PLOD3

  • Official Full Name

    procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3

  • Overview

    The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity.
  • Synonyms

    PLOD3; procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3; procollagen-lysine,2-oxoglutarate 5-dioxygenase 3; LH3; lysyl hydroxlase 3; 2-oxoglutarate 5-dioxygenase 3; Lysine hydroxylase 3; Lysyl hydroxylase 3; PLOD3_HUMAN; Procollagen lysine,2 oxoglutarate 5 dioxygenase 3 precursor; Procollagen-lysine;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PLOD3-1794H Recombinant Human PLOD3, His-tagged E.coli His C-term-400aa
Human PLOD3-1379HCL Recombinant Human PLOD3 cell lysate N/A
Human PLOD3-5052H Recombinant Human PLOD3 protein, His-tagged HEK293 His 25-738aa
Mouse PLOD3-12986M Recombinant Mouse PLOD3 Protein Mammalian Cell His
Mouse PLOD3-6857M-B Recombinant Mouse PLOD3 Protein Pre-coupled Magnetic Beads HEK293
Mouse PLOD3-6857M Recombinant Mouse PLOD3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PLOD3-4530R Recombinant Rat PLOD3 Protein Mammalian Cell His
Rat PLOD3-4190R Recombinant Rat PLOD3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PLOD3-4190R-B Recombinant Rat PLOD3 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PLOD3-3882Z Recombinant Zebrafish PLOD3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

PLOD3 involved in several pathways and played different roles in them. We selected most pathways PLOD3 participated on our site, such as Lysine degradation, Other types of O-glycan biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLOD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Lysine degradationSUV39H1B;GLT25D2;ALDH3A2A;SETD8B;BBOX1;CAMKMT;EHMT1;ASH1L;ALDH9A1A.1
Other types of O-glycan biosynthesisFUT7;B4GALT1;POMT1;CHST10;GXYLT1;GXYLT1B;B3GALTL;POGLUT1;B3GAT2

PLOD3 has several biochemical functions, for example, L-ascorbic acid binding, iron ion binding, procollagen galactosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLOD3 itself. We selected most functions PLOD3 had, and list some proteins which have the same functions with PLOD3. You can find most of the proteins on our site.

Function Related Protein
L-ascorbic acid bindingP4HA1A;P4HA1B;TMLHE;PAM;LEPREL1;P3H2;PLOD3;P4HA1;DBH
iron ion bindingCYP11A1;TYW5;CYP46A1.2;CH25HL2;CYP2AA8;PAH;CYP2AA12;CYP2AD6;CYP2K16
procollagen galactosyltransferase activityGLT25D2;COLGALT2;PLOD3;GLT25D1;FAM125B
procollagen glucosyltransferase activityFAM125B;PLOD3
procollagen-lysine 5-dioxygenase activityPLOD1A;FAM125B;PLOD1;PLOD3;PLOD2
protein bindingSIAH1;GBP5;EFNB1;IL15RA;C1orf105;ZNF274;LONP1;FAM64A;MAGEB6

PLOD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLOD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLOD3.

EHMT2; EFHC2; RAB3IP; RHOXF2; 4505953; TECPR1; CCDC85B; DPPA2; EHMT2; ssdna_dc; MYC; cona_canen; ESR1

Research Area

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