Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

SLC12A1

  • Official Full Name

    solute carrier family 12 (sodium/potassium/chloride transporter), member 1

  • Overview

    This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henles loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010]
  • Synonyms

    SLC12A1; solute carrier family 12 (sodium/potassium/chloride transporter), member 1; BSC1; NKCC2; solute carrier family 12 member 1; NKCC2A variant A; Na-K-2Cl cotransporter; kidney-specific Na-K-Cl symporter; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; solute carrier family 12 (sodium/potassium/chloride transporters), member 1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SLC12A1-1202H Recombinant Human SLC12A1 protein, His & T7-tagged E.coli His/T7 Arg814~Ser1099 (Accession # Q13621)
Human SLC12A1-31410TH Recombinant Human SLC12A1 Wheat Germ N/A 93 amino acids
Human SLC12A1-2697H Recombinant Human SLC12A1, His-tagged E.coli His 1-176aa
Mouse SLC12A1-15207M Recombinant Mouse SLC12A1 Protein Mammalian Cell His
Mouse SLC12A1-8216M Recombinant Mouse SLC12A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SLC12A1-8216M-B Recombinant Mouse SLC12A1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SLC12A1 Related Articles
  • SLC12A1 Related Research Area

SLC12A1 involved in several pathways and played different roles in them. We selected most pathways SLC12A1 participated on our site, such as Cation-coupled Chloride cotransporters, SLC-mediated transmembrane transport, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC12A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cation-coupled Chloride cotransportersSLC12A7;SLC12A1;SLC12A5B;SLC12A3;SLC12A4
SLC-mediated transmembrane transportSLC35A2;SLC35B4;SLC1A4;SLC8A2A;RHCGB;SLC35B2;SLC2A7;SLC7A11;SLC35B3
Transmembrane transport of small moleculesMIPB;RHCGL1;TRPA1B;SLC1A4;FXYD6;SLC38A4;SLC39A6;SLC29A2;SLC6A5
Transport of inorganic cations/anions and amino acids/oligopeptidesSLC36A2;SLC9A9;SLC15A1B;SLC6A6A;SLC6A20A;SLC34A3;SLC7A6;SLC4A2A;SLC6A19B

SLC12A1 has several biochemical functions, for example, potassium ion symporter activity, potassium:chloride symporter activity, sodium ion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC12A1 itself. We selected most functions SLC12A1 had, and list some proteins which have the same functions with SLC12A1. You can find most of the proteins on our site.

Function Related Protein
potassium ion symporter activitySLC12A8;SLC12A7;SLC12A1;SLC12A10.2;SLC12A10.3;SLC12A4;SLC12A10.1;SLC12A5;SLC12A2
potassium:chloride symporter activitySLC12A10.3;SLC12A10.2;SLC12A10.1;SLC12A1;SLC12A8;SLC12A5;SLC12A7;SLC12A4;SLC12A5B
sodium ion transmembrane transporter activitySLC12A1;CNNM4;SLC23A1;SLC12A10.3;TRAPPC10;SLC12A3;ASIC4;SLC12A10.1;SLC12A10.2
sodium:chloride symporter activitySLC12A1;SLC12A10.2;SLC12A10.3;SLC12A3;SLC12A10.1
sodium:potassium:chloride symporter activitySLC12A1;SLC12A10.1;SLC12A10.3;SLC12A10.2

SLC12A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC12A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC12A1.

pta; Oxsr1; Stk39

Rasmussen, LJH; Muller, HSH; et al. Osmotic shrinkage elicits FAK- and Src phosphorylation and Src-dependent NKCC1 activation in NIH3T3 cells. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 308:C101-C110(2015).
Castrop, H; Schiessl, IM; et al. Physiology and pathophysiology of the renal Na-K-2Cl cotransporter (NKCC2). AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 307:F991-F1002(2014).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All SLC12A1 Products

Required fields are marked with *

My Review for All SLC12A1 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends