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Official Full Name ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
Background This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of three V1 domain G subunit proteins. This gene had previous gene symbols of ATP6G and ATP6G2. Alternatively spliced transcript variants encoding different isoforms have been described. Read-through transcription also exists between this gene and the downstream DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B (DDX39B) gene.
Synonyms ATP6V1G2; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2; ATP6G, ATP6G2, ATPase, H+ transporting, lysosomal (vacuolar proton pump) , ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G isoform 2; V-type proton ATPase subunit G 2; Em:AC004181.3; NG38; Vma10; ATP6G; ATP6G2; ATPase H+ transporting lysosomal (vacuolar proton pump) subunit G; ATPase H+ transporting lysosomal 13kDa V1 subunit G2; H(+) transporting two sector ATPase subunit G2; NG 38; OTTHUMP00000036058; OTTHUMP00000036060; V ATPase 13 kDa subunit 2; V ATPase G subunit 2; V ATPase subunit G 2; Vacuolar ATP synthase subunit G 2; Vacuolar proton pump G subunit 2; Vacuolar proton pump subunit G 2; VMA 10; OTTHUMP00000029286; OTTHUMP00000165896; OTTHUMP00000215151; V-ATPase 13 kDa subunit 2; H(+)-transporting two-sector ATPase, subunit G2; ATPase, H+ transporting,
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ATP6V1G2-10050H Recombinant Human ATP6V1G2, GST-tagged E.coli GST
    Human ATP6V1G2-1010H Recombinant Human ATP6V1G2 protein, GST-tagged Wheat Germ GST
    Human ATP6V1G2-5657H Recombinant Human ATP6V1G2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ATP6V1G2-8576HCL Recombinant Human ATP6V1G2 293 Cell Lysate HEK293 N/A
    Mouse Atp6v1g2-1776M Recombinant Mouse Atp6v1g2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rhesus Macaque ATP6V1G2-471R Recombinant Rhesus monkey ATP6V1G2 Protein, His-tagged Mammalian Cell His

    ATP6V1G2 involved in several pathways and played different roles in them. We selected most pathways ATP6V1G2 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V1G2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Oxidative phosphorylation ATP5H; mt-Atp8; ATP6V1B1; UQCRH; NDUFB11; NDUFAB1; Atp5k; ATP6V1G2; ATP6V1AA; UQCRFS1
    Metabolic pathways GALNTL2; HMGCLL1; NDUFS2; IMPDH1B; UGT2B15; POLR2G; CYP2C45; COX5A; COX6A2; SDSL
    Synaptic vesicle cycle UNC13C; ATP6V0B; CPLX4; ATP6V1B2; RAB3A; ATP6V1B1; ATP6V1C1; SLC18A2; ATP6V1E1; SLC18A1
    Collecting duct acid secretion ATP6V0A2; ATP6V1A; ATP4B; ATP4A; SLC4A1; ATP6V1G1; SLC12A7; ATP6V1C2; ATP6V0D1; ATP6V1C1
    Vibrio cholerae infection PRKACA; ATP6V1H; KDELR3; ATP6V1G2; SEC61G; ATP6V1C2; TJP1; MUC2; PLCG1; PRKACG
    Epithelial cell signaling in Helicobacter pylori infection ATP6V0D2; ATP6V1B2; ATP6V1B1; ATP6V1G3; NOD1; ATP6V0B; RAC1; PLCG1; CXCL1; GIT1
    Rheumatoid arthritis TLR2; CCL3L3; CCL5; TNFRSF11A; ANGPT1; TGFB1; Il23a; HLA-DRA; Ccl12; ATP6AP1

    ATP6V1G2 has several biochemical functions, for example, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V1G2 itself. We selected most functions ATP6V1G2 had, and list some proteins which have the same functions with ATP6V1G2. You can find most of the proteins on our site.

    Function Related Protein
    hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances ATP6V1BA; ATP6V1B1; ATP6V1G2; ATP6V1AA

    ATP6V1G2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V1G2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V1G2.


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