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Itgal

  • Official Full Name

    integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1

  • Overview

    ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide); CD11A; LFA-1; LFA1A; integrin alpha-L; LFA-1A; LFA-1 alpha; integrin gene promoter; CD11 antigen-like family member A; lymphocyte function-associated antigen 1; leukocyte adhesion glycoprotein LFA-1 alpha chain; leukocyte function-associated molecule 1 alpha chain; antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human cell
  • Mammalian cells
  • Yeast
  • C
  • His
  • DYKDDDDK
  • Flag
  • His (Fc)
  • Avi
  • His|Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ITGAL-7134H Recombinant Human ITGAL protein, His & T7-tagged E.coli His/T7 Asn809~His1066 (Accession # P20701)
Human ITGAL-5129HCL Recombinant Human ITGAL 293 Cell Lysate HEK293 N/A
Human ITGAL-168HFL Active Recombinant Full Length Human ITGAL Protein, C-Flag-tagged Mammalian cells Flag
Human ITGAL & ITGB2-7130H Recombinant Human ITGAL & ITGB2 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Human ITGAL-151H Recombinant Human ITGAL Protein, DYKDDDDK-tagged Human cell DYKDDDDK
Human ITGAL-2092H Recombinant Human ITGAL Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ITGAL-1214H Recombinant Human ITGAL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ITGAL-0900H Recombinant Human ITGAL Protein (Asn809-His1066), N-His tagged E.coli N-His Asn809-His1066
Human ITGAL-1214H-B Recombinant Human ITGAL Protein Pre-coupled Magnetic Beads HEK293
Human ITGAL-2691H Recombinant Human ITGAL protein(41-610 aa), C-His-tagged E. coli C-His 41-610 aa
Mouse ITGAL-589M Recombinant Mouse ITGAL Protein (153-325 aa), His-tagged E.coli His 153-325 aa
Mouse ITGAL-1426M Recombinant Mouse ITGAL Protein (153-325 aa), His-tagged Yeast His 153-325 aa
Mouse Itgal-3601M Recombinant Mouse Itgal Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Itgal-7135R Recombinant Rat Itgal protein, His & T7-tagged E.coli His/T7 Leu788~Glu1004 (Accession # Q3T1L6)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Itgal Related Articles

Itgal involved in several pathways and played different roles in them. We selected most pathways Itgal participated on our site, such as Rap signaling pathway, Cell adhesion molecules (CAMs), Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with Itgal were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Rap signaling pathwayGNAI1;PDGFD;PLCG1;PRKCG;PLCB3;TEK;FGF20;PIK3R5;FGF10
Cell adhesion molecules (CAMs)HLA-DOB;PTPRM;LRRC4;CNTNAP2A;CADM1B;CLDN20;NEO1A;CD4;CLDN9
Natural killer cell mediated cytotoxicityITGB2;TYROBP;IFNA17;HLA-E;IFNA8;FCGR4;CD48;NFATC1;HLA-C
Leukocyte transendothelial migrationMAPK12;CLDN9;PIK3CB;ICAM1;ITGAM;PLCG1;ARHGAP35;NCF1;AASS
Regulation of actin cytoskeletonPDGFAB;CHRM5B;ITGB4;CDC42;SSH1;NRAS;WASL;CD14;FGF3
MalariaLRP1;KLRC4-KLRK1;Ccl12;IL-8;THBS4;HGF;TLR9;IL6;HBA-A2
Staphylococcus aureus infectionCFI;C4A;HLA-DPB1;FPR1;DSG1;SELPLG;MBL1;HLA-DMB;DSG1A
HTLV-I infectionPTTG2;NFKBIA;IL6;IL15;IL1R2;BUB3;HLA-DOB;MYB;NFKB1
Epstein-Barr virus infectionPOLR2J2;POLR1C;CD58;PLCG2;POLR2L;TRAF5;TBP;TRADD;RELB
Rheumatoid arthritisATP6V0E1;TGFB2;ATP6V1G2;H2-AA;Il23a; Il12b;TLR4;FOS;CTLA4;IL17A
Viral myocarditisBID;HLA-G;HLA-DOB;ITGB2;FYN;CD28;HLA-DRB4;CXADR;EIF4G2

Itgal has several biochemical functions, for example, ICAM-3 receptor activity, cell adhesion molecule binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Itgal itself. We selected most functions Itgal had, and list some proteins which have the same functions with Itgal. You can find most of the proteins on our site.

Function Related Protein
ICAM-3 receptor activityCLEC4M;ITGB2;ITGAL
cell adhesion molecule bindingCADM3;FGFR1;NPTN;ITGA4;FGG;TENM2;CDH1;PVRL3B;PVRL3
metal ion bindingRNF216;ZNF319;PPM1LA;ZNF16;ZNF558;PKM;RNF121;HDAC9;FGD3
protein bindingCLCF1;SLC25A23;SERPINA1A;TRIM2;ARID1A;RBMY1F;IVL;CNTNAP2;TNFAIP8L2

Itgal has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Itgal here. Most of them are supplied by our site. Hope this information will be useful for your research of Itgal.

PTPRC; q9wmx2-pro_0000037551; env; ICAM1; ICAM3; VHL; Rassf5; RANBP9; MYC

Blanco, FJ; Ojeda-Fernandez, L; et al. Genome-Wide Transcriptional and Functional Analysis of Endoglin Isoforms in the Human Promonocytic Cell Line U937. JOURNAL OF CELLULAR PHYSIOLOGY 230:947-958(2015).
Williams, AS; Kang, L; et al. Integrin alpha 1-null Mice Exhibit Improved Fatty Liver When Fed a High Fat Diet Despite Severe Hepatic Insulin Resistance. JOURNAL OF BIOLOGICAL CHEMISTRY 290:6546-6557(2015).
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