MLXIPL
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Official Full Name
MLX interacting protein-like -
Overview
This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. -
Synonyms
MLXIPL;MLX interacting protein-like;WBSCR14, Williams Beuren syndrome chromosome region 14;carbohydrate-responsive element-binding protein;bHLHd14;carbohydrate response element binding protein;CHREBP;MIO;MONDOB;WS bHLH;Carbohydrate responsive element binding protein;Class D basic helix-loop-helix protein 14;MLX interacting protein like;Mlx interactor;MLX-interacting protein-like;WBS14_HUMAN;WBSCR 14;WBSCR14;Williams Beuren syndrome chromosome region 14;Williams Beuren syndrome chromosome region 14 protein;Williams-Beuren syndrome chromosomal region 14 protein;WS basic helix loop helix leucine zipper protein;WS basic-helix-loop-helix leucine zipper protein;WS-bHLH;Williams-Beuren syndrome chromosome region 14 protein 1;Williams-Beuren syndrome chromosome region 14 protein 2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MLXIPL-111H | Recombinant Human MLXIPL, GST-tagged | Wheat Germ | Human | GST |
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| MLXIPL-2041H | Recombinant Human MLX Interacting Protein-Like, GST-tagged | E.coli | Human | GST | Full L. 648-741 a.a. |
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| MLXIPL-3773C | Recombinant Chicken MLXIPL | Mammalian Cells | Chicken | His |
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Involved Pathway
MLXIPL involved in several pathways and played different roles in them. We selected most pathways MLXIPL participated on our site, such as Insulin resistance,Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with MLXIPL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin resistance | PRKCZ,PRKAB1A,PPP1CAB,PRKAG3B,ACACB,PIK3CD,CREB3L3L,PIK3R2,TNF,TBC1D4 |
| Non-alcoholic fatty liver disease (NAFLD) | EIF2AK3,NDUFV2,GSK3A,NDUFC1,NDUFS4,INS,NDUFA2,COX5A,NFKB1,Casp3 |
Protein Function
MLXIPL has several biochemical functions, for example, contributes_to DNA binding,DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MLXIPL itself. We selected most functions MLXIPL had, and list some proteins which have the same functions with MLXIPL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | HOXB5B,ZSCAN18,INSM1A,NKX2.5,ZFP473,ZFP771,ZNF488,CREM,KDM5BB,RMI2 |
| contributes_to DNA binding | GTF3C2,SMAD4,ARNTL1B,CLOCKA,RFC3,NFE2L2A,SMAD2,MRE11A,GTF3C4,MAFGA |
| transcription factor activity, sequence-specific DNA binding | HOXC8,ENO1,ZKSCAN14,CSRNP1,E2F8,GABPA,SIX1B,Aff1,ETV5A,POU3F2A |
| protein heterodimerization activity | TPD52,ADORA1,CENPA,HEXB,UGT1A1,ATF3,POLE3,ADRA2C,PEF1,PKNOX1 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | PITX2,NKX6,ZFPM1,NFIL3-4,NEUROG3,HOXA2,NFATC4,ZBTB7A,BACH1,TBX15 |
| NOT protein homodimerization activity | MECOM,KCNA3,DDIT3,MSH6,EXT2,NUDT16L1,MYO9B,MSH3 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | NFYC,ZNF264,RFX5,ZIC1,ESR1,MYOD1,BATF2,PAXBP1,CEBPG,MYOG |
| transcription factor binding | MAPK9,NAAA,MED12L,HAND1,EP300,KCTD1,CEBPG,BRD7,HDAC7,HDAC9 |
Interacting Protein
MLXIPL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MLXIPL here. Most of them are supplied by our site. Hope this information will be useful for your research of MLXIPL.
GRB2;MLX
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References
- Aung, LHH; Yin, RX; et al. Association between the MLX Interacting Protein-Like, BUD13 Homolog and Zinc Finger Protein 259 Gene Polymorphisms and Serum Lipid Levels. SCIENTIFIC REPORTS 4:-(2014).
- Seifi, M; Ghasemi, A; et al. Is C771G Polymorphism of MLX interacting protein-like (MLXIPL) Gene a Novel Genetic Risk Factor for Non-alcoholic Fatty Liver Disease?. CELLULAR AND MOLECULAR BIOLOGY 60:37-42(2014).
