• Official Full Name
  • cathepsin F
  • Background
  • Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W.
  • Synonyms
  • CTSF; cathepsin F; CATSF; AI481912; CathepsinF; EC
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CTSF Protein, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CTSF, His-tagged
Source (Host):HEK293Species:Human
Product nameRecombinant Human Cathepsin F, His-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CTSF Protein
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ctsf protein, His & T7-tagged
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CTSF
Source (Host):Species:Human
Product nameRecombinant Human CTSF cell lysate

CTSF Related Articles

Ahn, CS; Na, BK; et al. Expression characteristics and specific antibody reactivity of diverse cathepsin F members of Paragonimus westermani. PARASITOLOGY INTERNATIONAL 64:37-42(2015).
Wongwairot, S; Kueakhai, P; et al. Monoclonal antibody against recombinant Fasciola gigantica cathepsin L1H could detect juvenile and adult cathepsin Ls of Fasciola gigantica. PARASITOLOGY RESEARCH 114:133-140(2015).