DVL2
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Official Full Name
dishevelled, dsh homolog 2
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Overview
Dishevelled (Dsh) proteins are important intermediates of Wnt signaling pathways. Dsh inhibits glycogen synthase kinase-3beta promoting beta-catenin stabilization. Dsh proteins also participate in the planar cell polarity pathway by acting through JNK. Th -
Synonyms
DVL2; dishevelled, dsh homolog 2 (Drosophila); dishevelled 2 (homologous to Drosophila dsh); segment polarity protein dishevelled homolog DVL-2; DSH homolog 2; dishevelled-2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- C
- Strep
- Flag
- GST
- His
- Fc
- Avi
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- DVL2 Related Signal Pathway
DVL2 involved in several pathways and played different roles in them. We selected most pathways DVL2 participated on our site, such as Asymmetric localization of PCP proteins, Basal cell carcinoma, Beta-catenin independent WNT signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with DVL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Asymmetric localization of PCP proteins | PRICKLE1B;PRICKLE1;DVL2 |
| Basal cell carcinoma | STK36;FZD3;WNT2;WNT7A;Fzd4;WNT3A;WNT2B;WNT9A;FZD7 |
| Beta-catenin independent WNT signaling | RYK;AGO3;GNB5;CLTA;AP2B1;ROR2;ROR1;MOV10;PRICKLE1B |
| Canonical Wnt signaling pathway | DVL3;DVL2;CSNK1E;CSNK1D;CSNK1A1;DVL1;KLHL12 |
| DNA damage response (only ATM dependent) | DVL3;MLKL;DVL1;BIK;DVL2 |
| Degradation of DVL | DACT1;HECW1B;DVL2;DVL1;KLHL12;DVL3;HECW1 |
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | WNT8-2;CSNK1G2;DVL1;DVL3;DVL2 |
| HTLV-I infection | XPO1;MSX2;HLA-DPB1;PIK3R3;TCF3;HLA-F;LTBR;MAP3K1;RELA |
DVL2 has several biochemical functions, for example, frizzled binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DVL2 itself. We selected most functions DVL2 had, and list some proteins which have the same functions with DVL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| frizzled binding | WNT1;DVL2;MYOC;WNT4A;RSPO3;WNT7B;WNT9A;WNT3;WNT2BA |
| identical protein binding | PRDX3;PYCARD;THG1L;DYNLT1A;PRC1;CEP57L1;IAPP;CCDC109A;FKBP8 |
| protein binding | TRPV4;DICER1;SHD;TSC2;TRIAP1;MRPS23;DPF2;CLK3;NPC1 |
| protein domain specific binding | DYNLL1;TNNI3;TNFAIP1;ICA1;RUNX2;SORBS2;AIDA;GUSB;YWHABA |
| protein self-association | AGXT;LDB1;ZSWIM2;SVIP;PABPN1;DVL2;TTN;AGA;AGTR1B |
DVL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DVL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DVL2.
DACT1; Smurf2; Pard6a
Research Area
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