RAG1

  • Official Full Name

    recombination activating gene 1
  • Overview

    The sequences encoding antigen receptors are split into multiple germline segments which are then combined by a process called V(D)J recombination during immune cells development. A variable (V) segment is combined with a joining (J) segment, and in some
  • Synonyms

    RAG1;recombination activating gene 1;V(D)J recombination-activating protein 1;MGC43321;recombination activating protein 1;RING finger protein 74;RNF74;V(D)J recombination activating protein 1;RAG-1

Recombinant Proteins

  • Mouse
  • Chicken
  • Rhesus macaque
  • Zebrafish
  • Mammalian Cells
  • HEK293
  • His
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
RAG1-13889M Recombinant Mouse RAG1 Protein Mammalian Cells Mouse His
RAG1-2853C Recombinant Chicken RAG1 Mammalian Cells Chicken His
RAG1-3776R Recombinant Rhesus monkey RAG1 Protein, His-tagged Mammalian Cells Rhesus macaque His
RAG1-8963Z Recombinant Zebrafish RAG1 Mammalian Cells Zebrafish His
RAG1-3593R Recombinant Rhesus Macaque RAG1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
RAG1-3593R-B Recombinant Rhesus Macaque RAG1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
RAG1-7400M Recombinant Mouse RAG1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
RAG1-7400M-B Recombinant Mouse RAG1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    RAG1 involved in several pathways and played different roles in them. We selected most pathways RAG1 participated on our site, such as FoxO signaling pathway,Primary i,nodeficiency, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway Fasl,PTENA,MAPK12B,TGFBR1B,FOXO1A,CCNG2,IGF1RB,PTENB,INS2,MAPK10
    nodeficiency AIRE,CD40,TNFRSF13B,RFXANK,RAG2,BTK,IL2RG,CD19,IL7R,RFXAP
    Primary i UNG,AIRE,CD79A,CD8A,IKBKG,CD3D,LCK,CD3E,DCLRE1C,CD40

    Protein Function

    RAG1 has several biochemical functions, for example, DNA binding,T/G mismatch-specific endonuclease activity,UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAG1 itself. We selected most functions RAG1 had, and list some proteins which have the same functions with RAG1. You can find most of the proteins on our site.

    Function Related Protein
    tubulin-glutamic acid ligase activity MARCH9,UBR1,NEURL3,RNF149,TMEM129,UBE2IA,RNF169,HERC2,DTX1,G2E3
    T/G mismatch-specific endonuclease activity GDPD4,SMG6,REXO4,MEIOB,EXO5,ZRANB3,RNASEKA,RNASEKB,TMPPE,ENDOU2
    tubulin-glycine ligase activity TRIM50,RNF180,NEURL3,MARCH5L,MARCH4,DTX1,RNF149,RNF169,ARIH1L,MARCH6
    endonuclease activity ENDOU2,ANG4,EAR14,ERN2,EAR5,EXOG,EAR4,OGG1,RNASEKB,EME2
    protein binding TAL1,PTPRR,NAMPT,THAP11,HPS4,NDUFA13,SCARB2,RASSF1,HNRNPM,ERG
    catalytic activity PCYT1AA,PPM1BA,NDUFA9A,SLC27A2A,MOGS,HSD17B6,RTCD1,ALPI.2,YDJC,SPTLC2B
    ribosomal S6-glutamic acid ligase activity TRIM50,RNF144AB,SIAH2L,TRIM71,TMEM129,MARCH6,ZNRF2B,MUL1A,UBE2IB,NEURL1B
    ubiquitin-protein transferase activity WDSUB1,RNF141,FEM1A,CNOT4B,CBL,MUL1B,STUB1,MUL1A,RNF152,RC3H2
    protein-glycine ligase activity, initiating MYLIPA,RC3H2,ZNRF3,MGRN1A,SIAH1A,ITCHA,LTN1,ARIH1L,RNF144AA,TTLL3

    Interacting Protein

    RAG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAG1.

    Rag2;VPRBP;KPNA1;Ywhae;CUL4A

    Resources

    References

    • Aird, AL; Nevitt, CD; et al. Adipose-derived stromal vascular fraction cells isolated from old animals exhibit reduced capacity to support the formation of microvascular networks. EXPERIMENTAL GERONTOLOGY 63:18-26(2015).
    • Zhang, Y; Hu, XY; et al. Anti-CD40-induced inflammatory E-cadherin plus dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 34:-(2015).

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