WDR45 involved in several pathways and played different roles in them. We selected most pathways WDR45 participated on our site, such as Cellular responses to stress, Macroautophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with WDR45 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Cellular responses to stress |
CDKN2A; GABARAPL2; BMI1A; TNIK; C11orf73; HMGA1-RS1; TXN2; RRAGA; DYNLL2; HSBP1A |
| Macroautophagy |
MAP1LC3C; GABARAP; WIPI1; ATG9A; AMBRA1B; RB1CC1; LC3; ULK1A; AMBRA1A; GABARAPL2 |
WDR45 has several biochemical functions, for example, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-3-phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WDR45 itself. We selected most functions WDR45 had, and list some proteins which have the same functions with WDR45. You can find most of the proteins on our site.
| Function |
Related Protein |
| phosphatidylinositol-3,5-bisphosphate binding |
SESTD1; KIF16B; RS1; CLVS2; FAM21C; RAG2; WIPI2; JPH2; WDR45L; GBF1 |
| phosphatidylinositol-3-phosphate binding |
PLEKHF1; SNX27; SNX3; KIF16B; SNX19; WIPI1; SNX13; BBS5; NCF4; ZFYVE19 |
WDR45 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WDR45 here. Most of them are supplied by our site. Hope this information will be useful for your research of WDR45.
MDM2; ATG2A; ATG2B; mgtE; ATG2A; Atg2a
Saitsu, H; Nishimura, T; et al. De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood. NATURE GENETICS 45:445-449(2013).
Guderian, G; Peter, C; et al. RioK1, a New Interactor of Protein Arginine Methyltransferase 5 (PRMT5), Competes with pICln for Binding and Modulates PRMT5 Complex Composition and Substrate Specificity. JOURNAL OF BIOLOGICAL CHEMISTRY 286:1976-1986(2011).
