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SLC11A1

  • Official Full Name

    solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1

  • Overview

    This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.
  • Synonyms

    SLC11A1; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1; LSH, NRAMP, NRAMP1; natural resistance-associated macrophage protein 1; natural resistance associated macrophage protein 1; LSH; NRAMP 1; NRAMP; PBC; Solute carrier family 11 (proton coupled divalent metal ion transporters) member 1; solute carrier family 11 (sodium/phosphate symporters) member 1; Solute carrier family 11 member 1; OTTHUMP00000109205; solute carrier family 11 (sodium/phosphate symporters), member 1; NRAMP1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Pig
  • Rat
  • E.coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • 8His
  • MBP,Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SLC11A1-1264H Recombinant Human SLC11A1 protein, GST-tagged Wheat Germ GST
Human SLC11A1-1614HCL Recombinant Human SLC11A1 cell lysate N/A
Human SLC11A1-0391H Recombinant Human SLC11A1 Protein (T2-G550), 8×His-MBP, Flag tagged Insect Cell 8His-MBP,Flag T2-G550
Mouse SLC11A1-15205M Recombinant Mouse SLC11A1 Protein Mammalian Cell His
Mouse SLC11A1-8214M Recombinant Mouse SLC11A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SLC11A1-8214M-B Recombinant Mouse SLC11A1 Protein Pre-coupled Magnetic Beads HEK293
Rat SLC11A1-5424R Recombinant Rat SLC11A1 Protein Mammalian Cell His
Rat SLC11A1-5083R Recombinant Rat SLC11A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SLC11A1-5083R-B Recombinant Rat SLC11A1 Protein Pre-coupled Magnetic Beads HEK293
Pig SLC11A1-5455P Recombinant Pig SLC11A1 Protein (Full Length), N-His tagged E.coli N-His Full Length
Chicken SLC11A1-6523C Recombinant Chicken SLC11A1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SLC11A1 Related Articles

SLC11A1 involved in several pathways and played different roles in them. We selected most pathways SLC11A1 participated on our site, such as Lysosome, Mineral absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC11A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
LysosomeAP3M1;ARSG;GNPTG;ATP6AP1B;ACP2;GALCA;AP1M3;HEXA;AP1M1
Mineral absorptionHMOX2;ATP1B3;CYBRD1;ATP7A;FTL;SLC9A3;HEPH;SLC46A1;SLC26A9

SLC11A1 has several biochemical functions, for example, manganese ion transmembrane transporter activity, metal ion:proton antiporter activity, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC11A1 itself. We selected most functions SLC11A1 had, and list some proteins which have the same functions with SLC11A1. You can find most of the proteins on our site.

Function Related Protein
manganese ion transmembrane transporter activityZP3;SLC11A2;TRPM2;MMGT2;SLC11A1
metal ion:proton antiporter activity
protein homodimerization activityTERF1;ODZ4;TCF3A;ASGR1;ERBB4;MGST1;TLR13;UPK1A;SLC9A7
transition metal ion transmembrane transporter activitySLC11A1;SLC11A2

SLC11A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC11A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC11A1.

Iacoboni, PA; Hasenauer, FC; et al. Polymorphisms at the 3' untranslated region of SLC11A1 gene are associated with protection to Brucella infection in goats. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 160:230-234(2014).
Masala, S; Cossu, D; et al. Recognition of zinc transporter 8 and MAP3865c homologous epitopes by new-onset type 1 diabetes children from continental Italy. ACTA DIABETOLOGICA 51:577-585(2014).
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