KRT17
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Official Full Name
Keratin 17
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Background
This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychiacongenita and steatocystoma multiplex. -
Synonyms
PC; K17; PC2; PCHC1; KRT17; keratin, type I cytoskeletal 17; 39.1; CK-17; keratin-17; cytokeratin-17; OTTHUMP00000164770;
- Involved Pathway
- Protein Function
- Interacting Protein
KRT17 involved in several pathways and played different roles in them. We selected most pathways KRT17 participated on our site, such as EGFR1 Signaling Pathway, Glucocorticoid receptor regulatory network, which may be useful for your reference. Also, other proteins which involved in the same pathway with KRT17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| EGFR1 Signaling Pathway | PLSCR1;RGS16;ZNF259;PTPN12;PTK6;RALBP1;USP6NL;SH2D3C;KLF11 |
| Glucocorticoid receptor regulatory network | SMARCD1;BGLAP;EGR1;CSN2;SMARCA4;KRT17;NR1I3;SMARCC2;KRT14 |
KRT17 has several biochemical functions, for example, MHC class II protein binding, MHC class II receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KRT17 itself. We selected most functions KRT17 had, and list some proteins which have the same functions with KRT17. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| MHC class II protein binding | CD4;LAG3;KRT17;MARCH8;CD74A;CD74;CD74B |
| MHC class II receptor activity | HLA-DQA2;HLA-DOB;HLA-DRA;HLA-DQA1;HLA-DRB4;HLA-DQB1;HLA-DRB1;HLA-DPA1;HLA-DOA |
| protein binding | GLA;ATRNL1;TMPO;GLYCTK;RPN1;NSF;ARMCX5;SGOL1;IL12A |
| structural constituent of cytoskeleton | TUBB1;NEFH;TUBA8L4;ANK1;ACTA1;ACTR2;TUBA1A;TUBA1L;ACTG1 |
KRT17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KRT17 here. Most of them are supplied by our site. Hope this information will be useful for your research of KRT17.
CCDC85B; USP1; UCHL1; KDM1A; SNAPIN; KRT6A; APC; ZDHHC17; midostaurin; EGFR; CFTR; GRB2; YWHAZ; NETO2; GABARAPL1
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