MLXIPL

  • Official Full Name

    MLX interacting protein-like
  • Overview

    This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23.
  • Synonyms

    MLXIPL;MLX interacting protein-like;WBSCR14, Williams Beuren syndrome chromosome region 14;carbohydrate-responsive element-binding protein;bHLHd14;carbohydrate response element binding protein;CHREBP;MIO;MONDOB;WS bHLH;Carbohydrate responsive element binding protein;Class D basic helix-loop-helix protein 14;MLX interacting protein like;Mlx interactor;MLX-interacting protein-like;WBS14_HUMAN;WBSCR 14;WBSCR14;Williams Beuren syndrome chromosome region 14;Williams Beuren syndrome chromosome region 14 protein;Williams-Beuren syndrome chromosomal region 14 protein;WS basic helix loop helix leucine zipper protein;WS basic-helix-loop-helix leucine zipper protein;WS-bHLH;Williams-Beuren syndrome chromosome region 14 protein 1;Williams-Beuren syndrome chromosome region 14 protein 2
Cat.# Product name Source (Host) Species Tag Protein Length Price
MLXIPL-111H Recombinant Human MLXIPL, GST-tagged Wheat Germ Human GST
MLXIPL-2041H Recombinant Human MLX Interacting Protein-Like, GST-tagged E.coli Human GST Full L. 648-741 a.a.
MLXIPL-3773C Recombinant Chicken MLXIPL Mammalian Cells Chicken His

    Involved Pathway

    MLXIPL involved in several pathways and played different roles in them. We selected most pathways MLXIPL participated on our site, such as Insulin resistance,Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with MLXIPL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Non-alcoholic fatty liver disease (NAFLD) NDUFC2,NDUFB4,UQCR11,NDUFA13,NDUFC2-KCTD14,GSK3A,NDUFS7,NR1H3,PRKAB2,INS1
    Insulin resistance RPS6KA3B,PIK3CG,PPP1CB,PDPK1,SLC27A4,G6PCA.1,CREB3L1,PPARA,SLC27A5,GSK3AA

    Protein Function

    MLXIPL has several biochemical functions, for example, contributes_to DNA binding,DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MLXIPL itself. We selected most functions MLXIPL had, and list some proteins which have the same functions with MLXIPL. You can find most of the proteins on our site.

    Function Related Protein
    protein heterodimerization activity SNX1,PBX1,CLCF1,ZHX2,AOC3,HOMER2,MEF2A,IL12B,HIST2H2L,GRIN1
    transcription factor binding ENPP2,IGHMBP2,LCOR,FOXO4,TBP,TAF7,GATA3,TMEM173,NFATC4,TRIM6
    transcription factor activity, sequence-specific DNA binding MESP1,NFIL3-6,BUD31,HOXB7A,E2F4,THRAA,ZFP37,PBX1A,TRP53,ZNF207
    RNA polymerase II core promoter proximal region sequence-specific DNA binding OTX1,AKNA,ZGPAT,SALL1,TBX20,MAX,ZNF718,MYOG,NCOA2,NKX2
    DNA binding POU6F2,H2AFB1,ZBTB37,UBTFL1,ZFP521,TBX5A,HOXC3A,OASL1,GTF2A1,KAT6B
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ZBTB20,TCF21,NFE2L3,FOXO1,TFAP2C,CC2D1A,HMGA2,NFIL3-6,ESRRA,CREBBP
    contributes_to DNA binding GTF3C3,GTF3C4,ARNTL1A,MCM7,CLOCKA,AHR2,GTF3C2,GTF3C5,MRE11A,MAFGB
    NOT protein homodimerization activity MSH6,EXT2,DDIT3,MECOM,NUDT16L1,MSH3,KCNA3,MYO9B

    Interacting Protein

    MLXIPL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MLXIPL here. Most of them are supplied by our site. Hope this information will be useful for your research of MLXIPL.

    GRB2;MLX

    Resources

    References

    • Aung, LHH; Yin, RX; et al. Association between the MLX Interacting Protein-Like, BUD13 Homolog and Zinc Finger Protein 259 Gene Polymorphisms and Serum Lipid Levels. SCIENTIFIC REPORTS 4:-(2014).
    • Seifi, M; Ghasemi, A; et al. Is C771G Polymorphism of MLX interacting protein-like (MLXIPL) Gene a Novel Genetic Risk Factor for Non-alcoholic Fatty Liver Disease?. CELLULAR AND MOLECULAR BIOLOGY 60:37-42(2014).

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