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PLOD3

Official Full Name

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
Overview

The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity.
Synonyms

PLOD3; procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3; procollagen-lysine,2-oxoglutarate 5-dioxygenase 3; LH3; lysyl hydroxlase 3; 2-oxoglutarate 5-dioxygenase 3; Lysine hydroxylase 3; Lysyl hydroxylase 3; PLOD3_HUMAN; Procollagen lysine,2 oxoglutarate 5 dioxygenase 3 precursor; Procollagen-lysine;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PLOD3-1794H	Recombinant Human PLOD3, His-tagged	E.coli	His	C-term-400aa	$319 / 25ug
Human	PLOD3-1379HCL	Recombinant Human PLOD3 cell lysate		N/A		Inquiry
Human	PLOD3-5052H	Recombinant Human PLOD3 protein, His-tagged	HEK293	His	25-738aa	Inquiry
Mouse	PLOD3-12986M	Recombinant Mouse PLOD3 Protein	Mammalian Cell	His		Inquiry
Mouse	PLOD3-6857M-B	Recombinant Mouse PLOD3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	PLOD3-6857M	Recombinant Mouse PLOD3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	PLOD3-4530R	Recombinant Rat PLOD3 Protein	Mammalian Cell	His		Inquiry
Rat	PLOD3-4190R	Recombinant Rat PLOD3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	PLOD3-4190R-B	Recombinant Rat PLOD3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	PLOD3-3882Z	Recombinant Zebrafish PLOD3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
PLOD3 Related Research Area

PLOD3 involved in several pathways and played different roles in them. We selected most pathways PLOD3 participated on our site, such as Lysine degradation, Other types of O-glycan biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLOD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Lysine degradation	EHMT1A;SETD8A;SETD8B;GLT25D1;ALDH7A1;SUV39H1B;SETMAR;WHSC1;SETDB1
Other types of O-glycan biosynthesis	B4GALT1;B3GALT4;B3GALTLB;PLOD3;POFUT1;OGT;B3GALTL;COLGALT2;B3GAT1

PLOD3 has several biochemical functions, for example, L-ascorbic acid binding, iron ion binding, procollagen galactosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLOD3 itself. We selected most functions PLOD3 had, and list some proteins which have the same functions with PLOD3. You can find most of the proteins on our site.

Function	Related Protein
L-ascorbic acid binding	OGFOD1;PLOD3;EGLN2;P4HA3;LEPREL1;OGFOD3;P4HA1B;P4HA1A;LEPREL2
iron ion binding	PHF8;ISCUB;CYP2AD6;P4HA1;LTF;CYP46A1.2;CYP2AD3;CYP4A14;CYP21A2
procollagen galactosyltransferase activity	GLT25D2;FAM125B;PLOD3;GLT25D1;COLGALT2
procollagen glucosyltransferase activity	FAM125B;PLOD3
procollagen-lysine 5-dioxygenase activity	FAM125B;PLOD1;PLOD1A;PLOD2;PLOD3
protein binding	PRAP1;TOMM20;RECQL;NOP56;AMELX;FAH;SH3BP2;PAAF1;PCTP

PLOD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLOD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLOD3.

EHMT2; EFHC2; RAB3IP; RHOXF2; 4505953; TECPR1; CCDC85B; DPPA2; EHMT2; ssdna_dc; MYC; cona_canen; ESR1

ECM Regulators