|Official Full Name||solute carrier family 46 (folate transporter), member 1|
|Background||This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associated with autosomal recessive hereditary folate malabsorption (HFM) disease. HFM is characterized by folate deficiency due to reduced intestinal folate absorption and subsequent anemia, hypoimmunoglobulinemia, and recurrent infections. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.|
|Synonyms||SLC46A1; solute carrier family 46 (folate transporter), member 1; solute carrier family 46, member 1; proton-coupled folate transporter; HCP1; heme carrier protein 1; MGC9564; PCFT; proton coupled folate transporter; G21; PCFT/HCP1; solute carrier family 46 member 1|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
slc46a1 involved in several pathways and played different roles in them. We selected most pathways slc46a1 participated on our site, such as Iron uptake and transport, Metabolism, Metabolism of folate and pterines, which may be useful for your reference. Also, other proteins which involved in the same pathway with slc46a1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Iron uptake and transport||TCIRG1; TFR1B; TFA; FTH1A; SLC46A1; CP; ABCG2D; FLVCR1; ATP6V1G3; MFSD7B|
|Metabolism||TM9SF1; IDO2; SLC25A15B; CTH; PDK2; AQP1A.2; LRPPRC; CYP2R1; ARL2; ARSK|
|Metabolism of folate and pterines||SLC25A32; SLC25A32B; SLC46A1; SLC25A32A|
|Metabolism of vitamins and cofactors||MOCOS; ELA2; SLC25A16; CTRC; NAMPT; CBLC-1; SLC25A32; MMADHC; SLC2A3; LOC100686744|
|Metabolism of water-soluble vitamins and cofactors||MOCOS; SLC46A1; GPHN; SLC5A6B; CYB5A; ELA2L; SLC25A32; CYB5R3; GPHNA; SLC25A32B|
|Mineral absorption||ATP1B1; MT2; SLC30A1; STEAP2; SLC26A6; CYBRD1; MT1H; FXYD2; SLC8A1; HEPH|
|Transmembrane transport of small molecules||SLC35B3; SLC6A5; SLC41A1; FKBP1B; SLC15A1B; SLC6A6A; SLC12A4; CLCA1; SLC26A3.1; TRPM4C|
|Vitamin digestion and absorption||SLC19A3; RBP2; FOLH1; SLC19A1; MMACHC; SLC52A3; SLC23A1; PNLIP; CUBN; SCARB1|
slc46a1 has several biochemical functions, for example, folic acid binding, folic acid transporter activity, NOT heme transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by slc46a1 itself. We selected most functions slc46a1 had, and list some proteins which have the same functions with slc46a1. You can find most of the proteins on our site.
|folic acid binding||SLC19A1; GNMT; FOLR2; SLC46A1; DAAM2; TYMS; DHFR; FTCD; FOLR1; FOLR3|
|folic acid transporter activity||DAAM2; SLC19A1; SLC46A1; FOLR1; SLC25A32; SLC19A2; FOLR2|
|NOT heme transporter activity||SLC46A1|
|hydrogen ion transmembrane transporter activity||ATP6V1AA; SLC46A1; ATP6V0A2B; SLC36A2; ATP5J; ATP5G1; ATP6V0E2; ATP5IB; SLC11A2; ATP5H|
|methotrexate transporter activity||SLC19A1; SLC46A1|
slc46a1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with slc46a1 here. Most of them are supplied by our site. Hope this information will be useful for your research of slc46a1.