• Official Full Name
  • signal peptide peptidase like 2B
  • Background
  • This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • SPPL2B; signal peptide peptidase like 2B; IMP4; PSH4; PSL1; IMP-4; signal peptide peptidase-like 2B; SPP-like 2B; intramembrane protease 4; presenilin-like protein 1; presenilin homologous protein 4;
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SPPL2B Protein
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SPPL2B
Source (Host):Species:Human
Product nameRecombinant Human SPPL2B 293 Cell Lysate