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FDXR

  • Official Full Name

    Ferredoxin Reductase

  • Overview

    Ferredoxin reductase is a ubiquitous flavoenzyme, containing noncovalently bound FAD as a prosthetic group. It plays a role in delivering NADPH or low potential one-electron donors such as ferredoxin and flavodoxin to redox-based metabolisms in plastids, mitochondria and bacteria. In mammals, ferredoxin reductase is loosely associated with the inner mitochondrial membrane and receives electrons from NADPH. These electrons are transferred to ferredoxin which shuttles electrons to cytochrome P450 in the adrenal cortex mitochondrial steroid hydroxylation systems.
  • Synonyms

    FDXR; ferredoxin reductase; ADXR; NADPH: adrenodoxin oxidoreductase, mitochondrial; AR; adrenodoxin reductase; ferredoxin--NADP(+) reductase; NP_004101.2; EC 1.18.1.2; NP_077728.2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • E.coli
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FDXR-15H Recombinant Human FDXR protein, His-tagged E.coli His
Human FDXR-12836H Recombinant Human FDXR, GST-tagged E.coli GST 142-491a.a.
Human FDXR-16H Recombinant Human FDXR protein, MYC/DDK-tagged HEK293 Myc/DDK
Human FDXR-12H Recombinant Human FDXR protein, His/T7-tagged E.coli His/T7 Ser33~Arg219
Human FDXR-6268HCL Recombinant Human FDXR 293 Cell Lysate HEK293 N/A
Human FDXR-3406H Recombinant Human FDXR protein, His-tagged E.coli His 142-491 aa
Human FDXR-1648H Recombinant Human FDXR Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FDXR-4777HF Recombinant Full Length Human FDXR Protein, GST-tagged In Vitro Cell Free System GST 491 amino acids
Human FDXR-4063H Recombinant Human FDXR Protein, GST-tagged Wheat Germ GST
Human FDXR-2898H Recombinant Human FDXR protein, His-SUMO-tagged E.coli His-SUMO 33-451aa
Mouse Fdxr-2983M Recombinant Mouse Fdxr Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Fdxr-1728M Recombinant Mouse Fdxr protein, His & T7-tagged E.coli His/T7 Ser35~Gly252 (Accession # Q61578)
Rat FDXR-2311R Recombinant Rat FDXR Protein Mammalian Cell His
Rat FDXR-1968R-B Recombinant Rat FDXR Protein Pre-coupled Magnetic Beads HEK293
Rat FDXR-1968R Recombinant Rat FDXR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bovine FDXR-2650B Recombinant Bovine FDXR Protein (33-492 aa), His-tagged Yeast His 33-492 aa
Bovine FDXR-2897B Recombinant Bovine FDXR protein, His-tagged E.coli His 33-492aa
E.coli FDXR-2626B Recombinant Bovine FDXR Protein (33-492 aa), His-tagged E.coli His 33-492 aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

FDXR involved in several pathways and played different roles in them. We selected most pathways FDXR participated on our site, such as Biological oxidations, Cytochrome P450 - arranged by substrate type, Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR), which may be useful for your reference. Also, other proteins which involved in the same pathway with FDXR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Biological oxidationsCYP7A1;CYP21A2;CYP2K6;CYP27A1;ADH6;FDX1L;COMT;SULT1C4;CYP26A1
Cytochrome P450 - arranged by substrate typeCYP2K18;CYP2W1;CYP4T8;CYP1A1;CYP2J2;CYP2N13;CYP4B1;CYP11B2;CYP2K6
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)FDX1L;CYP11A1;FDX1;FDXR
Direct p53 effectorsDGCR8;CSE1L;CEBPZ;EDN2;PPM1J;SMARCA4;FDXR;DUSP5;PCBP4
DiseaseMTRR;CHMP4B;JAG2;AP2A1;BANF1;TRAT1;AMN;TTR;MMAA
Diseases of metabolismMMADHC;GYG2;FDXR;FDX1L;FDX1;CYP11A1;MTRR;GYG1;SFTPC
Electron transport from NADPH to FerredoxinFDX1L;FDXR;FDX1
Endogenous sterolsCYP11B1;POMCB;FDX1;CYP11B2;CYP8B2;FDXR;CYP19A1;FDX1L;CYP7A1

FDXR has several biochemical functions, for example, NADPH-adrenodoxin reductase activity, ferredoxin-NADP+ reductase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FDXR itself. We selected most functions FDXR had, and list some proteins which have the same functions with FDXR. You can find most of the proteins on our site.

Function Related Protein
NADPH-adrenodoxin reductase activity
ferredoxin-NADP+ reductase activity
protein bindingPPP2CA;RGS17;AP1B1;ENTPD5;ARFRP1;ZBTB1;MRM1;FOXP2;HBB

FDXR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FDXR here. Most of them are supplied by our site. Hope this information will be useful for your research of FDXR.

FHIT; HSPD1

Research Area

Related articles

Wang, JL; Guise, CP; et al. Identification of one-electron reductases that activate both the hypoxia prodrug SN30000 and diagnostic probe EF5. BIOCHEMICAL PHARMACOLOGY 91:436-446(2014).
Imamichi, Y; Mizutani, T; et al. Transcriptional regulation of human ferredoxin reductase through an intronic enhancer in steroidogenic cells. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1839:33-42(2014).
  • Q&As
  • Reviews

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Customer Reviews (3)

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Reviews
02/06/2023

    The technical expert will follow up on the progress of my experiments and provide constructive advice on the problems that arise in my experiments.

    11/14/2022

      Cheap price, high quality products, worth buying again.

      04/01/2022

        The product was kept in perfect condition and delivered on time so that I got the perfect product in the shortest time possible.

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