herbicides.
Yes, the AroE protein is found in most organisms, including bacteria, plants, and fungi. It is essential for the production of aromatic amino acids, which are necessary for protein synthesis and various other biochemical processes in these organisms.
There is limited research on the direct link between mutations or dysregulation of the AroE protein and specific diseases in humans. However, disruptions in the shikimate pathway, where the AroE protein functions, have been associated with metabolic disorders and diseases such as cancer and neurodegenerative disorders. Further studies are needed to determine if specific mutations or dysregulation of the AroE protein can contribute to these conditions.
Although the primary function of the AroE protein is in the shikimate pathway, in some organisms, it may have additional roles beyond aromatic amino acid synthesis. There is evidence that in certain bacteria, the AroE protein may participate in redox processes, playing a role in antioxidant defense or electron transfer pathways.
Polymorphisms, which are variations in the AroE gene, have been identified in different populations. These variations can affect the activity or expression of the AroE protein. However, the clinical significance of these polymorphisms and their impact on diseases or disorders is still not well understood and requires further investigation.
Various techniques are utilized to study the function of the AroE protein. These include recombinant protein expression and purification to analyze its enzymatic activity, site-directed mutagenesis to investigate the role of specific amino acid residues, enzyme kinetics studies to understand its catalytic properties, and structural analysis techniques like X-ray crystallography or cryo-electron microscopy to determine the protein's three-dimensional structure. Additionally, gene knockout or knockdown experiments, along with metabolomics profiling, can be employed to assess the physiological consequences of AroE protein manipulation.
Customer Reviews (3)
Write a reviewThe aroE protein is of exceptional quality and will undoubtedly meet my experimental needs with utmost reliability and accuracy.
I am delighted to highly recommend the aroE Protein for researchers seeking excellent performance in Western blotting (WB) experiments and protein electron microscopy structure analysis
The reliability and reproducibility of the aroE Protein's performance make it a go-to option for WB experiments.
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