SLC9A1

  • Official Full Name

    solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1

  • Overview

    SLC9A1 (NHE1), a member of the Na+/H+ exchanger family, is a ubiquitous membrane protein that regulates intracellular pH and cell volume. Furthermore, SLC9A1 is known to interact with the actin cytoskeleton. Fibroblasts expressing mutated NHE1 that fails

  • Synonyms

    SLC9A1;solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1;APNH, NHE1, solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive) , solute carrier family 9 (sodium/hydrogen ex
Cat.# Product name Source (Host) Species Tag Protein Length Price
SLC9A1-3435C Recombinant Chicken SLC9A1 Mammalian Cells Chicken His
SLC9A1-5584R Recombinant Rat SLC9A1 Protein Mammalian Cells Rat His
SLC9A1-6293Z Recombinant Zebrafish SLC9A1 Mammalian Cells Zebrafish His
SLC9A1-1695HCL Recombinant Human SLC9A1 293 Cell Lysate HEK293 Human Non
SLC9A1-5243R Recombinant Rat SLC9A1 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
SLC9A1-5243R-B Recombinant Rat SLC9A1 Protein Pre-coupled Magnetic Beads HEK293 Rat

    Involved Pathway

    SLC9A1 involved in several pathways and played different roles in them. We selected most pathways SLC9A1 participated on our site, such as cAMP signaling pathway,Cardiac muscle contraction,Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC9A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Regulation of Actin Cytoskeleton FN1,CDC42,ITGA2B,FGF12A,ITGB3B,ITGB2L,MYL9B,FGF11,PIP4K2C,FGF7
    Cardiac muscle contraction TNNC1B,TPM4B,TNNC1,TNNT2,CACNA1C,ATP2A2,TNNC1A,UQCRC1,ACTC1,CACNG2A
    Gastric acid secretion HRH2,CAMK2D,ATP1B2,CA2,KCNK2,PLCB2,ATP1B1,PRKCG,PRKACA,ATP1A4
    Pancreatic secretion FXYD2,PLA2G1B,ATP2A1,PLA2G2E,RAB27B,BST1,RAB8A,ITPR3,KCNQ1,SCTR
    cAMP signaling pathway CALML5,PIK3CG,HTR1F,MAP2K2,PRKACA,HTR4,RELA,AKT2,RRAS2,CALM4
    Adrenergic signaling in cardiomyocytes PIK3CB,FXYD2,RAPGEF3,CAMK2G1,ATP1A2A,CACNA2D4,ATP1A3A,ADRB2A,ATP1A4,CACNG4
    Thyroid hormone signaling pathway HDAC3,NCOA3,MED12L,ATP1A4,NRAS,GSK3B,ATP1B4,FOXO1,MAPK3,MTOR
    Proteoglycans in cancer MAPK13,ESR1,MAP2K2,MDM2,RRAS2,RPS6KB2,WNT10B,PRKCB,FZD1,FN1
    Bile secretion AQP9,SLC2A1,ADCY3,SLCO1A6,SLC4A4,ABCC2,ATP1A4,SCTR,PRKACB,ADCY8

    Protein Function

    SLC9A1 has several biochemical functions, for example, calcium-dependent protein binding,calmodulin binding,phosphatidylinositol-4,5-bisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC9A1 itself. We selected most functions SLC9A1 had, and list some proteins which have the same functions with SLC9A1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding MATR3,COMMD6,RPL7,WBP2,CCL5,LRRIQ3,CLDN16,RPRD1B,CHMP4B,AKTIP
    sodium:proton antiporter activity SLC9A6A,SLC9A7,SLC9A3,SLC9A3.2,SLC9A6B,SLC9A9,SLC9A3.1,SLC9A8,SLC9A4,SLC9A5
    protein complex scaffold ISCU,MAP2K2,SLC9A3R2,MPP7,CAV3,MAGI3,TELO2,DISC1,C9orf142,KLHL17
    solute:proton antiporter activity SLC9A9,NHEDC1,SLC9B2,SLC9A6A,SLC9A4,SLC9A3.1,SLC9A3.2,SLC9A6B,SLC9A10,SLC9A5
    protein binding, bridging LOR,FSCN1,NMD3,FSCN3,NUFIP1,CBX5,ANK2,AMFR,GATAD2A,TIRAP
    phosphatidylinositol-4,5-bisphosphate binding FCHO2,FAM123B,ANXA2,CHMP3,SYTL2,SNX21,MARK1,KCNQ1,SYT1,LDLRAP1
    protein phosphatase 2B binding AKAP1,ATP2B4,PPP3CB,SOD1,BAD,AKAP5,MYOZ2
    calcium-dependent protein binding SYT8,TNNT3,CALM3,C9orf9,DDX5,NRXN1,ANXA2,ANXA3,TSG101,ANXA11
    calmodulin binding GEM,NRGN,PATE4,SPHK1,CAMK1D,KCNQ1,CNGA2,SNTA1,PDE1C,CNN1A

    Interacting Protein

    SLC9A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC9A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC9A1.

    YWHAB;MAP3K7;CHP2;MAP4K4;UBE2I;MDFI;Rab5c;YWHAZ;Gbf1;Taf15;AP4S1;Mad2l1

    Resources

    Research Area

    Reperfusion Injury Therapeutic Targets

    References

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