SLC25A13

  • Official Full Name

    solute carrier family 25, member 13 (citrin)

  • Overview

    This gene is a member of the mitochondrial carrier family. The encoded protein contains four EF-hand Ca(2+) binding motifs in the N-terminal domain, and localizes to mitochondria. The protein catalyzes the exchange of aspartate for glutamate and a proton across the inner mitochondrial membrane, and is stimulated by calcium on the external side of the inner mitochondrial membrane. Mutations in this gene result in citrullinemia, type II. Multiple transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    SLC25A13;solute carrier family 25, member 13 (citrin);CTLN2;calcium-binding mitochondrial carrier protein Aralar2;ARALAR2;CITRIN;mitochondrial aspartate glutamate carrier 2;AI785475;Calcium binding mitochondrial carrier protein Aralar2;Ctrn;RGD1565889;Solute carrier family 25 (citrin) member 13;Solute carrier family 25 member 13 (citrin);Solute carrier family 25 member 13;OTTHUMP00000024692

Recombinant Proteins

  • Chicken
  • Human
  • Cynomolgus
  • Macaca fascicularis
  • Mus musculus
  • Mammalian Cells
  • E.coli
  • Insect Cells
  • HEK293
  • His
  • Non
  • Flag
  • MBP
  • Avi
  • Fc

    Involved Pathway

    SLC25A13 involved in several pathways and played different roles in them. We selected most pathways SLC25A13 participated on our site, such as Gluconeogenesis,Glucose metabolism,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC25A13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Mitochondrial protein import COX17,TIMM8A,MTX2,GRPEL1,TIMM17B,DNAJC19,TIMM50,BCS1L,TOMM6,TIMM9
    Metabolism PDK3,SULT2ST1,COX7C,FAM213B,ABHD14B,CHAT,SLC25A27,OAZ2B,CD320,GLYATL2
    Glucose metabolism AGL,NHLRC1,SLC25A1,EPM2A,GYG1A,PYGMB,PFKLB,SLC25A12,GYG1,GYG2
    Gluconeogenesis GPR19,SLC25A1,SLC25A11,SLC25A12,SLC25A1A,SLC25A10
    Metabolism of carbohydrates PFKLB,UST,OXSR1,SLC26A1,ST3GAL3A,PYGMB,CHP,DSEL,SLC25A12,HS3ST4
    Metabolism of proteins HDGF,TBCA,TRAPPC1,TBCE,EXOSC8,ADAMTS8,FURINB,DPAGT1,B3GALTL,SEC22A

    Protein Function

    SLC25A13 has several biochemical functions, for example, L-aspartate transmembrane transporter activity,L-glutamate transmembrane transporter activity,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC25A13 itself. We selected most functions SLC25A13 had, and list some proteins which have the same functions with SLC25A13. You can find most of the proteins on our site.

    Function Related Protein
    L-aspartate transmembrane transporter activity SLC13A3,SLC38A7,SLC25A12,SLC1A6
    calcium ion binding TBC1D9B,PCDHA5,CABP1,CABP5A,RASGRP2,CALM2,ADAM8,MYL5,SYT9B,BMP1B
    L-glutamate transmembrane transporter activity SLC17A8,SLC38A7,SLC17A6A,SLC25A12,SLC1A3,SLC25A22,SLC1A6,SLC17A6,SLC17A6B,SLC1A7
    transporter activity FXYD2,KIF20A,RLBP1B,SLC12A10.1,SLC4A1B,SLC22A1,ATP5O,RBP2A,SYPL2B,STEAP2

    Interacting Protein

    SLC25A13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC25A13 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC25A13.

    USP50;BABAM1;BRE;15-deoxy-delta(12,14;NDUFA4;IKBKB;XRCC3;SCO1;MT-CO2;MT-CO3;MYC;ALB;Tuba3a;COX6C;ARAF;COX4I1;RNH1;COX7A2;COX6B1;ATF2

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