WDR45
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Official Full Name
WD repeat domain 45 -
Overview
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. -
Synonyms
WDR45;WD repeat domain 45;WD repeat domain, X linked 1 , WDRX1;WD repeat domain phosphoinositide-interacting protein 4;JM5;WIPI4;WD repeat containing protein 45;WD repeat domain phosphoinositide interacting protein 4;WD repeat domain, X linked 1;WD45 repeat protein interacting with phosphoinositides 4;WDRX1;WDRXI4;WIPI 4;WD repeat domain, X-linked 1;WD repeat-containing protein 45;WIPI-4
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Avi
- Fc
Involved Pathway
WDR45 involved in several pathways and played different roles in them. We selected most pathways WDR45 participated on our site, such as Cellular responses to stress,Macroautophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with WDR45 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cellular responses to stress | ULK1A,PRDX2,LAMTOR1,LAMTOR2,HMGA1-RS1,HSPA12B,HSPA14,UBN1,AMBRA1,KIAA1967 |
| Macroautophagy | WDR45L,LC3,MAP1LC3B,ATG7,AMBRA1A,ATG101,GABARAPL2,DYNLL2B,RB1CC1,GABARAP |
Protein Function
WDR45 has several biochemical functions, for example, phosphatidylinositol-3,5-bisphosphate binding,phosphatidylinositol-3-phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WDR45 itself. We selected most functions WDR45 had, and list some proteins which have the same functions with WDR45. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylinositol-3-phosphate binding | SH3PXD2B,RS1,WDR45L,SNX13,BBS5,PLEKHF1,JPH2,LANCL2,D6WSU116E,SNX21 |
| phosphatidylinositol-3,5-bisphosphate binding | SNX3,D6WSU116E,WIPI1,CLVS2,SH3PXD2B,SNX14,SESTD1,WDR45B,FAM21C,KIF16B |
Interacting Protein
WDR45 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WDR45 here. Most of them are supplied by our site. Hope this information will be useful for your research of WDR45.
MDM2;ATG2A;ATG2B;mgtE;ATG2A;Atg2a
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References
- Saitsu, H; Nishimura, T; et al. De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood. NATURE GENETICS 45:445-449(2013).
- Guderian, G; Peter, C; et al. RioK1, a New Interactor of Protein Arginine Methyltransferase 5 (PRMT5), Competes with pICln for Binding and Modulates PRMT5 Complex Composition and Substrate Specificity. JOURNAL OF BIOLOGICAL CHEMISTRY 286:1976-1986(2011).
