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WDR19

Official Full Name

WD repeat domain 19
Overview

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains six WD repeats, a clathrin heavy-chain repeat, and three transmembrane domains. This gene is conserved from C. elegans to human. It may participate in androgen-regulated signaling mechanisms or in the vesicular trafficking of androgen-regulated secretory processes. Alternatively spliced transcript variants encoding distinct isoforms have been reported but the full-length nature of one of these variants has not been defined.
Synonyms

WDR19; WD repeat domain 19; WD repeat-containing protein 19; DYF 2; FLJ23127; IFT144; intraflagellar transport 144 homolog (Chlamydomonas); KIAA1638; ORF26; Oseg6; Pwdmp; DYF2; Intraflagellar transport 144 homolog; WD repeat containing protein 19; WD repeat membrane protein PWDMP; WDR19_HUMAN; OTTHUMP00000218257; DYF-2;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque

Source

E.coli
HEK293
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	WDR19-3709H	Recombinant Human WDR19, His-tagged	E.coli	His	1-353aa	$319 / 25μg
Human	WDR19-1925HCL	Recombinant Human WDR19 cell lysate		Non		Inquiry
Mouse	WDR19-18456M	Recombinant Mouse WDR19 Protein	Mammalian Cell	His		Inquiry
Mouse	WDR19-10121M-B	Recombinant Mouse WDR19 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	WDR19-10121M	Recombinant Mouse WDR19 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rhesus Macaque	WDR19-5194R	Recombinant Rhesus monkey WDR19 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	WDR19-5007R	Recombinant Rhesus Macaque WDR19 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rhesus Macaque	WDR19-5007R-B	Recombinant Rhesus Macaque WDR19 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

WDR19 involved in several pathways and played different roles in them. We selected most pathways WDR19 participated on our site, such as Assembly of the primary cilium, Hedgehog off state, Intraflagellar transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with WDR19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Assembly of the primary cilium	CCT3;CEP135;CP110;CEP70;TTC30B;LZTFL1;UNC119.1;CDK5RAP2;TCP1
Hedgehog off state	MKS1;WDR35;KIF3A;IFT172;IFT52;TTC21B;KIF7;RPGRIP1L;INTU
Intraflagellar transport	IFT20;TCTEX1D2;IFT81;WDR19;TTC30B;OST4;WDR35;RABL5;DYNLL2A
Organelle biogenesis and maintenance	IFT20;MRPL53;DYNLL2A;MRPL28;MRPL50;ARF4;TTBK2;MRPL44;PPRC1
Signal Transduction	CGNB;GPR77;TLE3B;OPN4B;ARHGAP17;GDI2;S1PR5B;GPR31;RDH7
Signaling by Hedgehog	IFT122;TTC21B;DISP2;WDR19;DZIP1;GAS8;IFT172;EFCAB7;KIF7

WDR19 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by WDR19 itself. We selected most functions WDR19 had, and list some proteins which have the same functions with WDR19. You can find most of the proteins on our site.

Function	Related Protein

WDR19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WDR19 here. Most of them are supplied by our site. Hope this information will be useful for your research of WDR19.