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VPS45

Official Full Name

vacuolar protein sorting 45 homolog (S. cerevisiae)
Overview

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators.
Synonyms

VPS45; vacuolar protein sorting 45 homolog (S. cerevisiae); vacuolar protein sorting 45A (yeast homolog) , vacuolar protein sorting 45A (yeast) , VPS45A, VPS45B; vacuolar protein sorting-associated protein 45; h vps45; H1; h-VPS45; H1VPS45; HGNC:14579; hlVps45; Leucocyte vacuolar protein sorting 45; OTTHUMP00000014482; Vacuolar protein sorting 45A (yeast homolog); Vacuolar protein sorting 45A; Vacuolar protein sorting 45B (yeast); VPS45_HUMAN; VPS45A; VPS45B; VPS54A; VSP45; VSP45A;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

HEK293
HEK293T
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	VPS45-384HCL	Recombinant Human VPS45 293 Cell Lysate	HEK293	Non	Inquiry
Mouse	VPS45-18379M	Recombinant Mouse VPS45 Protein	Mammalian Cell	His	Inquiry
Mouse	Vps45-6943M	Recombinant Mouse Vps45 Protein, Myc/DDK-tagged	HEK293T	Myc&DDK	Inquiry
Mouse	VPS45-10071M-B	Recombinant Mouse VPS45 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	VPS45-10071M	Recombinant Mouse VPS45 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi	Inquiry
Rat	VPS45-6544R	Recombinant Rat VPS45 Protein	Mammalian Cell	His	Inquiry
Rat	VPS45-6200R	Recombinant Rat VPS45 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi	Inquiry
Rat	VPS45-6200R-B	Recombinant Rat VPS45 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	VPS45-8184Z	Recombinant Zebrafish VPS45	Mammalian Cell	His	Inquiry
Chicken	VPS45-3233C	Recombinant Chicken VPS45	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein

VPS45 involved in several pathways and played different roles in them. We selected most pathways VPS45 participated on our site, such as Endocytosis, Factors involved in megakaryocyte development and platelet production, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VPS45 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Endocytosis	ARFGEF2;EHD2B;DDL-2;GRK1;RHOAC;WASH;ERBB3B;SPG20;RAB7
Factors involved in megakaryocyte development and platelet production	MFN1;PHF21A;HBG1;KIF2C;MYB;CABLES1;LRRC16A;IRF2A;OSTN
Hemostasis	KIF15;LOC100514666;MGC173646;CD177;ANGPT2A;SIRPA;APOBB.1;F13A1B;KIF4

VPS45 has several biochemical functions, for example, molecular_function, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VPS45 itself. We selected most functions VPS45 had, and list some proteins which have the same functions with VPS45. You can find most of the proteins on our site.

Function	Related Protein
molecular_function	TMEM86A;RTN2A;LSM12B;RCCD1;ARL6IP5;SMIM11;SAP130A;FAM169AA;D4WSU53E
protein binding	PCNP;ZC3H11A;ARR3;CTSC;PAX9;KIAA0368;COPS3;PIAS3;CISD2

VPS45 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VPS45 here. Most of them are supplied by our site. Hope this information will be useful for your research of VPS45.

RBSN; BCAR3; IGF1R; PTPN1; PAX2; CASP8; RB1CC1; gtp; pi3p; ere_dna