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LASS4

Official Full Name

ceramide synthase 4
Overview

Ceramide synthase 4 (CerS4) is an enzyme that in humans is encoded by the CERS4 gene and is one of the least studied of the ceramide synthases.
Synonyms

LAG1 homolog, ceramide synthase 4; CerS4; FLJ12089; Trh1; LAG1 longevity assurance homolog 4 (S. cerevisiae); LAG1 longevity assurance homolog 4; LASS4; ceramide synthase 4;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Mouse	LASS4-8966M	Recombinant Mouse LASS4 Protein	Mammalian Cell	His	Inquiry
Mouse	LASS4-5000M-B	Recombinant Mouse LASS4 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	LASS4-5000M	Recombinant Mouse LASS4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry

Involved Pathway
Protein Function
Interacting Protein
LASS4 Related Articles

LASS4 involved in several pathways and played different roles in them. We selected most pathways LASS4 participated on our site, such as Sphingolipid metabolism, Metabolic pathways, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LASS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Sphingolipid metabolism	CERS4A;PPAP2A;SUMF2;ARSK;R05D11.9;ASAH1B;ASAH1A;SMPD2;PPAP2C
Metabolic pathways	PKLR;MBOAT2B;PLA2G2D;COX4I2;NDUFA7;ACOT5;NAMPTB;MAN2A1;SARDH
Sphingolipid signaling pathway	PIK3CD;PIK3R3;PPP2R5B;ACER1;ASAH1;ABCC1;GNAI1;PPP2CB;PRKCG

LASS4 has several biochemical functions, for example, DNA binding, sphingosine N-acyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LASS4 itself. We selected most functions LASS4 had, and list some proteins which have the same functions with LASS4. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	E2F5;ZNF398;NR1D2A;MEF2C;SREBF1;MYC;ZNF599;TRIM27;THRAA
sphingosine N-acyltransferase activity	LASS5;LASS4;CERS4;CERS4A;LASS1;CERS3B;FAM57B;CERS2A;CERS5

LASS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LASS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of LASS4.

Ebel, P; Imgrund, S; et al. Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia. BIOCHEMICAL JOURNAL 461:147-158(2014).

Haller, JF; Cavallaro, P; et al. Endogenous beta-glucocerebrosidase activity in Abca12(-/-) epidermis elevates ceramide levels after topical lipid application but does not restore barrier function. JOURNAL OF LIPID RESEARCH 55:493-503(2014).