DVL1
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Official Full Name
dishevelled, dsh homolog 1 (Drosophila)
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Overview
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. -
Synonyms
DVL1; dishevelled, dsh homolog 1 (Drosophila); dishevelled 1 (homologous to Drosophila dsh); segment polarity protein dishevelled homolog DVL-1; Dishevelled 1; dishevelled 1 like; Dishevelled; Dishevelled dsh homolog 1; Dishevelled-1; Dishevelled1; DSH homolog 1; Dvl 1; Dvl; DVL1_HUMAN; DVL1L1; MGC54245; Segment polarity protein dishevelled homolog DVL 1; segment polarity protein dishevelled homolog DVL 1 like; Segment polarity protein dishevelled homolog DVL1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- T7
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- DVL1 Related Signal Pathway
DVL1 involved in several pathways and played different roles in them. We selected most pathways DVL1 participated on our site, such as Adipogenesis, Basal cell carcinoma, Beta-catenin independent WNT signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with DVL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Adipogenesis | CFD;CDKN1A;KLF7;FRZB;NRIP1;HMGA1;NCOA2;STIL;CREB1 |
Basal cell carcinoma | SMO;BMP2;FZD3;WNT4;FZD2;WNT5B;TP53;AXIN2;GLI3 |
Beta-catenin independent WNT signaling | AP2B1;CTNNB2;CLTA;CLTB;MOV10;AGO1;DVL3;AP2A1;AP2S1 |
Canonical Wnt signaling pathway | DVL1;CSNK1D;CSNK1A1;DVL2;CSNK1E;KLHL12;DVL3 |
DNA damage response (only ATM dependent) | DVL1;BIK;MLKL;DVL3;DVL2 |
Degradation of DVL | DVL2;HECW1B;DVL3;KLHL12;HECW1;DACT1;DVL1 |
Disassembly of the destruction complex and recruitment of AXIN to the membrane | DVL3;DVL1;DVL2;CSNK1G2;WNT8-2 |
HTLV-I infection | IKBKB;CREM;GM-CSF;BUB3;WNT7B;GPS2;SMAD2;POLD4;NFATC2 |
DVL1 has several biochemical functions, for example, Rac GTPase binding, enzyme binding, frizzled binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DVL1 itself. We selected most functions DVL1 had, and list some proteins which have the same functions with DVL1. You can find most of the proteins on our site.
Function | Related Protein |
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Rac GTPase binding | PAK2;NOX1;HACE1;DOCK7;ARFIP2;NOXA1;RAB7A;MAP3K11;SRGAP2 |
enzyme binding | HIST1H2AM;NOXO1;PRKCE;MARCH6;Slc4a2;HIST1H2AD;HIST1H2AK;NCOA1;GSTM4 |
frizzled binding | SDCBP;WNT4;CTHRC1;RSPO3;WNT11R;WNT10B;DVL1;DVL3;RNF43 |
identical protein binding | PRKAB2;HCFC1;DPP9;NCAM1;GOT1;SNRNP200;PPP1R13L;BCAT1;SH3BP4 |
molecular_function | SRRD;IFT80;ZNF114;HDHD1A;GREB1L;MPV17L;TMEM240;GUCD1;CNRIP1A |
protein binding | ATG7;NDFIP2;NDUFS3;PRKD3;BAG4;OSR2;L3MBTL2;FAM131C;CHAC1 |
protein kinase binding | SHC3;LATS1;NBEA;PRKACA;SPAG16;PPME1;SHC1;SPDYB;YWHAZ |
DVL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DVL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DVL1.
Axin1; CSNK1E; DVL3
Research Area
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