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Official Full Name solute carrier family 7 (amino acid transporter light chain, L system), member 8
Background Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.
Synonyms SLC7A8; solute carrier family 7 (amino acid transporter light chain, L system), member 8; LAT2; LPI-PC1; large neutral amino acids transporter small subunit 2; integral membrane protein E16H; L-type amino acid transporter 2; solute carrier family 7 (amino acid transporter, L-type), member 8; solute carrier family 7 (cationic amino acid transporter, y+ system), member 8;
    • Species :
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • Mammalian Cell
    • Tag :
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse SLC7A8-15523M Recombinant Mouse SLC7A8 Protein Mammalian Cell His
    Rat SLC7A8-5579R Recombinant Rat SLC7A8 Protein Mammalian Cell His
    Rhesus Macaque SLC7A8-4314R Recombinant Rhesus monkey SLC7A8 Protein, His-tagged Mammalian Cell His

    slc7a8 involved in several pathways and played different roles in them. We selected most pathways slc7a8 participated on our site, such as Protein digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with slc7a8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Protein digestion and absorption ATP1A3; COL27A1; ATP1B3; KCNQ1; CELA2A; LOC780933; COL6A6; SLC9A3; CTRL; SLC16A10

    slc7a8 has several biochemical functions, for example, L-amino acid transmembrane transporter activity, amine transmembrane transporter activity, amino acid transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by slc7a8 itself. We selected most functions slc7a8 had, and list some proteins which have the same functions with slc7a8. You can find most of the proteins on our site.

    Function Related Protein
    L-amino acid transmembrane transporter activity SLC7A7; SLC7A8; SLC43A1A; SLC43A1B; SLC7A13; SLC7A6; SLC38A7; Nat3; SLC43A2B; SLC43A2A
    amine transmembrane transporter activity SLC22A16; AQP9; SLC7A8
    amino acid transmembrane transporter activity SLC38A11; SLC6A17; SLC3A1; SLC38A2; SLC38A4; SLC7A13; SLC7A2; SLC7A14; SLC7A8; SLC38A10
    antiporter activity SLC25A16; CLCN6; SLC9A9; SLC7A14; SLC35E4; SLC7A3A; CLCN4; SLC35C2; SLC9A6B; SLC35E1
    neutral amino acid transmembrane transporter activity SLC6A19B; SLC7A8; SLC1A5; SLC43A2A; SLC43A1B; SLC43A1A; SLC3A2; SLC43A2B; SLC7A10; SLC38A5
    organic cation transmembrane transporter activity SLC22A2; SLC7A8; SLC22A14; SLC22A1; SLC22A3
    toxin transporter activity LRP6; SLC17A3; ABCG1; SLC22A2; SLC22A3; SLC7A8

    slc7a8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with slc7a8 here. Most of them are supplied by our site. Hope this information will be useful for your research of slc7a8.

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