• Official Full Name

    WD repeat domain 12

  • Background

    This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.
  • Synonyms

    WDR12; WD repeat domain 12; ribosome biogenesis protein WDR12; FLJ10881; YTM1; WD repeat-containing protein 12; FLJ12719; FLJ12720;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mamanlian cells
    • Mammalian Cell
    • Tag :
    • Flag
    • His
    • His (Fc)
    • Avi
    • Myc
    • DDK
    • Myc|DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human WDR12-114H Recombinant Human WDR12 protein, His-tagged E.coli His
    Human WDR12-355HCL Recombinant Human WDR12 293 Cell Lysate HEK293 N/A
    Human WDR12-7201HFL Recombinant Full Length Human WDR12, Flag-tagged Mamanlian cells Flag
    Human WDR12-49H Recombinant Human WDR12, MYC/DDK-tagged HEK293 Myc/DDK
    Human WDR12-2381H Recombinant Human WDR12 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Wdr12-6973M Recombinant Mouse Wdr12 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat WDR12-6565R Recombinant Rat WDR12 Protein Mammalian Cell His
    Rat WDR12-6221R Recombinant Rat WDR12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat WDR12-6221R-B Recombinant Rat WDR12 Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque WDR12-5193R Recombinant Rhesus monkey WDR12 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque WDR12-5006R-B Recombinant Rhesus Macaque WDR12 Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque WDR12-5006R Recombinant Rhesus Macaque WDR12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Zebrafish WDR12-9960Z Recombinant Zebrafish WDR12 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • WDR12 Related Articles

    WDR12 involved in several pathways and played different roles in them. We selected most pathways WDR12 participated on our site, such as Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WDR12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Delta-Notch Signaling PathwayYY1;TCF3B;CNTFR;MAGEA1;ASCL1A;NOV;SAP30;ZFPM1;YY1A

    WDR12 has several biochemical functions, for example, protein binding, ribonucleoprotein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WDR12 itself. We selected most functions WDR12 had, and list some proteins which have the same functions with WDR12. You can find most of the proteins on our site.

    Function Related Protein
    protein bindingPCTP;DHX32;BCDIN3D;RBMX;C1orf94;MEAF6;NFKBIZ;ALKBH8;DSC2
    ribonucleoprotein complex bindingRNF135;CKAP5;ITCH;TIMM50;PES;PRMT5;IFIH1;SRP54;CD2BP2

    WDR12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WDR12 here. Most of them are supplied by our site. Hope this information will be useful for your research of WDR12.

    BOP1; PES1; MNDA; IFI16

    Xu, WJ; Grain, D; et al. Complexity and robustness of the flavonoid transcriptional regulatory network revealed by comprehensive analyses of MYB-bHLH-WDR complexes and their targets in Arabidopsis seed. NEW PHYTOLOGIST 202:132-144(2014).
    Li, Q; Zhao, PP; et al. Genome-wide analysis of the WD-repeat protein family in cucumber and Arabidopsis. MOLECULAR GENETICS AND GENOMICS 289:103-124(2014).
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