WDR12
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Official Full Name
WD repeat domain 12 -
Overview
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit. -
Synonyms
WDR12;WD repeat domain 12;ribosome biogenesis protein WDR12;FLJ10881;YTM1;WD repeat-containing protein 12;FLJ12719;FLJ12720
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Mouse
- E.coli
- HEK293
- Mammalian Cells
- His
- DDK
- Myc
- Non
- Avi
- Fc
- Flag
Involved Pathway
WDR12 involved in several pathways and played different roles in them. We selected most pathways WDR12 participated on our site, such as Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WDR12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Delta-Notch Signaling Pathway | CNTN1,TUBB3,YY1,NOV,YY1A,JAG1,SMAD3B,ADAM10A,HEY2,HIVEP3 |
Protein Function
WDR12 has several biochemical functions, for example, protein binding,ribonucleoprotein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WDR12 itself. We selected most functions WDR12 had, and list some proteins which have the same functions with WDR12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | GIT2,PCGF6,GZMM,ABHD16A,RCAN1,HOXA1,SVIL,UVRAG,ERGIC2,MTAP1B |
| ribonucleoprotein complex binding | PES1,RNF135,YBX2,PQBP1,UHMK1,PITX2,PIGC,PRMT5,ITCH,TIMM50 |
Interacting Protein
WDR12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WDR12 here. Most of them are supplied by our site. Hope this information will be useful for your research of WDR12.
BOP1;PES1;MNDA;IFI16
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References
- Li, Q; Zhao, PP; et al. Genome-wide analysis of the WD-repeat protein family in cucumber and Arabidopsis. MOLECULAR GENETICS AND GENOMICS 289:103-124(2014).
- Xu, WJ; Grain, D; et al. Complexity and robustness of the flavonoid transcriptional regulatory network revealed by comprehensive analyses of MYB-bHLH-WDR complexes and their targets in Arabidopsis seed. NEW PHYTOLOGIST 202:132-144(2014).
