SLC5A2
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Official Full Name
solute carrier family 5 (sodium/glucose cotransporter), member 2
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Overview
This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport;proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in;this gene are associated with renal glucosuria. -
Synonyms
SLC5A2; solute carrier family 5 (sodium/glucose cotransporter), member 2; SGLT2; sodium/glucose cotransporter 2; Low affinity sodium glucose cotransporter; Low affinity sodium-glucose cotransporter; Na(+) glucose cotransporter 2; Na(+)/glucose cotransporter 2; OTTHUMP00000163298; SC5A2_HUMAN; SGLT 2; SLC5A 2; Sodium glucose cotransporter 2; Solute carrier family 5 (sodium glucose cotransporter) member 2; Solute carrier family 5 (sodium/glucose transporter), member 2; Solute carrier family 5 member 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- In vitro E. coli expression system
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- His (Fc)
- Avi
- His|Myc
- SUMO
- Myc
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | SLC5A2-30972TH | Recombinant Human SLC5A2 | Wheat Germ | N/A | 50 amino acids |
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| Human | SLC5A2-1709HCL | Recombinant Human SLC5A2 293 Cell Lysate | HEK293 | N/A |
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| Human | SLC5A2-2396H | Recombinant Human SLC5A2 Transmembrane protein, His-SUMO & Myc-tagged | In vitro E. coli expression system | His-SUMO & Myc | 1-102aa |
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| Human | SLC5A2-2210H | Recombinant Human SLC5A2 Protein (1-102 aa), His-Myc-tagged | E.coli | His/Myc | 1-102 aa |
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| Human | SLC5A2-6306H | Recombinant Human SLC5A2 Protein (Ser335-Leu423), C-His tagged | Mammalian cells | C-His | Ser335-Leu423 |
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| Mouse | SLC5A2-15482M | Recombinant Mouse SLC5A2 Protein | Mammalian Cell | His |
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| Mouse | SLC5A2-8399M | Recombinant Mouse SLC5A2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | SLC5A2-8399M-B | Recombinant Mouse SLC5A2 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | Slc5a2-2078R | Recombinant Rat Slc5a2 Protein, His-tagged | E.coli | N-His | Thr546-Ala648 |
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| Zebrafish | SLC5A2-12179Z | Recombinant Zebrafish SLC5A2 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
SLC5A2 involved in several pathways and played different roles in them. We selected most pathways SLC5A2 participated on our site, such as Hexose transport, Inositol transporters, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC5A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hexose transport | SLC2A3;SLC5A2;SLC5A9;SLC5A4;GCKR |
| Inositol transporters | SLC5A9;SLC2A13;SLC5A11;SLC5A2;SLC5A3A;SLC2A13B;SLC5A4 |
| Metabolism | IVD;DGUOK;NOSTRIN;SLC4A1A;MED18;OSBP;MED20;NAGS;NFYBA |
| Metabolism of carbohydrates | SLC26A1;NHLRC1;SLC35B2;B3GNT2;SLC5A2;UST;B3GNT3;SLC25A11;SLC25A1 |
| Na+-dependent glucose transporters | SLC5A2;SLC5A9;SLC5A4 |
| SLC-mediated transmembrane transport | SLC2A13B;SLC13A4;SLC29A4;SLC7A3;SLCO2A1;SLC1A4;SLC6A1B;RHCGA;SLC35A3 |
| Transmembrane transport of small molecules | ATP1A1A.5;SLC9A3.2;SLC4A4A;ATP1A1A.4;SLC36A2;SLC6A9;SLC6A6;AQP1A.1;SLC43A2A |
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | SLC5A2;SLC30A5;SLC2A7;SLC2A12;SLC5A9;SLC13A5;SLC6A20A;SLC2A10;SLC6A6A |
SLC5A2 has several biochemical functions, for example, low-affinity glucose:sodium symporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC5A2 itself. We selected most functions SLC5A2 had, and list some proteins which have the same functions with SLC5A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| low-affinity glucose:sodium symporter activity |
SLC5A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC5A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC5A2.
- Q&As
- Reviews
Q&As (5)
Ask a questionSLC5A2 inhibitors may have implications beyond diabetes, including potential cardiovascular and renal protective effects.
The SLC5A2 protein plays a crucial role in maintaining normal blood glucose levels by reabsorbing filtered glucose from the urine back into the bloodstream.
Genetic testing for SLC5A2 mutations can help identify individuals with renal glycosuria or other related conditions.
Pharmaceutical companies are developing SGLT2 inhibitors, which can selectively block the activity of the SLC5A2 protein to reduce glucose reabsorption in the kidneys.
In individuals with SLC5A2 mutations, the increased excretion of glucose in the urine may predispose them to urinary tract infections and dehydration.
Customer Reviews (3)
Write a reviewIts stability and compatibility make it an excellent tool for visualizing and characterizing protein structures at high resolution.
The SLC5A2 protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.
the SLC5A2 protein's compatibility with various experimental techniques adds to its versatility.
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