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TAF6L

Official Full Name

TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor
Overview

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that;coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the;polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a;channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily;conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as;coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex;assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase;complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is;composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and;differentiation.
Synonyms

TAF6L; TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor; TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L; TAF6-like RNA polymerase II p300; CBP associated factor associated factor 65 kDa subunit 6L; PAF65 alpha; PAF65A; PCAF associated factor 65 alpha; TAF6 like RNA polymerase II p300/CBP associated factor associated factor 65 kDa subunit 6L;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TAF6L-3106H	Recombinant Human TAF6L, GST-tagged	E.coli	GST	1-351aa	$319 / 25ug
Human	TAF6L-1734HCL	Recombinant Human TAF6L cell lysate		N/A		Inquiry
Human	TAF6L-3364H	Recombinant Human TAF6L protein, His-tagged	E.coli	His	1-351 aa	$319 / 25ug
Zebrafish	TAF6L-7866Z	Recombinant Zebrafish TAF6L	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

TAF6L involved in several pathways and played different roles in them. We selected most pathways TAF6L participated on our site, such as Basal transcription factors, Chromatin modifying enzymes, Chromatin organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAF6L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Basal transcription factors	TBPL2;GTF2H3;GTF2F2B;TAF1;TBP;TAF12;TAF9;GTF2IRD1;GTF2E1
Chromatin modifying enzymes	BRD1;ARID1A;PHF15;PRMT6;DR1;RBBP4;PHF21A;PHF17;ING5B
Chromatin organization	ARID2;BRPF3;KDM3B;TADA2A;SAP30;MTA1;RBB4L;MORF4L2;ANO9A
HATs acetylate histones	ATXN7L3;ELP4;PHF20B;MORF4L1;MEAF6;ING5;ACTL6A;TADA3;ZZZ3
Herpes simplex infection	MHC2A;TNFRSF1A;H2-AA;HNRNPK;IFNB1;BLB1;HCFC1B;TTC6;C3A.2

TAF6L has several biochemical functions, for example, DNA binding, contributes_to histone acetyltransferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAF6L itself. We selected most functions TAF6L had, and list some proteins which have the same functions with TAF6L. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	RAG2;PDCD5;SPHK1;ESR2A;ZFP280D;DMBX1B;HOXB2;ZNF124;KDM2AA
contributes_to histone acetyltransferase activity	TAF10;TAF5L;TADA1;TAF9;SUPT7L;TADA2B;TEX30;TADA3;ELP4
protein binding	BCL2L15;C19orf46;SCG2;PTK2B;SYT16;C1S;FGF2;FOXK2;RBM12B
protein heterodimerization activity	H3F3B;HIST1H2BD;MAFGA;CABYR;HIST1H4K;Pdgfa&Pdgfb;CHRNA5;ALX1;TAF9
transcription coactivator activity	NFATC4;AIP;PPARGC1A;ECD;DYRK1B;CCAR1;TUBB3;ACTL6B;MED31

TAF6L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAF6L here. Most of them are supplied by our site. Hope this information will be useful for your research of TAF6L.

TAF9; TAF9B; USP22; STX11; MYOG; KAT2B; CCDC101

Research Area

Weake, VM; Swanson, SK; et al. A novel histone fold domain-containing protein that replaces TAF6 in Drosophila SAGA is required for SAGA-dependent gene expression. GENES & DEVELOPMENT 23:2818-2823(2009).