| Description : |
This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Source : |
Wheat germ |
| Species : |
Human |
| Tag : |
GST |
| Molecular Mass : |
75 kDa |
| AA Sequence : |
MDHAEENEILAATQRYYVERPIFSH PVLQERLHTKDKVPDSIADKLKQAF TCTPKKIRNIIYMFLPITKWLPAYK FKEYVLGDLVSGISTGVLQLPQGLA FAMLAAVPPIFGLYSSFYPVIMYCF LGTSRHISIGPFAVISLMIGGVAVR LVPDDIVIPGGVNATNGTEARDALR VKVAMSVTLLSGIIQFCLGVCRFGF VAIYLTEPLVRGFTTAAAVHVFTSM LKYLFGVKTKRYSGIFSVVYSTVAV LQNVKNLNVCSLGVGLMVFGLLLGG KEFNERFKEKLPAPIPLEFFAVVMG TGISAGFNLKESYNVDVVGTLPLGL LPPANPDTSLFHLVYVDAIAIAIVG FSVTISMAKTLANKHGYQVDGNQEL IALGLCNSIGSLFQTFSISCSLSRS LVQEGTGGKTQTIWLTTFVSSLFLG LDYGLITAVIIALLTVIYRTQR |
| Applications : |
ELISA; WB-Re; AP; Array |
| Notes : |
Best use within three months from the date of receipt of this protein. |
| Storage : |
Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer : |
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
