SLC1A2
-
Official Full Name
solute carrier family 1 (glial high affinity glutamate transporter), member 2
-
Overview
This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010] -
Synonyms
SLC1A2; solute carrier family 1 (glial high affinity glutamate transporter), member 2; EAAT2; GLT-1; excitatory amino acid transporter 2; glutamate/aspartate transporter II; excitotoxic amino acid transporter 2; sodium-dependent glutamate/aspartate transporter 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Wheat Germ
- Yeast
- 8His
- MBP,Flag
- GST
- His
- His (Fc)
- Avi
- Flag
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- SLC1A2 Related Research Area
SLC1A2 involved in several pathways and played different roles in them. We selected most pathways SLC1A2 participated on our site, such as Glutamatergic synapse, Amyotrophic lateral sclerosis (ALS), which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC1A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutamatergic synapse | DLGAP1;GNG12;GNAO1;GNB1;PRKCA;PLCB4;GRM2;GNG5;GNAI1 |
| Amyotrophic lateral sclerosis (ALS) | PPP3CB;CYCS;DERL1;TNFRSF1B;PPP3CA;PPP3R1;MAPK14;GRIA1;GRIN2D |
SLC1A2 has several biochemical functions, for example, L-glutamate transmembrane transporter activity, glutamate:sodium symporter activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC1A2 itself. We selected most functions SLC1A2 had, and list some proteins which have the same functions with SLC1A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| L-glutamate transmembrane transporter activity | SLC25A12;SLC1A1;SLC1A2;SLC1A7;SLC25A13;SLC1A6;SLC17A6A;SLC17A6B;SLC25A22 |
| glutamate:sodium symporter activity | SLC1A1;SLC1A2 |
| protein binding | GLYCTK;HBXIP;CBFA2T3;SPAT-1;THY1;TSKS;MED18;H3F3A;BANF1 |
| sodium:dicarboxylate symporter activity | SLC13A5A;SLC13A5;SLC1A2B;SLC1A2A;SLC1A9;SLC1A2;SLC1A7A;SLC1A1;SLC1A7 |
SLC1A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC1A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC1A2.
MAPT; GRB2
- Q&As
- Reviews
Customer Reviews (3)
Write a reviewThe protein's interaction with other APC/C subunits enables the study of its function and the investigation of its involvement in various cellular processes.
The manufacturer of SLC1A2 protein plays a crucial role in supporting my research efforts.
One major advantage of SLC1A2 protein is its ability to contribute to the understanding of diseases related to aberrant cell cycle regulation, including cancer.
Ask a Question for All SLC1A2 Products
Required fields are marked with *
My Review for All SLC1A2 Products
Required fields are marked with *
