SLC26A3

  • Official Full Name

    solute carrier family 26, member 3

  • Overview

    The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea.

  • Synonyms

    SLC26A3;solute carrier family 26, member 3;CLD, congenital chloride diarrhea , DRA;chloride anion exchanger;down-regulated in adenoma protein;CLD;DRA

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • Rat
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • GST
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
SLC26A3-2733H Recombinant Human SLC26A3, GST-tagged E.coli Human GST C-term-268aaaa
SLC26A3-15341M Recombinant Mouse SLC26A3 Protein Mammalian Cells Mouse His
SLC26A3-31415TH Recombinant Human SLC26A3 Wheat Germ Human Non 98 amino acids
SLC26A3-4310C Recombinant Chicken SLC26A3 Mammalian Cells Chicken His
SLC26A3-5484R Recombinant Rat SLC26A3 Protein Mammalian Cells Rat His
SLC26A3-1753HCL Recombinant Human SLC26A3 293 Cell Lysate HEK293 Human Non
SLC26A3-5143R Recombinant Rat SLC26A3 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
SLC26A3-5143R-B Recombinant Rat SLC26A3 Protein Pre-coupled Magnetic Beads HEK293 Rat
SLC26A3-8300M Recombinant Mouse SLC26A3 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
SLC26A3-8300M-B Recombinant Mouse SLC26A3 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    SLC26A3 involved in several pathways and played different roles in them. We selected most pathways SLC26A3 participated on our site, such as Mineral absorption,Multifunctional anion exchangers,Pancreatic secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC26A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pancreatic secretion ATP1A4,CLCA1,PRSS1,PLCB3,ATP2A1,PLA2G3,RYR2,LOC780933,ATP2A3,PLA2G10
    Transmembrane transport of small molecules FLVCR1,DMTN,SLC20A1A,CP,TRDN,CLCN6,ANO9,NHEDC1,SLC5A3A,ATP1A1A.2
    Transport of inorganic cations/anions and amino acids/oligopeptides SLC4A2B,SLC4A4A,SLC20A2,SLC7A11,SLC12A3,SLC9A3.2,SLC15A3,SLC6A19B,SLC20A1A,SLC6A6A
    Mineral absorption ATP1A2,SLC26A6,SLC11A1,ATP1B3,SLC46A1,MT1F,SLC30A1,FTL,MT1A,MT1X
    Multifunctional anion exchangers SLC26A6L,SLC26A3.2,SLC26A7,SLC26A1,SLC26A2,SLC26A3.1
    SLC-mediated transmembrane transport SLC15A4,SLC6A7,SLC9A7,SLC30A1A,CP,SLC39A10,SLC1A4,SLC35B3,SLC5A4,SLC28A2

    Protein Function

    SLC26A3 has several biochemical functions, for example, anion:anion antiporter activity,bicarbonate transmembrane transporter activity,chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC26A3 itself. We selected most functions SLC26A3 had, and list some proteins which have the same functions with SLC26A3. You can find most of the proteins on our site.

    Function Related Protein
    chloride transmembrane transporter activity Slc4a2,CFTR,SLC26A6,SLC26A1,SLC26A4,SLC4A1
    transcription cofactor activity IRF3,AIRE,HES6,ZFP710,ZFP667,PRKCBP1L,NFE2L1,ZNF865,PTPN14,NSD1
    bicarbonate transmembrane transporter activity SLC26A1,SLC26A9,SLC26A6,SLC26A2,SLC4A11,SLC26A4,SLC26A5,SLC4A1,SLC26A3.2,CFTR
    transcription factor activity, sequence-specific DNA binding NKX3,NR2C2,TGIF1,BHLHE40,HOXC4A,RNF4,SIM2,CDX2,KDM5A,NANOG
    protein binding PLIN5,KSR1,HMGCR,SIX4,C6orf211,PELI2,ALKBH6,GRM1,NOA1,GOLGA7
    oxalate transmembrane transporter activity SLC26A6,SLC26A11,SLC26A6L,SLC26A5,SLC26A4,SLC26A3.2,SLC26A2,SLC26A3.1,SLC26A7,SLC26A9
    sulfate transmembrane transporter activity SLC26A6,SLC26A1,SLC26A11,SLC26A3.1,SLC26A4,SLC26A9,SLC26A7,SLC26A3.2,SLC26A2,SLC26A6L
    anion:anion antiporter activity SLC26A2,SLC22A9,SLC26A6L,SLC26A7,SLC26A11,SLC4A11,SLC4A8,SLC4A2A,SLC4A2B,SLC26A6
    chloride channel activity CLCN5,SLC26A3.2,CFTR,GABRA6,SLC26A4,SLC26A6,GABRA5,TTYH2,SLC26A5,CLICA

    Interacting Protein

    SLC26A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC26A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC26A3.

    SLC9A3R2

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