• Official Full Name

    CD209a antigen

  • Overview

    Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA.<br/>On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.
  • Synonyms

    CD209A; CD209a antigen; CIRE; CD209; CDSIGN; Dcsign; SIGNR5; DC-SIGN; SIGN-R1; DC-SIGN1; CD209 antigen-like protein A; dendritic cell-specific ICAM-3-grabbing non-integrin;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Mouse CD209A-3052M Active Recombinant Mouse Cd209a protein, HA-tagged Mammalian cells HA Val73-Lys238
Mouse Cd209a-7174M Recombinant Mouse Cd209a protein, His & T7-tagged E.coli His/T7 Phe115~Lys238 (Accession# Q91ZX1)
Mouse Cd209a-166M-B Recombinant Mouse Cd209a Protein Pre-coupled Magnetic Beads HEK293
Mouse Cd209a-166M Recombinant Mouse Cd209a Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

Cd209a involved in several pathways and played different roles in them. We selected most pathways Cd209a participated on our site, such as Phagosome, Tuberculosis, Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cd209a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

Cd209a has several biochemical functions, for example, calcium-dependent protein binding, carbohydrate binding, carbohydrate derivative binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Cd209a itself. We selected most functions Cd209a had, and list some proteins which have the same functions with Cd209a. You can find most of the proteins on our site.

Function Related Protein
calcium-dependent protein bindingNELF;MBL2;TSG101;CHP;CASQ2;ANXA7;SYT1;KOP;PDCD6IP
carbohydrate bindingZP3;KLRC2;CLEC3B;CHIA;Siglec1;GALNT3;PKD1L3;CLEC4M;HBL4
carbohydrate derivative bindingFCNA;CD209A
mannose bindingCD207;COLEC10;CD209A;DPM1;LMAN2;CLEC4M;MBL2;CD209C;M6PR
metal ion bindingZBTB20;TIMP1;C22orf28;CD209;BA1;SGSH;ZNF800;TOPAZ1;ZNF620
virus receptor activityLAMP1;CD46;LDLR;CLEC5A;CLEC4M;CLDN1;CCR5;ITGB3;SLC1A5

Cd209a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cd209a here. Most of them are supplied by our site. Hope this information will be useful for your research of Cd209a.

  • Reviews
  • Q&As

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        Q&As (5)

        Ask a question
        Could CD209A be a potential target for drug development? 04/26/2022

        Yes, leveraging its role in pathogen recognition, it could be a target for novel therapeutics.

        In what medical conditions has CD209A been studied? 01/08/2022

        Research has focused on its involvement in HIV, hepatitis C, tuberculosis, and other infectious diseases.

        How is CD209A involved in infectious diseases? 10/07/2020

        It facilitates the uptake of pathogens by immune cells, aiding in their detection and subsequent immune response.

        Are there clinical applications for CD209A in infectious diseases? 04/17/2020

        Yes, understanding CD209A's interaction with pathogens can lead to the development of vaccines or treatments targeting this interaction.

        Are there any ongoing clinical trials related to CD209A? 12/30/2016

        Yes, some trials explore how CD209A-targeted therapies might impact disease progression and immune response.

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