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KLF11

Official Full Name

Kruppel-like factor 11
Overview

The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene.
Synonyms

KLF11; Kruppel-like factor 11; TGFB inducible early growth response 2 , TIEG2; Krueppel-like factor 11; MODY7; Tieg3; TIEG-2; TGFB-inducible early growth response protein 2; transforming growth factor-beta-inducible early growth response protein 2; FKLF;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
Mammalian Cell

Tag

GST|His
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	KLF11-087H	Recombinant Human KLF11 Protein, GST-HIS-tagged	E.coli	GST/His	Inquiry
Human	KLF11-4932HCL	Recombinant Human KLF11 293 Cell Lysate	HEK293	N/A	Inquiry
Mouse	KLF11-8675M	Recombinant Mouse KLF11 Protein	Mammalian Cell	His	Inquiry
Mouse	KLF11-4834M-B	Recombinant Mouse KLF11 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	KLF11-4834M	Recombinant Mouse KLF11 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Chicken	KLF11-1559C	Recombinant Chicken KLF11	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
KLF11 Related Articles

KLF11 involved in several pathways and played different roles in them. We selected most pathways KLF11 participated on our site, such as EGFR1 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLF11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
EGFR1 Signaling Pathway	CRKL;PTPN12;TNIP1;EPS8;PLSCR1;SPRY2;PITPNAA;RALBP1;CEACAM1

KLF11 has several biochemical functions, for example, RNA polymerase II transcription factor activity, sequence-specific DNA binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLF11 itself. We selected most functions KLF11 had, and list some proteins which have the same functions with KLF11. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II transcription factor activity, sequence-specific DNA binding	ZNF202;RUNX3;SOX14;SPI1;NPAS4;ELF5;FOXA2;TFDP1A;POU5F1
metal ion binding	ZNF839;TRIT1;WBP7;KEX2;HGD;LMAN1;ITGAM;AFP;ZFP27
protein binding	RAB11B;MYO7B;GNPDA2;FOXO1;SENP7;TBX24;IPO13;EHD1;VEGFAA
transcription factor activity, sequence-specific DNA binding	SOLH;OTX1B;EGR2;ZNF624;SNAPC4;SCAND3;ZNF133;NFIC;GATAD2AB
transcription regulatory region DNA binding	Ar;KLF15;SALL3;SOX5;XBP1;DHX36;THRA;RREB1;HHEX

KLF11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLF11 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLF11.

TXNDC9; APPBP2; g3h0f0_crigr; CLU; HTT; ATXN1; YWHAZ; q81ye8_bacan; APH1A; TIMM13

Grisaru-Granovsky, S; Salah, Z; et al. Protease-activated-receptor 1 polymorphisms correlate with risk for unexplained recurrent pregnancy loss: a pilot study querying an association beyond coagulation. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY 185:13-18(2015).

Loft, A; Forss, I; et al. Browning of human adipocytes requires KLF11 and reprogramming of PPAR gamma superenhancers. GENES & DEVELOPMENT 29:7-22(2015).