RAG1

  • Official Full Name

    recombination activating gene 1
  • Overview

    The sequences encoding antigen receptors are split into multiple germline segments which are then combined by a process called V(D)J recombination during immune cells development. A variable (V) segment is combined with a joining (J) segment, and in some
  • Synonyms

    RAG1;recombination activating gene 1;V(D)J recombination-activating protein 1;MGC43321;recombination activating protein 1;RING finger protein 74;RNF74;V(D)J recombination activating protein 1;RAG-1

Recombinant Proteins

  • Mouse
  • Chicken
  • Rhesus macaque
  • Zebrafish
  • Mammalian Cells
  • HEK293
  • His
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
RAG1-13889M Recombinant Mouse RAG1 Protein Mammalian Cells Mouse His
RAG1-2853C Recombinant Chicken RAG1 Mammalian Cells Chicken His
RAG1-3776R Recombinant Rhesus monkey RAG1 Protein, His-tagged Mammalian Cells Rhesus macaque His
RAG1-8963Z Recombinant Zebrafish RAG1 Mammalian Cells Zebrafish His
RAG1-3593R Recombinant Rhesus Macaque RAG1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
RAG1-3593R-B Recombinant Rhesus Macaque RAG1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
RAG1-7400M Recombinant Mouse RAG1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
RAG1-7400M-B Recombinant Mouse RAG1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    RAG1 involved in several pathways and played different roles in them. We selected most pathways RAG1 participated on our site, such as FoxO signaling pathway,Primary i,nodeficiency, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway PLK1,GABARAPL2,RAF1B,CCND2,INSRB,RAF1,HOMER2,RBL2,INS1,HRASA
    Primary i CD19,CD8B,RFXAP,UNG,CD79A,RAG2,IL7R,ICOS,DCLRE1C,BLNK
    nodeficiency TNFRSF13B,CD8B,AIRE,ORAI1,CD19,ZAP70,BTK,IL2RG,IKBKG,LCK

    Protein Function

    RAG1 has several biochemical functions, for example, DNA binding,T/G mismatch-specific endonuclease activity,UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAG1 itself. We selected most functions RAG1 had, and list some proteins which have the same functions with RAG1. You can find most of the proteins on our site.

    Function Related Protein
    endonuclease activity ANG4,EAR5,EXOG,DNASE1L3L,EAR4,RNASE6,PPP1R8,RSFR,FEN1,OGG1
    histone binding SIRT1,BAZ2A,CTCFL,NCAPD2,BRD1,HIST1H4C,HIST2H3C,PHF21A,NFKBIL2,PRKCBB
    hydrolase activity, acting on ester bonds APMAP,ACY3.1,C11orf54,ENDOU2,PTER,SMFN,LIPM,ASPA,ACY3.2,ACY3
    retroviral 3 processing activity RNASEKA,REXO1,TMPPE,EXO5,MEIOB,SMG6,GDPD4,ZRANB3,REXO4,ENDOU2
    protein-glycine ligase activity, initiating TRIM71,ARIH1L,RNF144AA,TRIM50,UBE2IA,UBR1,MARCH11,RNF169,NEURL1B,RC3H2
    tubulin-glycine ligase activity RC3H2,SIAH2L,HECW2,SIAH1A,RNF144AB,G2E3,DTX1,MARCH11,UBR1,RFWD2
    protein-glycine ligase activity, elongating MGRN1A,RNF149,HECW2,MYLIPB,SIAH1A,DTX1,MARCH11,G2E3,UBE2IA,MARCH6
    protein-glycine ligase activity MARCH5L,TMEM129,RC3H2,MYLIPB,MARCH4,TRIM71,RNF149,RNF169,HERC2,RNF144AA
    T/G mismatch-specific endonuclease activity EXO5,REXO4,RNASEKB,GDPD4,TMPPE,REXO1,ENDOU2,MEIOB,ZRANB3,SMG6

    Interacting Protein

    RAG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAG1.

    Rag2;VPRBP;KPNA1;Ywhae;CUL4A

    Resources

    References

    • Aird, AL; Nevitt, CD; et al. Adipose-derived stromal vascular fraction cells isolated from old animals exhibit reduced capacity to support the formation of microvascular networks. EXPERIMENTAL GERONTOLOGY 63:18-26(2015).
    • Zhang, Y; Hu, XY; et al. Anti-CD40-induced inflammatory E-cadherin plus dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 34:-(2015).

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