RAG1
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Official Full Name
recombination activating gene 1 -
Overview
The sequences encoding antigen receptors are split into multiple germline segments which are then combined by a process called V(D)J recombination during immune cells development. A variable (V) segment is combined with a joining (J) segment, and in some -
Synonyms
RAG1;recombination activating gene 1;V(D)J recombination-activating protein 1;MGC43321;recombination activating protein 1;RING finger protein 74;RNF74;V(D)J recombination activating protein 1;RAG-1
Recombinant Proteins
- Mouse
- Chicken
- Rhesus macaque
- Zebrafish
- Mammalian Cells
- HEK293
- His
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RAG1-13889M | Recombinant Mouse RAG1 Protein | Mammalian Cells | Mouse | His |
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| RAG1-2853C | Recombinant Chicken RAG1 | Mammalian Cells | Chicken | His |
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| RAG1-3776R | Recombinant Rhesus monkey RAG1 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| RAG1-8963Z | Recombinant Zebrafish RAG1 | Mammalian Cells | Zebrafish | His |
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| RAG1-3593R | Recombinant Rhesus Macaque RAG1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
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| RAG1-3593R-B | Recombinant Rhesus Macaque RAG1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| RAG1-7400M | Recombinant Mouse RAG1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| RAG1-7400M-B | Recombinant Mouse RAG1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
RAG1 involved in several pathways and played different roles in them. We selected most pathways RAG1 participated on our site, such as FoxO signaling pathway,Primary i,nodeficiency, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| nodeficiency | IL7R,PTPRC, Cd79b,IL2RG,TAP1,LCK,RFX5,IGLL1,CD8A,TAP2 |
| FoxO signaling pathway | IRS2,FASLG,CDKN1BA,TGFB3,SMAD3A,KLF2,HOMER1,SETD7,SGK2A,TNFSF10 |
| Primary i | AIRE,CD8B1,AICDA,Cd79a,CD3E,CD4,LCK,TNFRSF13B,IL7R,UNG |
Protein Function
RAG1 has several biochemical functions, for example, DNA binding,T/G mismatch-specific endonuclease activity,UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAG1 itself. We selected most functions RAG1 had, and list some proteins which have the same functions with RAG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nuclease activity | EXOG,USB1,DNASE1L3L,RNASEKB,EXO5,EAR2,RNASEKA,TMPPE,SND1,CNOT6 |
| protein-glutamic acid ligase activity | UBE2IA,MARCH6,SIAH2L,MGRN1A,RNF187,ITCHA,SHRPRBCK1R,RNF169,HERC2,NEURL1B |
| ligase activity | TRIM22,UBR5,CBX4,RANBP2,PELI1,SMURF1,SHRPRBCK1R,TRIM5,RNF152,UCHL1 |
| hydrolase activity, acting on ester bonds | PGAP3,SMFN,IAH1,PTER,ACY3.2,LIPM,ESD,ENDOU2,ACY3,C11orf54 |
| nucleic acid binding | GLIS2,ZFPM1,ZBTB42,MATR3L,GPANK1,EIF2C3,INSM1B,ZNF711,SFRS3B,ZFP131 |
| sequence-specific DNA binding | SIX1,GATA4,HOXA9A,CAMTA2,TEFB,RXRGA,NR1H5,FOXQ1B,SIX1B,ESRRA |
| phosphoric ester hydrolase activity | GDPD4,SMG6,TMPPE,SYNJ1,FBP1A,FBP1B,REXO4,INPP5F,SACM1L,RNASEKB |
| tubulin-glutamic acid ligase activity | SIAH1A,TRIM50,ZNRF3,ARIH1L,RNF144AA,UBR1,RFWD2,UBE2IA,MARCH6,MARCH4 |
| metal ion binding | NRP2B,ZNF558,HINFP,ZNF280C,GIT1,LIMCH1B,KLK4,KLF15,PDE11A,BTR12 |
Interacting Protein
RAG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAG1.
Rag2;VPRBP;KPNA1;Ywhae;CUL4A
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References
- Aird, AL; Nevitt, CD; et al. Adipose-derived stromal vascular fraction cells isolated from old animals exhibit reduced capacity to support the formation of microvascular networks. EXPERIMENTAL GERONTOLOGY 63:18-26(2015).
- Zhang, Y; Hu, XY; et al. Anti-CD40-induced inflammatory E-cadherin plus dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 34:-(2015).
