Understanding how proteins interact on a residue level is essential during the early stages of drug design and the later stages of lead optimization. It is equally important to identify the locations of any potential allosteric binding sites. This requires researchers to discover the location of protein-ligand binding or protein-protein interaction sites, yet, at the outset of many drug development projects, the location of these sites remains unknown.
As a research-driven biotechnology company, Creative BioMart keeps creating innovative technologies to help researchers screen therapeutic candidates against targets including ion channels, transporters, GPCRs, immuno-oncology targets, and viral envelope proteins. With years of expertise in the expression and characterization of native and recombinant proteins, Creative BioMart has expanded its capabilities to protein binding site mapping. This was achieved using our featured platform, the leading technology for understanding how proteins interact with their companies. Our binding site identification and evaluation services can help researchers locate the binding sites with a high degree of confidence and predict the druggability of those sites.
Creative BioMart’s protein binding site mapping service is not only tailored to cover a wide range of low and high affinity protein-protein interactions, but allows the creation of comprehensive libraries comprising of various structural mimics combined with potentially necessary incorporation of non-canonical residues or PTM mimics. This customized approach helps to precisely map proteins’ interaction sites and reveal the fine details of these interactions.
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