SLC2A1
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Official Full Name
solute carrier family 2 (facilitated glucose transporter), member 1
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Overview
This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. Mutations in this gene have been found in a family with paroxysmal exertion-induced dyskinesia. [provided by RefSeq, Apr 2013] -
Synonyms
SLC2A1; solute carrier family 2 (facilitated glucose transporter), member 1; PED; DYT9; GLUT; DYT17; DYT18; EIG12; GLUT1; HTLVR; GLUT1DS; solute carrier family 2, facilitated glucose transporter member 1; GLUT-1; hepG2 glucose transporter; glucose transporter type 1, erythrocyte/brain; human T-cell leukemia virus (I and II) receptor;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Mamanlian cells
- Mammalian Cell
- Protein Conjugation
- Flag
- His
- Fc
- Avi
- Myc
- SUMO
- DDK
- N
- C
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
SLC2A1 involved in several pathways and played different roles in them. We selected most pathways SLC2A1 participated on our site, such as HIF- signaling pathway, Insulin secretion, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC2A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HIF- signaling pathway | IGF1;PRKCA;TFRC;ARNT;CUL2;BCL2;PGK1;ENO3;Il6ra |
| Insulin secretion | KCNMA1;FXYD2;PRKCB;PRKACG;KCNMB2;ATP1B1;ATP1A4;KCNN3;VAMP2 |
| Thyroid hormone signaling pathway | HIF1A;PLCB3;ACTG1;EP300;PIK3CA;THRB;MED27;STAT1;BAD |
| Adipocytokine signaling pathway | ACSL1A;PPARA;G6PC2;PPARGC1A;ACSL1;PRKAB1;ACSL3A;ACACB;AKT2L |
| Insulin resistance | INS1;PPARAB;GYS1;RPS6KA2;SLC2A1A;PIK3R3;SLC2A2;RPS6KB1B;NFKBIA |
| Bile secretion | SCARB1;ABCB11;ATP1A4;FAM84B;SLC10A2;CA2;SLC22A8;SLC10A1;SLC51B |
| HTLV-I infection | FZD7;POLE3;IL2RB;HLA-DOA;DVL3;EGR1;ATM;FDPS;PPP3R2 |
| Pathways in cancer | FN1;FGFR1;PDGFA;PIK3CB;PLCB4;TRAF6;ARHGEF12;GNG11;PIK3R5 |
| Renal cell carcinoma | TCEB2;PIK3R3;EGLN1;VEGFA;RAP1A;MAPK1;TGFB1;RAC1;PIK3CD |
| Central carbon metabolism in cancer | G6PD;IDH1;SLC7A5;MAPK3;G6PDX;GLS2;SLC16A3;HIF1A;HKDC1 |
SLC2A1 has several biochemical functions, for example, D-glucose transmembrane transporter activity, dehydroascorbic acid transporter activity, glucose transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC2A1 itself. We selected most functions SLC2A1 had, and list some proteins which have the same functions with SLC2A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| D-glucose transmembrane transporter activity | SLC2A1;SLC2A13B;SLC2A2;SLC2A4 |
| dehydroascorbic acid transporter activity | SLC23A1;SLC2A2;SLC2A1 |
| glucose transmembrane transporter activity | SLC2A8;SLC2A5;SLC2A2;SLC2A11L;SLC2A9L1;SLC2A1A;SLC2A11B;SLC2A3;SLC2A3A |
| identical protein binding | FKBP8;DPP9;CLDN3;FBXW7;CAD;GDF5;FRS3;APOE;KCTD17 |
| kinase binding | SRC;PPP2R5A;PRKAA1;CHP1;SGOL1;SP100;CAB39;PFKFB1;TNFAIP3 |
| protein binding | PRKAG1;NGFRB;IFITM1;NEFM;CUTC;RPS7;CDC34;APOA2;CITED1 |
| protein self-association | CCDC88C;PROSAPIP1;L1CAM;AXIN1;VAMP2;TMEM43;EPB49;ZFP639;MALT1 |
| xenobiotic transporter activity |
SLC2A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC2A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC2A1.
VCAM1; COPS6; E2F3; JAK2; STK17B; ATF2; TYK2; Bmpr1a; Cct8
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Q&As (7)
Ask a questionSLC2A1 facilitates the passive transport of glucose across cell membranes, especially in conditions of low glucose concentration.
Besides glucose, SLC2A1 can also transport other hexoses such as galactose.
SLC2A1 expression is upregulated in response to low glucose availability to ensure sufficient glucose uptake.
Therapeutic interventions could involve managing glucose levels and ketogenic diets to bypass the glucose transport defect in conditions like GLUT1 deficiency syndrome.
It is ubiquitously expressed but is particularly prevalent in erythrocytes and the endothelial cells of the blood-brain barrier.
Mutations or dysregulations in SLC2A1 can lead to glucose transport deficiencies, affecting energy supply to cells.
Mutations in SLC2A1 are associated with GLUT1 deficiency syndrome, which can result in epilepsy, developmental delay, and movement disorders.
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