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M2

Official Full Name

Matrix protein M2
Overview

The Matrix protein M2 forms a protons channel. When the environmental pH is lower than a threshold, the M2 channel is activated and selectively transports protons accross the membrane from the extracellular side to the cytoplasmic side. It is crucial for the uncoating process. When the virion is internalized into the endosome the channel can acidify the virion interior, promoting the dissociation of the viral matrix protein (M1) from the ribonucleoprotein (RNP) thus allowing the transport of the RNP from the virion into the cell's nucleus. For some influenza virus subtypes, the M2 channel can elevate the intravesicular pH of the trans Golgi network, preventing the viral protein haemagglutinin, which is transported to the cell surface through the trans Golgi network, from incorrect maturation in an otherwise low pH environment.
Synonyms

Influenza A Virus M2 Protein; Influenza A; Influenza Aantigen; Isavirus; Thogotovirus; Orthomyxoviridae; Matrix protein M2; matrix (M2/22K); M2/22K; Matrix; Influenza A virus matrix protein M2; M; M2; Membrane ion channel M2; Membrane protein M2; Proton channel protein M2; Influenza A Virus M2 Protein; M2 Protein;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Influenza A virus	M2-4376I	Recombinant Influenza A virus M2 Full Length Transmembrane protein, His&Myc-tagged	In vitro E. coli expression system	His&Myc	1-97aa	Inquiry
Influenza A virus	RFL2949IF	Recombinant Full Length Influenza A Virus Matrix Protein 2(M2) Protein, His&Myc-Tagged	E.coli expression system	His&Myc	Full Length (1-97aa)	Inquiry
Rabies Virus	M2-399V	Recombinant Rabies Virus M2 Matrix Protein, His-tagged	E.coli	His		Inquiry

Other Resource

M2 involved in several pathways and played different roles in them. We selected most pathways M2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with M2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

M2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by M2 itself. We selected most functions M2 had, and list some proteins which have the same functions with M2. You can find most of the proteins on our site.

Function	Related Protein

M2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with M2 here. Most of them are supplied by our site. Hope this information will be useful for your research of M2.

Research Area

Zandberg, DP; Rollins, S; et al. A phase I dose escalation trial of MAGE-A3-and HPV16-specific peptide immunomodulatory vaccines in patients with recurrent/metastatic (RM) squamous cell carcinoma of the head and neck (SCCHN). CANCER IMMUNOLOGY IMMUNOTHERAPY 64:367-379(2015).

Dale, JB; Niedermeyer, SE; et al. Protective Immunogenicity of Group A Streptococcal M-Related Proteins. CLINICAL AND VACCINE IMMUNOLOGY 22:344-350(2015).