DTX1

  • Official Full Name

    deltex homolog 1 (Drosophila)
  • Overview

    Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity.
  • Synonyms

    DTX1;deltex homolog 1 (Drosophila);protein deltex-1;hDx 1;Deltex protein 1;Deltex-1;Deltex1;FXI-T1;Fxit 1;Fxit1;mDTX1;hDTX1;OTTHUMP00000241684;hDx-1

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • Wheat Germ
  • Mammalian Cells
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • T7
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
DTX1-2905H Recombinant Human DTX1 Protein, GST-tagged Wheat Germ Human GST
DTX1-4856M Recombinant Mouse DTX1 Protein Mammalian Cells Mouse His
DTX1-6779Z Recombinant Zebrafish DTX1 Mammalian Cells Zebrafish His
DTX1-1842H Recombinant Human DTX1 protein, His & T7-tagged E.coli Human His&T7 Gly290~His535
DTX1-2548M Recombinant Mouse DTX1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
DTX1-2548M-B Recombinant Mouse DTX1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
DTX1-4067HF Recombinant Full Length Human DTX1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 620 amino acids

    Involved Pathway

    DTX1 involved in several pathways and played different roles in them. We selected most pathways DTX1 participated on our site, such as Notch signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DTX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Notch signaling pathway SNW1,RBPJ,MAML1,NOTCH4,MAML2,HER12,PTCRA,KAT2B,DTX3L,CNTN6

    Protein Function

    DTX1 has several biochemical functions, for example, Notch binding,SH3 domain binding,UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DTX1 itself. We selected most functions DTX1 had, and list some proteins which have the same functions with DTX1. You can find most of the proteins on our site.

    Function Related Protein
    zinc ion binding NR6A1,PRKCG,BPTF,MMP19,MKRN3,SIAH2,ADAMDEC1,AIRE,TRIM108,UQCRC2
    ubiquitin protein ligase binding CUL1B,SCN5A,BAG6,TMEM189,TRAF3,FZD5,RPA3,SMAD2,VCP,PCBP2
    protein-glycine ligase activity, elongating MARCH11,TRIM71,RNF144AB,RC3H2,LTN1,UBR1,UBE2IA,RAG1,RNF180,RNF169
    protein-glycine ligase activity, initiating TRIM41,UBE2IB,NEURL1B,UBR1,TRIM50,RFWD2,ZNRF3,MARCH5L,HERC2,MARCH11
    metal ion binding KCND3,HBAA1,CYP4V8,ELOF1,PHF2,PATZ1,CPXCR1,CDKAL1,ZNF37A,BCL11AA
    protein binding DDR2,PSMD11,TECR,POT1,INCENP,BTG2,RB1CC1,RHOG,ATP6V1E1,PHF20L1
    ligase activity MKRN3,HERC4,RAG1,UHRF1,TRIM41,RNF19B,MARCH10,COP1,MARCH4,RNF182
    tubulin-glutamic acid ligase activity TRIM71,UBR1,MARCH6,SIAH2L,TRIM41,MARCH9,NEURL1B,RNF169,TTLL1,MUL1A
    SH3 domain binding ARHGAP17,DNAJC6,LANCL1,PTPN22,ELMO3,CD2AP,PTTG1,MYPN,SH3BGR,ARHGAP27

    Interacting Protein

    DTX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DTX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DTX1.

    Resources

    Research Area

    Notch Pathway
    Notch Family

    References

    • Aste-Amezaga, M; Zhang, NY; et al. Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors. PLOS ONE 5:-(2010).
    • Laycock, MV; Jellett, JF; et al. First report of a new rapid assay for diarrhetic shellfish poisoning toxins. HARMFUL ALGAE 5:74-78(2006).

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