SLC27A2

  • Official Full Name

    solute carrier family 27 (fatty acid transporter), member 2

  • Overview

    The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

  • Synonyms

    SLC27A2;solute carrier family 27 (fatty acid transporter), member 2;VLCS;FATP2;VLACS;ACSVL1;FACVL1;hFACVL1;HsT17226;very long-chain acyl-CoA synthetase;FATP-2;THCA-CoA ligase;fatty acid transport protein 2;long-chain-fatty-acid--CoA ligase;solute carrier family 27 member 2;very-long-chain acyl-CoA synthetase;very long-chain-fatty-acid-CoA ligase;very long-chain fatty-acid-coenzyme A ligase 1;fatty-acid-coenzyme A ligase, very long-chain 1

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E.coli
  • Yeast
  • His
  • Non
  • Avi
  • Fc
  • DDK
  • Myc
  • SUMO

    Involved Pathway

    SLC27A2 involved in several pathways and played different roles in them. We selected most pathways SLC27A2 participated on our site, such as Alpha-oxidation of phytanate,Bile acid and bile salt metabolism,Insulin resistance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC27A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Bile acid and bile salt metabolism CYP46A1,CYP8B2,ACOT8,SLC27A2A,AKR1C2,AKR1C21,SCP2B,SLCO1B1,CYP7A1,AKR1C6
    Metabolism of lipids and lipoproteins ALOX5B.3,CPNE1,PNPLA8,CYP4F22,FAAH2,FABP12,CHAT,CPT2,CYP8B2,SLC27A2A
    Metabolism GLTP,ARL2BP,DCT,ACOT11B,SLC5A6B,PEMT,ARV1,AZIN1A,OSBP,AZIN1B
    PPAR signaling pathway PDPK1B,GK,SCP2,PLIN1,RXRA,ACSL1B,Scd2,ACSL4,ME1,SCP2A
    Insulin resistance PDPK1B,PCK2,SLC27A1A,TNFRSF1A,RPS6KA3B,PDPK1,PRKAB1B,SLC2A2,NFKBIA,PPP1R3CB
    Peroxisome BAAT,DHRS4,HMGCLL1,HMGCL,ABCD3A,ACSL5,DDO,PXMP4,CRAT,PEX6
    Alpha-oxidation of phytanate SLC27A2A
    Peroxisomal lipid metabolism CRAT,SCP2B,SLC27A2A

    Protein Function

    SLC27A2 has several biochemical functions, for example, ATP binding,enzyme binding,fatty acid transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC27A2 itself. We selected most functions SLC27A2 had, and list some proteins which have the same functions with SLC27A2. You can find most of the proteins on our site.

    Function Related Protein
    fatty acid transporter activity SLC27A4,SLC27A5,SLC27A1A,SLC27A1B
    enzyme binding UGT1A3,MSH2,STC2,BTG1,EGLN1,TP53,U2AF2,PIAS3,TULP3,NLRP1
    very long-chain fatty acid-CoA ligase activity ACSBG1,SLC27A4,SLC27A1A,SLC27A1B,SLC27A5,SLC27A3,ACSL4
    ATP binding ABCC11,PRKCD,PI4K2A,HELZ,EIF4A2,NEK9,P2RX4A,GART,MAT2AA,ERBB3
    long-chain fatty acid-CoA ligase activity ACSL5,ACSBG2,ACSL3,ACSL4,ACSBG1,SLC27A1B,SLC27A4,SLC27A1A,SLC27A5,ACSL1
    receptor binding CDH5,ADCYAP1,LEPROT,SRMS,RSPO3,CD70,NXPH3,RND1,IDE,TMED1

    Interacting Protein

    SLC27A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC27A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC27A2.

    YWHAZ;purL;Ubr5;ssrna_ug;SLC33A1;CCNB1;CTDSPL2;KPNB1;Tnpo1;SPC24;FAM134A

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