|Official Full Name||WD repeat domain 19|
|Background||This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains six WD repeats, a clathrin heavy-chain repeat, and three transmembrane domains. This gene is conserved from C. elegans to human. It may participate in androgen-regulated signaling mechanisms or in the vesicular trafficking of androgen-regulated secretory processes. Alternatively spliced transcript variants encoding distinct isoforms have been reported but the full-length nature of one of these variants has not been defined.|
|Synonyms||WDR19; WD repeat domain 19; WD repeat-containing protein 19; DYF 2; FLJ23127; IFT144; intraflagellar transport 144 homolog (Chlamydomonas); KIAA1638; ORF26; Oseg6; Pwdmp; DYF2; Intraflagellar transport 144 homolog; WD repeat containing protein 19; WD repeat membrane protein PWDMP; WDR19_HUMAN; OTTHUMP00000218257; DYF-2|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
wdr19 involved in several pathways and played different roles in them. We selected most pathways wdr19 participated on our site, such as Assembly of the primary cilium, Hedgehog off state, Intraflagellar transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with wdr19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Assembly of the primary cilium||UNC119.1; IFT122; ARF4; TCTEX1D1; PCM1; TRAF3IP1; BBS12; KIFAP3B; CEP72; AKAP9|
|Hedgehog off state||TTC21B; IFT172; OFD1; IFT122; KIF3A; IFT52; BBS13; KIF7; GPR161; RPGRIP1L|
|Intraflagellar transport||TTC30A1; TNPO1; DYNLRB1; IFT46; KIFAP3B; DYNLL2; TTC30A2; IFT81; WDR19; OST4|
|Organelle biogenesis and maintenance||UNC119.1; DAP3; TFB1M; MRPL10; ATAT1; MRPL50; MRPS34; CC2D2A; BBS4; HSPB11|
|Signal Transduction||APOA4B.2; RAMP2; LRIG1; USP9; RDH14A; ARHGAP17; RSPO2; RDH14B; OXER1; CDC42EP3|
|Signaling by Hedgehog||EVC2; EFCAB7; NOTUM; BBS13; IFT122; TULP3; BOC; NOTUM1A; MKS1; IFT52|
wdr19 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by wdr19 itself. We selected most functions wdr19 had, and list some proteins which have the same functions with wdr19. You can find most of the proteins on our site.
wdr19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with wdr19 here. Most of them are supplied by our site. Hope this information will be useful for your research of wdr19.