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ATP6V1G2

Official Full Name

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
Overview

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of three V1 domain G subunit proteins. This gene had previous gene symbols of ATP6G and ATP6G2. Alternatively spliced transcript variants encoding different isoforms have been described. Read-through transcription also exists between this gene and the downstream DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B (DDX39B) gene.
Synonyms

ATP6V1G2; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2; ATP6G, ATP6G2, ATPase, H+ transporting, lysosomal (vacuolar proton pump) , ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G isoform 2; V-type proton ATPase subunit G 2; Em:AC004181.3; NG38; Vma10; ATP6G; ATP6G2; ATPase H+ transporting lysosomal (vacuolar proton pump) subunit G; ATPase H+ transporting lysosomal 13kDa V1 subunit G2; H(+) transporting two sector ATPase subunit G2; NG 38; OTTHUMP00000036058; OTTHUMP00000036060; V ATPase 13 kDa subunit 2; V ATPase G subunit 2; V ATPase subunit G 2; Vacuolar ATP synthase subunit G 2; Vacuolar proton pump G subunit 2; Vacuolar proton pump subunit G 2; VMA 10; OTTHUMP00000029286; OTTHUMP00000165896; OTTHUMP00000215151; V-ATPase 13 kDa subunit 2; H(+)-transporting two-sector ATPase, subunit G2; ATPase, H+ transporting,;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ATP6V1G2-10050H	Recombinant Human ATP6V1G2, GST-tagged	E.coli	GST	C-term-79a.a.	$319 / 25ug
Human	ATP6V1G2-1010H	Recombinant Human ATP6V1G2 protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	ATP6V1G2-8576HCL	Recombinant Human ATP6V1G2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	ATP6V1G2-5657H	Recombinant Human ATP6V1G2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	ATP6V1G2-1538HF	Recombinant Full Length Human ATP6V1G2 Protein, GST-tagged	In Vitro Cell Free System	GST	118 amino acids	Inquiry
Mouse	Atp6v1g2-1776M	Recombinant Mouse Atp6v1g2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rhesus Macaque	ATP6V1G2-471R	Recombinant Rhesus monkey ATP6V1G2 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	ATP6V1G2-300R	Recombinant Rhesus Macaque ATP6V1G2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	ATP6V1G2-300R-B	Recombinant Rhesus Macaque ATP6V1G2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

ATP6V1G2 involved in several pathways and played different roles in them. We selected most pathways ATP6V1G2 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V1G2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Oxidative phosphorylation	ATP6V1G3;SDHB;NDUFS8A;COX7B2;ATP4B;NDUFA6;ATP5IA;ATP6V1G2;NDUFS1
Metabolic pathways	COMTB;IPMKB;GAPDH;POLR3GLB;ZNF408;POLE2;ATP6V0D2;MCAT;BCAT1
Phagosome	STX18;CTSL1B;TUBA4A;NOS1;NCF2;EEA1;ACTB;DYNC1LI1;ACTB1
Synaptic vesicle cycle	ATP6V1D;RAB3A;ATP6V1G1;SLC17A8;SNAP25;ATP6V1E1;ATP6V1B2;NAPA;ATP6V1H
Collecting duct acid secretion	ATP6V1D;ATP6V0E;ATP6V1E1;ATP6V0A1;ATP6V1E2;ATP6V0C;ATP6V1G3;ATP6V1A;ATP6V1G1
Vibrio cholerae infection	ATP6V1A;ATP6V1B1;ATP6V1C1;KDELR3;KDELR1;KDELR2;TJP1;ATP6V1E1;PRKACG
Epithelial cell signaling in Helicobacter pylori infection	ATP6V0D1;MAPK9;TCIRG1;MAP3K14;IL-8;GIT1;CDC42;RAC1;PTPN11
Rheumatoid arthritis	ATP6V0E2;TEK;TNFSF11;Ccl12;HLA-DOB;TGFB3;ATP6V0E1;Il23a;CXCL12

ATP6V1G2 has several biochemical functions, for example, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V1G2 itself. We selected most functions ATP6V1G2 had, and list some proteins which have the same functions with ATP6V1G2. You can find most of the proteins on our site.

Function	Related Protein
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	ATP6V1G2;ATP6V1BA;ATP6V1AA;ATP6V1B1

ATP6V1G2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V1G2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V1G2.

ATP6V1E1; GABARAPL2; IQCB1