| Official Full Name | recombination activating gene 1 |
| Background | The sequences encoding antigen receptors are split into multiple germline segments which are then combined by a process called V(D)J recombination during immune cells development. A variable (V) segment is combined with a joining (J) segment, and in some |
| Synonyms | RAG1; recombination activating gene 1; V(D)J recombination-activating protein 1; MGC43321; recombination activating protein 1; RING finger protein 74; RNF74; V(D)J recombination activating protein 1; RAG-1 |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
rag1 involved in several pathways and played different roles in them. We selected most pathways rag1 participated on our site, such as FoxO signaling pathway, Primary i, nodeficiency, which may be useful for your reference. Also, other proteins which involved in the same pathway with rag1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FoxO signaling pathway | G6PC3; PIK3R3B; CDKN1BA; FASLG; NLK; INS2; PLK2B; PRMT1; PRKAG3B; IL6 |
| Primary i | BTK; IKBKG; CD3D; TNFRSF13B; RAG1; CD8B1; ORAI1; CD4; RFXAP; Cd79a, Cd79b |
| nodeficiency | CD40LG; AIRE; IL2RG; RFX5; CD4; RFXANK; TNFRSF13B; IGLL1; ICOS; CD3D |
rag1 has several biochemical functions, for example, DNA binding, T/G mismatch-specific endonuclease activity, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by rag1 itself. We selected most functions rag1 had, and list some proteins which have the same functions with rag1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | NR2C1; FOXP1B; TBX5A; MYCL1; ZFP507; HER2; HOXD13; ZNF230; ZNF550; DACH2 |
| T/G mismatch-specific endonuclease activity | REXO1; ENDOU2; MEIOB; RNASEKB; SMG6; REXO4; TMPPE; ZRANB3; EXO5; GDPD4 |
| UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity | TMEM129; TRIM71; RAG1; RNF169; MARCH6; G2E3; RNF144AB; UBE2IA; MARCH4; RNF149 |
| acid-amino acid ligase activity | RAG1; UBA3; TRIM25; RNF41 |
| catalytic activity | PNP4B; PCYT1BB; SYN1; APOBEC2B; GNSA; PLD1A; MDH1AA; GOT2A; ALDOCA; PKMA |
| coenzyme F420-0 gamma-glutamyl ligase activity | SHRPRBCK1R; MARCH5L; UBE2IA; TRIM71; SIAH2L; RC3H2; UBE2IB; ARIH1L; ZNRF2B; RFWD2 |
| coenzyme F420-2 alpha-glutamyl ligase activity | MARCH4; UBE2IA; RNF187; NEURL1B; RNF144AA; LTN1; RFWD2; TRIM50; RNF180; DTX1 |
| endonuclease activity | CENPT; EXOG; ZRANB3; DROSHA; RNASEKA; SMG6; OGG1; PELO; PNKP; CL2 |
| histone binding | LEF1; SUPT6H; CD1d1; PRKCBB; HIST2H3C1; UIMC1; TBL1XR1; NCL; DEK; HIST1H3H |
| hydrolase activity | HE2; USP9; GDPD4; LIPN; DHX34; DOM3Z; PTPRU; CAPN2L; RPE65B; SSH2B |
| hydrolase activity, acting on ester bonds | RAG1; PTER; ACY3; LIPN; ENDOU2; LIPK; C11orf54; PGAP3; LIPM; SMFN |
| ligase activity | UBE2KA; RNF34; TRIM41; LTN1; RNF144AB; TRIM6; GLULA; TRIM37; UBE2KB; UBE2L3B |
| metal ion binding | CYP2AA2; PTGS2; GTF3AA; NADK; ZFP553; ZBTB17; MT4; RPAIN; ZFP13; ADIPOR1 |
| nuclease activity | REXO4; ASTE1; HARBI1; EAR5; EXO5; DNASE1L3L; TDP2; CNOT6L; EAR1; DNA2 |
| nucleic acid binding | ZNRD1; QKI2; SREK1IP1; PPARGC1A; RBM33; TDRD9; DBF4; DPPA5A; AKAP1B; RNASE12 |
| phosphoric ester hydrolase activity | ZRANB3; FBP1A; EXO5; RAG1; REXO4; REXO1; RNASEKA; GDPD4; TMPPE; SACM1L |
| protein binding | LCAT; SR140; TNFRSF14; FAM127B; PRKG1; PIP; CD160; MDM2; ENTPD3; HEATR5B |
| protein homodimerization activity | CARM1; BLOC1S6; DMRT3; RAB11FIP4; PEX11B; PCYT1A; CCBL1; BST2; CADM1; ZFP423 |
| protein-glutamic acid ligase activity | MGRN1A; ITCHA; LTN1; MARCH5L; ARIH1L; TMEM129; RNF187; SIAH2L; UBE2IB; RNF169 |
| protein-glycine ligase activity | MARCH9; RNF169; SIAH2L; MGRN1A; HECW2; UBE2IA; MYLIPB; ITCHA; TRIM50; LTN1 |
| protein-glycine ligase activity, elongating | RNF149; HECW2; ZNRF2B; MYLIPA; MARCH9; RNF187; SIAH2L; RNF169; DTX1; RNF180 |
| protein-glycine ligase activity, initiating | MARCH6; SIAH2L; ITCHA; G2E3; RFWD2; SIAH1A; RNF149; ZNRF3; ZNRF2B; MGRN1A |
| retroviral 3 processing activity | EXO5; TMPPE; RNASEKA; RAG1; GDPD4; ZRANB3; REXO4; REXO1; MEIOB; ENDOU2 |
| ribosomal S6-glutamic acid ligase activity | LTN1; TMEM129; ZNRF2B; TRIM50; UBE2IA; ITCHA; SHRPRBCK1R; MARCH5L; ARIH1L; HECW2 |
| sequence-specific DNA binding | SFPI1; SIX4B; LHX1B; MEOX2B; ZGPAT; RXRAA; POU3F3B; HOXB4; ZKSCAN3; PRRXL1 |
| tubulin-glutamic acid ligase activity | TRIM50; MARCH6; RNF169; RFWD2; UBR1; RC3H2; SIAH1A; ARIH1L; RNF187; RNF149 |
| tubulin-glycine ligase activity | RNF169; SIAH1A; MUL1A; SIAH2L; HERC2; LTN1; DTX1; MYLIPB; RAG1; MARCH11 |
| ubiquitin protein ligase activity | RNF222; NEDD4; UBE2NA; MED31; AMFR; CBLC; MED23; UBE2O; RNF180; UBE2R2 |
| ubiquitin-protein transferase activity | PDZRN3B; MIB2; PRKCQ; MUL1A; FBXO2; FBXL5; FBXL14; MARCH4; MARCH5L; LNX1 |
| zinc ion binding | MYT1LA; ALPP; MYLIPA; UHRF2; ZFAND6; ZKSCAN5; NEURL1B; ADH8B; DTX2; MICALL2 |
rag1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with rag1 here. Most of them are supplied by our site. Hope this information will be useful for your research of rag1.
Rag2; VPRBP; KPNA1; Ywhae; CUL4A
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