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SLC13A3

  • Official Full Name

    solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3

  • Overview

    Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.
  • Synonyms

    SLC13A3; solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3; solute carrier family 13 member 3; NADC3; SDCT2; +dicarboxylate cotransporter 3; H sapiens mRNA for hepatocyte nuclear factor 4 gamma; hNaDC3; Na; Na(+)/dicarboxylate cotransporter 3; NaDC 3; NaDC-3; S13A3_HUMAN; SDCT 2; Sodium dependent high affinity dicarboxylate transporter 2; Sodium-dependent high-affinity dicarboxylate transporter 2; OTTHUMP00000031667; OTTHUMP00000214796; OTTHUMP00000214797; OTTHUMP00000214798; sodium-dependent high affinity dicarboxylate transporter 3; sodium-dependent high-affinity dicar;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Human
  • Zebrafish
  • E.coli
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SLC13A3-1615HCL Recombinant Human SLC13A3 cell lysate N/A
Human SLC13A3-672H Recombinant Human SLC13A3 Protein, GST-tagged Wheat Germ GST 1-602 aa
Human SLC13A3-301259H Recombinant Human SLC13A3 protein, GST-tagged E.coli GST Ser161-Asn229
Human SLC13A3-301399H Recombinant Human SLC13A3 protein, GST-tagged E.coli GST Gln568-Leu602
Human SLC13A3-6818HF Recombinant Full Length Human SLC13A3 Protein, GST-tagged In Vitro Cell Free System GST 602 amino acids
Zebrafish SLC13A3-12157Z Recombinant Zebrafish SLC13A3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SLC13A3 Related Research Area

SLC13A3 involved in several pathways and played different roles in them. We selected most pathways SLC13A3 participated on our site, such as SLC-mediated transmembrane transport, Sodium-coupled sulphate, di- and tri-carboxylate transporters, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC13A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
SLC-mediated transmembrane transportSLC20A1;PDZD11;SLC26A1;SLC22A15;SLC35B2;SLC9A5;SLC6A11;LCN1;SLC9A9
Sodium-coupled sulphate, di- and tri-carboxylate transportersSLC13A2;SLC13A5;SLC13A5A;SLC13A3;SLC13A4;SLC13A1
Transmembrane transport of small moleculesSLC38A4;SLC4A1A;MRS2;SLC30A8;SLC39A2;HTR3C;RHCGA;ANO5B;SLC9A3.2
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsSLC13A4;RHCG2A;SLC6A9;SLC44A5B;SLC2A15A;SLC13A5A;SLC2A8;SLC16A7;RHCG

SLC13A3 has several biochemical functions, for example, L-aspartate transmembrane transporter activity, citrate transmembrane transporter activity, high-affinity sodium:dicarboxylate symporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC13A3 itself. We selected most functions SLC13A3 had, and list some proteins which have the same functions with SLC13A3. You can find most of the proteins on our site.

Function Related Protein
L-aspartate transmembrane transporter activitySLC25A12;SLC1A6;SLC38A7;SLC25A13;SLC13A3
citrate transmembrane transporter activitySLC25A1;SLC13A3;SFXN5;SLC13A5A;SLC13A5
high-affinity sodium:dicarboxylate symporter activity
sodium:dicarboxylate symporter activitySLC13A5A;SLC1A3;SLC1A9;SLC1A8B;SLC1A1;SLC1A5;SLC1A2A;SLC1A2;SLC1A2B
succinate transmembrane transporter activitySLC13A5;SLC13A5A;SLC13A3

SLC13A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC13A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC13A3.

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