• Official Full Name

    fatty acid binding protein 4, adipocyte

  • Background

    FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]
  • Synonyms

    FABP4; fatty acid binding protein 4, adipocyte; aP2; ALBP; AFABP; A-FABP; HEL-S-104; fatty acid-binding protein, adipocyte; fatty acid-binding protein 4; adipocyte lipid-binding protein; epididymis secretory protein Li 104; adipocyte-type fatty acid-binding protein;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Assay Kits
    • Species :
    • Cattle
    • Chicken
    • Human
    • Mouse
    • Pig
    • Rat
    • Rhesus Macaque
    • Sheep
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293F
    • HEK293T
    • Human Cell
    • In Vitro Cell Free System
    • Mamanlian cells
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Flag
    • GST
    • His
    • His (Fc)
    • Avi
    • His|GST
    • His|Myc
    • His|T7
    • Myc
    • DDK
    • MYC
    • Myc|DDK
    • N/A
    • N
    Species Cat.# Product name Source (Host) Tag Price
    Human FABP4-652H Recombinant Human FABP4 protein, MYC/DDK-tagged, C13/N15-labeled HEK293 Myc/DDK
    Human FABP4-26819TH Recombinant Human FABP4, His-tagged E.coli His
    Human FABP4-3951H Recombinant Human FABP4 protein, His-tagged E.coli His
    Human FABP4-3636H Recombinant Human FABP4 E.coli N/A
    Human FABP4-268H Recombinant Human Fatty Acid Binding Protein (Adipocyte),His-tagged E.coli His
    Human FABP4-12634H Recombinant Human FABP4, GST-tagged E.coli GST
    Human FABP4-440H Recombinant Human FABP4 protein, His-tagged HEK293F His
    Human FABP4-3635H Recombinant Human FABP4 Protein, GST-tagged Wheat Germ GST
    Human FABP4-4423HF Recombinant Full Length Human FABP4 Protein, GST-tagged In Vitro Cell Free System GST
    Human FABP4-3671HFL Recombinant Full Length Human FABP4 protein, Flag-tagged Mamanlian cells Flag
    Human FABP4-917H Recombinant Human FABP4 Protein, His-tagged HEK293F N-His
    Human FABP4-3179H Recombinant Human FABP4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human FABP4-2561H Recombinant Human FABP4 protein E.coli N/A
    Human FABP4-151H Recombinant Human FABP4 protein, His-tagged E.coli His
    Human FABP4-2592H Recombinant Human FABP4 protein E.coli N/A
    Mouse Fabp4-3317M Recombinant Mouse Fabp4, His tagged Human Cell His
    Mouse Fabp4-449M Recombinant Mouse Fabp4 protein, His-tagged HEK293F His
    Mouse Fabp4-12633M Recombinant Mouse Fabp4, GST-tagged E.coli GST
    Mouse Fabp4-4068M Recombinant Mouse Fabp4, His tagged E.coli His
    Mouse Fabp4-1004M Recombinant Mouse Fatty Acid Binding Protein 4, Adipocyte, His-tagged E.coli His
    Mouse FABP4-2379MCL Recombinant Mouse FABP4 cell lysate Human Cell N/A
    Mouse FABP4-831M Recombinant Mouse FABP4 Protein (Cys2-Ala132), His-MYC-tagged HEK293 His/Myc
    Mouse Fabp4-133M Recombinant Mouse Fabp4 protein, GST-tagged E. coli GST
    Mouse Fabp4-620M Recombinant Mouse Fabp4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat Fabp4-1811R Recombinant Rat Fabp4 protein, His & T7-tagged E.coli His/T7
    Cattle FABP4-916C Recombinant Cattle FABP4 Protein, His-tagged E.coli N-His
    Rhesus Macaque FABP4-1536R Recombinant Rhesus monkey FABP4 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque FABP4-1361R Recombinant Rhesus Macaque FABP4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque FABP4-1361R-B Recombinant Rhesus Macaque FABP4 Protein Pre-coupled Magnetic Beads HEK293
    Sheep FABP4-918S Recombinant Sheep FABP4 Protein, His-tagged E.coli N-His
    Pig FABP4-1810P Recombinant Pig FABP4 protein, His & GST-tagged E.coli His/GST
    Chicken FABP4-1809C Recombinant Chicken FABP4 protein, His & T7-tagged E.coli His/T7
    Chicken FABP4-5863C Recombinant Chicken FABP4 Mammalian Cell His
    Kit-1954 FABP4 Inhibitor/Ligand Screening Assay Kit N/A
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • Fabp4 Related Articles
    • Fabp4 Related Research Area

    Fabp4 involved in several pathways and played different roles in them. We selected most pathways Fabp4 participated on our site, such as PPAR signaling pathway, Regulation of lipolysis in adipocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fabp4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Regulation of lipolysis in adipocytesFABP4;IRS2;GNAI2;TSHR;GNAI3;GNAS;INS;PLIN1;PNPLA2

    Fabp4 has several biochemical functions, for example, fatty acid binding, transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Fabp4 itself. We selected most functions Fabp4 had, and list some proteins which have the same functions with Fabp4. You can find most of the proteins on our site.

    Function Related Protein
    transporter activitySCARB1;MFSD10;RLBP1;ATP5G1;SLCO1B2;ABCA4A;AQP12B;TTPA;CSN2

    Fabp4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fabp4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fabp4.


    Girona, J; Rosales, R; et al. FABP4 Induces Vascular Smooth Muscle Cell Proliferation and Migration through a MAPK-Dependent Pathway. PLOS ONE 8:-(2013).
    Bee, C; Abdiche, YN; et al. Determining the Binding Affinity of Therapeutic Monoclonal Antibodies towards Their Native Unpurified Antigens in Human Serum. PLOS ONE 8:-(2013).
    • Q&As
    • Reviews

    Q&As (7)

    Ask a question
    How is FABP4 involved in the development and progression of metabolic diseases? 05/31/2023

    FABP4 is implicated in the development and progression of metabolic diseases due to its influence on lipid metabolism and inflammation. Elevated FABP4 expression is observed in adipose tissue and macrophages in obese individuals. FABP4 promotes lipid accumulation, insulin resistance, and the production of pro-inflammatory cytokines, leading to adipose tissue dysfunction and systemic metabolic abnormalities. Inhibition or genetic depletion of FABP4 has been shown to improve metabolic parameters in animal models, highlighting its potential as a therapeutic target for metabolic diseases.

    an FABP4 be used as a biomarker for metabolic disorders? 11/10/2021

    FABP4 has been investigated as a potential biomarker for metabolic disorders, including obesity and type 2 diabetes. Studies have shown that circulating levels of FABP4 are elevated in individuals with these conditions. Increased FABP4 levels have also been associated with insulin resistance, dyslipidemia, and cardiovascular risk factors. However, further research is needed to validate FABP4 as a reliable biomarker and to determine its clinical utility in the diagnosis, prognosis, and monitoring of metabolic diseases.

    How does FABP4 interact with other proteins and signaling pathways? 05/05/2021

    FABP4 interacts with various proteins and signaling pathways to regulate lipid metabolism and inflammation. For instance, FABP4 interacts with PPARγ, a key transcription factor involved in adipogenesis and lipid metabolism. This interaction influences the expression of genes involved in lipid uptake and storage. FABP4 also interacts with inflammatory signaling pathways, such as NF-κB and JNK, modulating the production of pro-inflammatory cytokines. Understanding the molecular interactions of FABP4 can provide insights into its functional roles and potential targets for therapeutic intervention.

    What is the role of genetic variants in FABP4 in metabolic disorders? 12/20/2019

    Genetic variants in the FABP4 gene have been associated with metabolic disorders. Single nucleotide polymorphisms (SNPs) in the FABP4 gene have been linked to obesity, insulin resistance, and dyslipidemia. These genetic variants may alter FABP4 expression, protein structure, or function, leading to dysregulated lipid metabolism and increased susceptibility to metabolic diseases. Further investigation is needed to elucidate the functional consequences of these genetic variants and their potential as predictive markers for metabolic disorders.

    What are the potential therapeutic strategies targeting FABP4? 02/15/2019

    Various therapeutic strategies targeting FABP4 have been explored. Small molecule inhibitors of FABP4 have shown promising results in preclinical studies, attenuating lipid accumulation, improving insulin sensitivity, and reducing inflammation. Additionally, gene silencing approaches, such as RNA interference, have been investigated to suppress FABP4 expression. Furthermore, modulation of FABP4 activity through natural compounds and lifestyle interventions, such as exercise and dietary modifications, may also hold therapeutic potential. However, more research is required to evaluate the safety and efficacy of these strategies in human subjects.

    What is the biological function of FABP4 in cellular processes and metabolism? 06/13/2017

    FABP4, also known as fatty acid-binding protein 4, plays a crucial role in lipid metabolism and cellular processes. It functions as an intracellular transporter for fatty acids, facilitating their uptake, storage, and utilization. Additionally, FABP4 modulates inflammation, insulin sensitivity, and adipocyte differentiation. Its expression is regulated by various factors such as PPARγ and C/EBPα. FABP4 dysregulation has been associated with metabolic disorders, such as obesity and type 2 diabetes, making it an important target for therapeutic interventions.

    How does FABP4 contribute to the pathogenesis of cardiovascular diseases? 01/14/2016

    FABP4 has been implicated in the pathogenesis of cardiovascular diseases due to its involvement in lipid metabolism, inflammation, and atherosclerosis. Elevated FABP4 levels have been observed in individuals with coronary artery disease, and FABP4 has been shown to promote foam cell formation, a key step in atherosclerotic plaque development. FABP4 also influences vascular endothelial function and thrombosis. Inhibition of FABP4 has demonstrated beneficial effects on atherosclerosis progression and cardiovascular outcomes in experimental models. Further research is needed to fully understand the mechanisms underlying the contribution of FABP4 to cardiovascular diseases.

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