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  • Official Full Name

    ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle

  • Overview

    This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the alpha subunit of the catalytic core. Alternatively spliced transcript variants encoding the same protein have been identified. Pseudogenes of this gene are located on chromosomes 9, 2, and 16.
  • Synonyms

    ATP5A1; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1, cardiac muscle , ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 2, non cardiac muscle like 2 , ATP5AL2, ATPM; ATP synthase subunit alpha, mitochondrial; ATP5A; hATP1; OMR; ORM; mitochondrial; ATP synthase alpha chain, mitochondrial; ATP synthase subunit alpha; ATP synthase subunit alpha mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1, cardiac muscle; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 2, non-cardiac muscle-like 2; ATP sythase (F1 ATPase) alpha subunit; ATP5AL2; ATPA_HUMAN; ATPM; Mitochondrial ATP synthetase oligomycin resistant; MOM2; MS502; OTTHUMP00000163475; ATP sythase (F1-ATPase) alpha subunit; mitochondrial ATP synthetase, oligomycin-resistant;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Pig
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • MYC
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP5A1-976H Recombinant Human ATP5A1 protein, GST-tagged Wheat Germ GST
Human ATP5A1-8606H Recombinant Human ATP5A1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ATP5A1-8606HCL Recombinant Human ATP5A1 293 Cell Lysate HEK293 N/A
Human ATP5A1-6637HFL Recombinant Full Length Human ATP5A1 protein, Flag-tagged Mamanlian cells Flag
Human ATP5A1-3983H Recombinant Human ATP5A1 protein, His-tagged E.coli His 202-553 aa
Human ATP5A1-1338HF Recombinant Full Length Human ATP5A1 Protein, GST-tagged In Vitro Cell Free System GST 553 amino acids
Mouse ATP5A1-2129M Recombinant Mouse Atp5a1 protein, Myc/DDK-tagged HEK293 Myc/DDK
Mouse Atp5a1-668M Recombinant Mouse Atp5a1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat ATP5A1-867R Recombinant Rat ATP5A1 Protein Mammalian Cell His
Rat Atp5a1-3707R Recombinant Rat Atp5a1, His-tagged E.Coli or Yeast His 553
Rat ATP5A1-523R Recombinant Rat ATP5A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ATP5A1-523R-B Recombinant Rat ATP5A1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ATP5A1-453R Recombinant Rhesus monkey ATP5A1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ATP5A1-282R-B Recombinant Rhesus Macaque ATP5A1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ATP5A1-282R Recombinant Rhesus Macaque ATP5A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish ATP5A1-4701Z Recombinant Zebrafish ATP5A1 Mammalian Cell His
Pig ATP5A1-3706P Recombinant Pig ATP5A1, GST-tagged E.Coli or Yeast GST 32
Chicken ATP5A1-5859C Recombinant Chicken ATP5A1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ATP5A1 Related Articles

ATP5A1 involved in several pathways and played different roles in them. We selected most pathways ATP5A1 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP5A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Oxidative phosphorylationUQCRQ;ATP6V1C1;NDUFV2;MT-ND1;SDHB;ATP5I;ATP5G3;ATP6V0B;ATP6AP1B
Metabolic pathwaysCkmm;COASY;CMPK2;AGXT2;DAK;AKR1A1B;COX5B2;GATC;ATP5A1

ATP5A1 has several biochemical functions, for example, ATP binding, contributes_to ATPase activity, MHC class I protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP5A1 itself. We selected most functions ATP5A1 had, and list some proteins which have the same functions with ATP5A1. You can find most of the proteins on our site.

Function Related Protein
contributes_to ATPase activityATP5B;ATP5D;ATP5O;ABCG8;SFRP5;PPP2R4;ATP6V1H;MSH2;ATP5E
MHC class I protein bindingDERL1;BCAP31;TUBB;LILRB1;TUBB4B;Pilrb1;TAPBP;TAP1;CD8B
poly(A) RNA bindingZFP326;ZC3HAV1;PTRF;EEF2;GTPBP10;UTP3;PELP1;SAMD4A;GM5506
protein bindingZC3H14;FREM2;HDC;EPB41L3;ERBB3;REV1;BMX;SYF2;IFT172
proton-transporting ATP synthase activity, rotational mechanismATP6AP1;ATP5E;ATP6V0C;ATP5A1;ATP5B;ATP5C1;ATP5O;ATP6AP1B
proton-transporting ATPase activity, rotational mechanismATP6AP1;ATP5E;ATP6V0E;ATP6V0A2;ATP6V0E2;ATP6V1E1;ATP6V0B;ATP6V0CA;ATP6V1F
transmembrane transporter activitySLC22A7A;SLC22A16;ATP5J;SLC22A20;RALBP1;SLC2A11B;ATP5L;SLC2A13B;SLC22A17

ATP5A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP5A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP5A1.


Lucas, EK; Dougherty, SE; et al. PGC-1 alpha Provides a Transcriptional Framework for Synchronous Neurotransmitter Release from Parvalbumin-Positive Interneurons. JOURNAL OF NEUROSCIENCE 34:14375-14387(2014).
Ogura, M; Yamaki, J; et al. Phosphorylation of flotillin-1 by mitochondrial c-Src is required to prevent the production of reactive oxygen species. FEBS LETTERS 588:2837-2843(2014).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What other proteins does ATP5Ainteract with? 02/22/2022

ATP5A1 interacts with other ATP synthase subunits and a variety of mitochondrial proteins (such as NADH dehydrogenase and chromosomal acyl-coa carboxylase) to participate in the process of energy metabolism.

Is the abnormal expression of ATP5Avaluable in the diagnosis and prognosis of neurodegenerative diseases? 07/14/2021

The abnormal expression of ATP5A1 can be used as an important indicator for the diagnosis and prognosis of some neurodegenerative diseases, but it needs to be comprehensively analyzed in combination with other clinical and molecular biological results.

What is the mutation mechanism of ATP5A1? 12/26/2020

Mutations in ATP5A1 may lead to abnormal changes in its intracellular localization and function, thereby affecting mitochondrial neuroregulation and energy metabolism.

What is the role of ATP5Ain biological development? 11/13/2020

ATP5A1 participates in the regulation of cellular energy metabolism and mitochondrial function, and plays an important role in cell growth and development.

Are there any studies on drugs for ATP5Aregulating cellular energy metabolism? 09/30/2020

Yes, several studies have been devoted to the development of drugs that can regulate the activity of ATP5A1 to affect cellular energy metabolism and treat related diseases.

Is the expression pattern of ATP5Aassociated with liver cancer or other tumors? 01/01/2019

Yes, some studies have found that the expression pattern of ATP5A1 is related to the malignant degree and prognosis of liver cancer, bladder cancer, prostate cancer and other tumors.

Customer Reviews (3)

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    It is not easy to be contaminated, and then stored.


      The reproducibility of ATP5A1 is very good, with very consistent results in every experiment or application, benefiting from its high degree of stability and reproducibility.


        Using ATP5A1 as a catalyst, the rate and yield of chemical reactions can be significantly increased with high catalytic efficiency.

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